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UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
SCHEDULE 13G
UNDER THE SECURITIES EXCHANGE ACT OF 1934
(AMENDMENT NO. 1)*
ALNYLAM PHARMACEUTICALS, INC.
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(Name of Issuer)
Common Stock
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(Title of Class of Securities)
02043Q107
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(CUSIP Number)
December 31, 2004
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(Date of Event Which Requires Filing of this Statement)
Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:
[ ] Rule 13d-1(b)
[X] Rule 13d-1(c)
[ ] Rule 13d-1(d)
*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.
The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).
Page 1 of 18 Pages
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CUSIP NO. 02043Q107 13G PAGE 2 OF 18 PAGES
------------------- ------------------
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1 NAMES OF REPORTING PERSONS
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
ARCH Venture Fund V, L.P.
-------------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
(a) [ ]
(b) [ ]
-------------------------------------------------------------------------------
3 SEC USE ONLY
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4 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
-------------------------------------------------------------------------------
5 SOLE VOTING POWER
0
NUMBER OF ------------------------------------------------------------
SHARES 6 SHARED VOTING POWER
BENEFICIALLY
OWNED BY 1,956,527
EACH ------------------------------------------------------------
REPORTING 7 SOLE DISPOSITIVE POWER
PERSON
WITH 0
------------------------------------------------------------
8 SHARED DISPOSITIVE POWER
1,956,527
-------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
1,956,527
-------------------------------------------------------------------------------
10 CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
(SEE INSTRUCTIONS) [ ]
-------------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
9.41%
-------------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
PN
-------------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT!
Page 2 of 18 Pages
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CUSIP NO. 02043Q107 13G PAGE 3 OF 18 PAGES
------------------- ------------------
-----------------------------------------------------------------------------
1 NAMES OF REPORTING PERSONS
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
ARCH V Entrepreneurs Fund, L.P.
-----------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
(a) [ ]
(b) [ ]
-----------------------------------------------------------------------------
3 SEC USE ONLY
-----------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
-----------------------------------------------------------------------------
5 SOLE VOTING POWER
0
NUMBER OF ------------------------------------------------------------
SHARES 6 SHARED VOTING POWER
BENEFICIALLY
OWNED BY 1,956,527
EACH
REPORTING ------------------------------------------------------------
PERSON 7 SOLE DISPOSITIVE POWER
WITH
0
------------------------------------------------------------
8 SHARED DISPOSITIVE POWER
1,956,527
-----------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
1,956,527
-----------------------------------------------------------------------------
10 CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
(SEE INSTRUCTIONS) [ ]
-----------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
9.41%
-----------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
PN
-----------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT
Page 3 of 18 Pages
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CUSIP NO. 02043Q107 13G PAGE 4 OF 18 PAGES
------------------- ------------------
-----------------------------------------------------------------------------
1 NAMES OF REPORTING PERSONS
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
ARCH Venture Partners V, L.P.
-----------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
(a) [ ]
(b) [ ]
-----------------------------------------------------------------------------
3 SEC USE ONLY
-----------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
-----------------------------------------------------------------------------
5 SOLE VOTING POWER
0
NUMBER OF ------------------------------------------------------------
SHARES 6 SHARED VOTING POWER
BENEFICIALLY
OWNED BY 1,956,527
EACH
REPORTING ------------------------------------------------------------
PERSON 7 SOLE DISPOSITIVE POWER
WITH
0
------------------------------------------------------------
8 SHARED DISPOSITIVE POWER
1,956,527
------------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
1,956,527
-----------------------------------------------------------------------------
10 CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
(SEE INSTRUCTIONS) [ ]
-----------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
9.41%
-----------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
PN
-----------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT!
