UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                    FORM 8-K

                                 CURRENT REPORT

                     Pursuant to Section 13 or 15(d) of the
                         Securities Exchange Act of 1934

                Date of Report (Date of earliest event reported)
                                  May 20, 2009

                           HEMISPHERX BIOPHARMA, INC.
             (Exact name of registrant as specified in its charter)

                           Delaware 0-27072 52-0845822
         (state or other jurisdiction (Commission File (I.R.S. Employer
                  of incorporation) Number) Identification No.)

              1617 JFK Boulevard, Philadelphia, Pennsylvania 19103
               (Address of principal executive offices) (Zip Code)

       Registrant's telephone number, including area code: (215) 988-0080


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                 (former name or former address, if changed since last report)

Check  the  appropriate  box  below  if the  Form  8-K  filing  is  intended  to
simultaneously  satisfy the filing obligation of the registrant under any of the
following provisions (see General Instruction A.2. below):

|_| Written communications pursuant to Rule 425 under the Securities Act (17 CFR
230.425)

|_| Soliciting material pursuant to Rule 14a-12 under the Securities Act (17 CFR
230.14a-12)

|_| Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange
Act (17 CFR 240-14d-2(b))

|_| Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange
Act (17CFR 240-13e-4(c))








Section 5 - Corporate Governance and Management

Item 5.02  Departure of Directors or Certain  Officers;  Election of  Directors;
Appointment of Certain Officers; Compensatory Arrangements of Certain Officers.

On May 20,  2009,  our  Board of  Directors  awarded  bonuses  to the  following
executives in relation to 2008  corporate  goals and  objectives:  W.A.  Carter,
M.D., CEO and Chairman of the Board, was awarded $300,000 and Dr. David Strayer,
Chief Medical Officer, was awarded $150,000.

The  Compensation  Committee  and Board of Directors  reviewed  corporate  goals
established in March 2008 and determined that significant progress has been made
in terms of 1) preparation  and filing the Ampligen(R) NDA with the Federal Drug
Administration;  and 2)  with  the  receipt  of  recent  funding  for  operating
activities,  funds previously reserved for operating activities could be used to
pay 2008 bonus.



Section 9 - Financial Statements and Exhibits

Item 9.01 Financial Statements and Exhibits.

(d)    Exhibits

The following Exhibit is filed as part of this report:

Exhibit No.    Description
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Exhibit 99.1 Press Release dated May 27, 2009.


                                   SIGNATURES

Pursuant  to the  requirements  of the  Securities  Exchange  Act of  1934,  the
registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned hereunto duly authorized.

                                          HEMISPHERX BIOPHARMA, INC.

May 27, 2009                              By:  /s/ William A. Carter
                                          -------------------------------------
                                          William A. Carter, M.D.
                                          Chief Executive Officer





                                                                    Exhibit 99.1




Dianne Will                                          Mark Collinson
Hemispherx Biopharma, Inc.                           CCG Investor Relations
518-398-6222                                         310-477-9800
ir@hemispherx.net



             Hemispherx Announces Payment of 2008 Executive Bonuses

Philadelphia,  PA - May 27, 2009 - Hemispherx  Biopharma,  Inc. (NYSE AMEX: HEB)
announced today that on May 20, 2009, our Board of Directors  awarded bonuses to
the following  executives in relation to 2008  corporate  goals and  objectives:
W.A.  Carter,  M.D., CEO and Chairman of the Board, was awarded $300,000 and Dr.
David Strayer, Chief Medical Officer, was awarded $150,000.

The  Compensation  Committee  and Board of Directors  reviewed  corporate  goals
established in March 2008 and determined that significant progress has been made
in terms of 1) preparation  and filing the Ampligen(R) NDA with the Federal Drug
Administration;  and 2)  with  the  receipt  of  recent  funding  for  operating
activities,  funds previously reserved for operating activities could be used to
pay 2008 bonus.

About Hemispherx Biopharma

Hemispherx  Biopharma,  Inc.  is a  specialty  pharma  company  engaged  in  the
manufacture  and clinical  development  of new drug  entities  for  treatment of
seriously debilitating disorders. Hemispherx's flagship products include Alferon
N Injection(R)  (FDA approved for a category of sexually  transmitted  diseases)
and the experimental  therapeutics  Ampligen(R) and Oragens(R).  Ampligen(R) and
Oragens(R) represent experimental RNA nucleic acids being developed for globally
important debilitating diseases and disorders of the immune system. Hemispherx's
platform  technology  includes  large and small agent  components  for potential
treatment  of  various  severely  debilitating  and life  threatening  diseases.
Hemispherx has in excess of 50 issued patents  comprising its core  intellectual
property estate and a fully commercialized product (Alferon N Injection(R)). The
Company  wholly  owns and  exclusively  operates a GMP  certified  manufacturing
facility in the United  States for  commercial  products.  For more  information
please  visit  http://www.hemispherx.net  Information  contained  in  this  news
release other than historical information,  should be considered forward-looking
and is subject to various  risk factors and  uncertainties.  For  instance,  the
strategies and operations of Hemispherx  involve risk of  competition,  changing
market conditions, change in laws and regulations affecting these industries and
numerous  other factors  discussed in this release and in the Company's  filings
with  the  Securities  and  Exchange  Commission.  Any  specifically  referenced
investigational  drugs and  associated  technologies  of the Company  (including
Ampligen(R), Alferon LDO and Oragens) are experimental in nature and as such are
not designated safe and effective by a regulatory  authority for general use and
are  legally   available  only  through  clinical  trials  with  the  referenced
disorders. The forward-looking statements represent the Company's judgment as of
the  date of this  release.  The  Company  disclaims,  however,  any  intent  or
obligation to update these forward-looking statements. Clinical trials for other
potential  indications of the approved  biologic  Alferon N Injection(R)  do not
imply that the product will ever be specifically approved commercially for these
other  treatment  indications.  Similarly,  the completion of NDA filing process
with  Ampligen(R)  does  not  imply  that  the  product  will  ever be  approved
commercially.
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