Page 4 of 18 Pages
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CUSIP NO. 02043Q107 13G PAGE 5 OF 18 PAGES
------------------- ------------------
-----------------------------------------------------------------------------
1 NAMES OF REPORTING PERSONS
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
ARCH Venture Partners V, LLC
-----------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
(a) [ ]
(b) [ ]
-----------------------------------------------------------------------------
3 SEC USE ONLY
-----------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
Delaware
-----------------------------------------------------------------------------
5 SOLE VOTING POWER
0
NUMBER OF ------------------------------------------------------------
SHARES 6 SHARED VOTING POWER
BENEFICIALLY
OWNED BY 1,956,527
EACH
REPORTING ------------------------------------------------------------
PERSON 7 SOLE DISPOSITIVE POWER
WITH
0
------------------------------------------------------------
8 SHARED DISPOSITIVE POWER
1,956,527
-----------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
1,956,527
-----------------------------------------------------------------------------
10 CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
(SEE INSTRUCTIONS) [ ]
-----------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
9.41%
-----------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
OO
-----------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT!
*
Page 5 of 18 Pages
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CUSIP NO. 02043Q107 13G PAGE 6 OF 18 PAGES
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-----------------------------------------------------------------------------
1 NAMES OF REPORTING PERSONS
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
Steven Lazarus
-----------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
(a) [ ]
(b) [ ]
-----------------------------------------------------------------------------
3 SEC USE ONLY
-----------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
U.S.A.
-----------------------------------------------------------------------------
5 SOLE VOTING POWER
0
NUMBER OF ------------------------------------------------------------
SHARES 6 SHARED VOTING POWER
BENEFICIALLY
OWNED BY 1,956,527
EACH
REPORTING ------------------------------------------------------------
PERSON 7 SOLE DISPOSITIVE POWER
WITH
0
------------------------------------------------------------
8 SHARED DISPOSITIVE POWER
1,956,527
-----------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
1,956,527
-----------------------------------------------------------------------------
10 CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
(SEE INSTRUCTIONS) [ ]
-----------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
9.41%
-----------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
IN
-----------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT!
Page 6 of 18 Pages
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CUSIP NO. 02043Q107 13G PAGE 7 OF 18 PAGES
------------------- ------------------
-----------------------------------------------------------------------------
1 NAMES OF REPORTING PERSONS
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
Keith Crandell
-----------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
(a) [ ]
(b) [ ]
-----------------------------------------------------------------------------
3 SEC USE ONLY
-----------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
U.S.A.
-----------------------------------------------------------------------------
5 SOLE VOTING POWER
0
NUMBER OF ------------------------------------------------------------
SHARES 6 SHARED VOTING POWER
BENEFICIALLY
OWNED BY 1,956,527
EACH
REPORTING ------------------------------------------------------------
PERSON 7 SOLE DISPOSITIVE POWER
WITH
0
------------------------------------------------------------
8 SHARED DISPOSITIVE POWER
1,956,527
-----------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
1,956,527
-----------------------------------------------------------------------------
10 CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
(SEE INSTRUCTIONS) [ ]
-----------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
9.41%
-----------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
IN
-----------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT!
Page 7 of 18 Pages
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CUSIP NO. 02043Q107 13G PAGE 8 OF 18 PAGES
------------------- ------------------
-----------------------------------------------------------------------------
1 NAMES OF REPORTING PERSONS
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
Robert Nelsen
-----------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
(a) [ ]
(b) [ ]
-----------------------------------------------------------------------------
3 SEC USE ONLY
-----------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
U.S.A.
-----------------------------------------------------------------------------
5 SOLE VOTING POWER
0
NUMBER OF ------------------------------------------------------------
SHARES 6 SHARED VOTING POWER
BENEFICIALLY
OWNED BY 1,956,527
EACH
REPORTING ------------------------------------------------------------
PERSON 7 SOLE DISPOSITIVE POWER
WITH
0
------------------------------------------------------------
8 SHARED DISPOSITIVE POWER
1,956,527
-----------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
1,956,527
-----------------------------------------------------------------------------
10 CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
(SEE INSTRUCTIONS) [ ]
-----------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
9.41%
-----------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
IN
-----------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT!
Page 8 of 18 Pages
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CUSIP NO. 02043Q107 13G PAGE 9 OF 18 PAGES
------------------ ------------------
-----------------------------------------------------------------------------
1 NAMES OF REPORTING PERSONS
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)
Clinton Bybee
-----------------------------------------------------------------------------
2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)
(a) [ ]
(b) [ ]
-----------------------------------------------------------------------------
3 SEC USE ONLY
-----------------------------------------------------------------------------
4 CITIZENSHIP OR PLACE OF ORGANIZATION
U.S.A.
-----------------------------------------------------------------------------
5 SOLE VOTING POWER
0
NUMBER OF ------------------------------------------------------------
SHARES 6 SHARED VOTING POWER
BENEFICIALLY
OWNED BY 1,956,527
EACH
REPORTING ------------------------------------------------------------
PERSON 7 SOLE DISPOSITIVE POWER
WITH
0
------------------------------------------------------------
8 SHARED DISPOSITIVE POWER
1,956,527
-----------------------------------------------------------------------------
9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON
1,956,527
-----------------------------------------------------------------------------
10 CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES
(SEE INSTRUCTIONS) [ ]
-----------------------------------------------------------------------------
11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
9.41%
-----------------------------------------------------------------------------
12 TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
IN
-----------------------------------------------------------------------------
*SEE INSTRUCTIONS BEFORE FILLING OUT!
Page 9 of 18 Pages
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CUSIP NO. 02043Q107 13G PAGE 10 OF 18 PAGES
------------------- -------------------
Schedule 13G
Item 1(a). Name of Issuer: Alnylam Pharmaceuticals, Inc. (the "Issuer").
Item 1(b). Address of Issuer's Principal Executive Offices: 300 Third
Street, Cambridge, Massachusetts 02142
Item 2(a). Names of Persons Filing: ARCH Venture Fund V, L.P. ("ARCH
Venture Fund V"); ARCH V Entrepreneurs Fund, L.P. ("ARCH V
Entrepreneurs Fund"); ARCH Venture Partners V, L.P. ("AVP V LP");
ARCH Venture Partners V, LLC ("AVP V LLC"); (collectively, the
"Reporting Entities" and individually, each a "Reporting Entity")
and Steven Lazarus ("Lazarus"), Keith Crandell ("Crandell"), Robert
Nelsen ("Nelsen") and Clinton Bybee ("Bybee") (collectively, the
"Managing Directors" and individually, each a "Managing Director").
The Reporting Entities and the Managing Directors collectively are
referred to as the "Reporting Persons".
Item 2(b). Address of Principal Business Office or, if None, Residence:
8725 W. Higgins Road, Suite 290, Chicago, IL 60631.
Item 2(c). Citizenship: ARCH Venture Fund V, ARCH V Entrepreneur Fund,
and AVP V LP are limited partnerships organized under the laws of
the State of Delaware. AVP V LLC is a limited liability company
organized under the laws of the State of Delaware. Each Managing
Director is a US citizen.
Item 2(d). Title of Class of Securities: Common Stock, $.01 par value
(the "Common Stock").
Item 2(e). CUSIP Number: 02043Q107
Item 3. If this statement is filed pursuant to Sections 240.13d-1(b) or
240.13d-2(b) or (c), check whether the person filing is a:
Not Applicable.
Item 4. Ownership.
(a) Amount beneficially owned:
ARCH Venture Fund V is the record owner of 1,944,755 shares of
Common Stock (the "ARCH Venture Fund V Shares") as of December
31, 2004. ARCH V Entrepreneur Fund is the record owner of
11,772 shares of Common Stock (the "ARCH V Entrepreneur Fund
Shares" and, together with the ARCH Venture Fund V Shares, the
"Record Shares") as of December 31, 2004. AVP V LP is the sole
general partner of ARCH Venture Fund V and ARCH V
Entrepreneurs Fund. AVP V LLC is the sole
Page 10 of 18 Pages
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CUSIP NO. 02043Q107 13G PAGE 11 OF 18 PAGES
------------------- -------------------
general partner of AVP V LP. By virtue of their relationship
as affiliated entities who have overlapping general partners
and managing directors, each Reporting Entity may be deemed to
share the power and direct the disposition and vote of the
Record Shares. As individual general partners or managing
directors of each of AVP V LLC and AVP V LP, each Managing
Director may also be deemed to share the power and direct the
disposition and vote of the Record Shares.
(b) Percent of class:
Reporting entities and Reporting Persons: 9.41%, and is
calculated based 20,801,208 shares outstanding as of December
31, 2004, which is the sum of (per guidance from the company)
the amount reported of 20,085,590 shares of Common Stock
reported to be outstanding in the Issuer's Form 10-Q filed
with the Securities and Exchange Commission on November 15,
2004 and additional shares (715,618) issued per 8-K filed on
December 31, 2004.
(c) Number of shares as to which the person has:
(i) Sole power to vote or to direct the vote:
0 shares for each Reporting Person
(ii) Shared power to vote or to direct the vote:
Each of the Reporting Persons: 1,956,527
(iii) Sole power to dispose or to direct the disposition of:
0 shares for each Reporting Person
(iv) Shared power to dispose or to direct the disposition of:
Each of the Reporting Persons: 1,956,527
Each Reporting Person disclaims beneficial ownership of such shares
of Common Stock except for the shares, if any, such Reporting Person
holds of record.
Item 5. Ownership of Five Percent or Less of a Class.
Not Applicable.
Item 6. Ownership of More than Five Percent on Behalf of Another Person.
Not Applicable.
Item 7. Identification and Classification of the Subsidiary which
Acquired the Security Being Reported on By the Parent Holding
Company or Control Person.
Page 11 of 18 Pages
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CUSIP NO. 02043Q107 13G PAGE 12 OF 18 PAGES
------------------- -------------------
Not Applicable.
Item 8. Identification and Classification of Members of the Group.
Not Applicable. The Reporting Persons expressly disclaim membership
in a "group" as used in Rule 13d-1(b)(ii)(J).
Item 9. Notice of Dissolution of Group.
Not Applicable.
Item 10. Certification.
Not Applicable. This statement on Schedule 13G is not filed pursuant
to Section 240.13d-1(b) nor Section 240.13d-1(c).
Page 12 of 18 Pages
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CUSIP NO. 02043Q107 13G PAGE 13 OF 18 PAGES
------------------- -------------------
SIGNATURES
After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.
Dated: February 11, 2005 ARCH VENTURE FUND V, L.P.
By: ARCH Venture Partners V, L.P.
its General Partner
By: ARCH Venture Partners V, LLC
its General Partner
By: *
-----------------------
Steven Lazarus
Managing Director
ARCH V ENTREPRENEURS FUND, L.P.
By: ARCH Venture Partners V, L.P.
its General Partner
By: ARCH Venture Partners V, LLC
its General Partner
By: *
-----------------------
Steven Lazarus
Managing Director
ARCH VENTURE PARTNERS V, L.P.
By: ARCH Venture Partners V, LLC
its General Partner
By: *
-----------------------
Steven Lazarus
Managing Director
ARCH VENTURE PARTNERS V, LLC
By: *
------------------------
Steven Lazarus
Managing Director
Page 13 of 18 Pages
------------------- -------------------
CUSIP NO. 02043Q107 13G PAGE 14 OF 18 PAGES
------------------- -------------------
*
------------------------
Steven Lazarus
*
------------------------
Keith Crandell
*
------------------------
Robert Nelsen
*
------------------------
Clinton Bybee
* By: /s/ Mark McDonnell
---------------------
Mark McDonnell as
Attorney-in-Fact
This Schedule 13G was executed by Mark McDonnell pursuant to Powers of Attorney
attached hereto as Exhibit 2 and incorporated herein by reference.
Page 14 of 18 Pages