14A
                                 (Rule 14a-101)
                     INFORMATION REQUIRED IN PROXY STATEMENT
                            SCHEDULE 14A INFORMATION
                    Proxy Statement Pursuant to Section 14(a)
                     of the Securities Exchange Act of 1934

Filed by the  Registrant  [ X ]
Filed by a Party other than the  Registrant  [  ]
Check the appropriate box:
[ ]  Preliminary Proxy Statement
[ ]  Confidential,  for  Use  of the  Commission  Only  (as  Permitted  by  Rule
     14a-6(e)(2))
[ ] Definitive  Proxy  Statement
[X]  Definitive  Additional Materials
[ ]  Solicitation  Material  Pursuant to Rule 14a-11(c) or rule 14a-12

                           Hemispherx Biopharma, Inc.
              ------------------------------------------------
              (Name of Registrant as Specified in its Charter)

    (Name of Person(s) Filing Proxy Statement, if Other Than the Registrant)

Payment of Filing Fee (Check the appropriate box):

[x]      No fee required.

[ ]      Fee computed on table below per Exchange Act Rules 14a-6(i)(1)
         and 0-11.

         Title  of each  class  of  securities  to  which  transaction  applies:
         Aggregate number of securities to which transaction  applies:  Per unit
         price or other  underlying  value of transaction  computed  pursuant to
         Exchange Act Rule 0-11:

         Proposed maximum aggregate value of transaction:
                                                          ---------------------
         5)       Total fee paid:
                                  -------------------

[ ]      Fee paid previously with preliminary materials.

[        ] Check box if any part of the fee is offset as  provided  by  Exchange
         Act Rule  0-11(a)(2)  and identify the filing for which the  offsetting
         fee was paid  previously.  Identify the previous filing by registration
         statement number, or the Form or Schedule and the date of its filing.

         (1)      Amount Previously Paid:

         (2)      Form, Schedule or Registration Statement No.:
                                                             ------------------
         (3)      Filing Party:

         (4)      Date Filed:





                           HEMISPHERX BIOPHARMA, INC.


                                PLEASE VOTE NOW!

                                                               October 17, 2008


Dear Hemispherx Stockholder:

We  reconvened  our  annual  stockholders'  meeting on  October  17,  2008 after
adjourning  the original  meeting on September 17, 2008,  but had to adjourn the
meeting again because the required  quorum of a majority of the shares  eligible
to vote at the meeting still was not present. The further adjourned meeting will
be held on Tuesday,  November 11, 2008,  at 10:00 a.m. at the Crown Plaza Hotel,
1800 Market Street, Philadelphia Pennsylvania 19103.

IF YOU DID NOT VOTE, PLEASE BE SURE TO VOTE.

The record date  remains  July 21,  2008.  The purposes for which the meeting is
being held  remain the same as those  listed in our Notice of Annual  Meeting of
August 1, 2008.

Please be advised  that,  to assure that the  meeting can be held,  our Board of
Directors  has amended our By-Laws to reduce the quorum for this  meeting from a
majority to 44% in voting power of the  outstanding  shares of stock entitled to
vote at the  meeting.  The  reduced  quorum  relates  solely to the 2008  Annual
Stockholders'  Meeting.  The  Company  will  continue  to solicit  proxies in an
attempt to receive  votes from a majority of the shares  eligible to vote at the
meeting.

For your convenience we have enclosed another proxy card and return envelope.

If you have any questions,  please call MacKenzie Partners,  Inc.,  toll-free at
(800) 322-2885 or collect at (212) 929-5500.

         Thank you in advance for voting promptly.

                                                     Sincerely,

                                                     Board of Directors
                                                     Hemispherx Biopharma, Inc.


Corporate Headquarters
______________________________________________________________________________
One Penn Center, 1617 JFK Blvd, Philadelphia, PA 19103      www.hemispherx.net
t: 215-988-0080   f: 215-988-1739

Manufacturing
______________________________________________________________________________
783 Jersey Avenue, New Brunswick, NJ 08901
t: 732-249-3250   f: 732-249-6895





                           HEMISPHERX BIOPHARMA, INC.
                  THE ADJOURNED ANNUAL MEETING OF STOCKHOLDERS
                                NOVEMBER 11, 2008

           THIS PROXY IS SOLICTED ON BEHALF OF THE BOARD OF DIRECTORS

The undersigned  hereby  appoints  William A. Carter and Ransom W. Etheridge and
each of them,  with full power of  substitution,  as proxies  to  represent  the
undersigned at the Adjourned  Annual Meeting of  Stockholders  to be held at the
Crown Plaza Hotel,  1800 Market Street,  Philadelphia,  Pennsylvania  19103,  on
Tuesday,  November  11,  2008,  at 10:00  a.m.  local  time  and at any  further
adjournment thereof, and to vote all of the shares of common stock of Hemispherx
Biopharma, Inc. the undersigned would be entitled to vote if personally present,
upon the following matters:

Please mark box in blue or black ink.

1.   Proposal No.1-Election of Directors.

     Nominees: William A. Carter, Richard C. Piani, Tom Equels,
               William M. Mitchell and  Iraj-Eqhbal Kiani.

[ ] For all nominees (except as marked to the contrary below)
[ ] Authority Withheld as to all Nominees

(INSTRUCTION: TO WITHHOLD AUTHORITY TO VOTE FOR ANY INDIVIDUAL NOMINEE, STRIKE A
LINE THROUGH THE NOMINEE'S NAME)


William A. Carter  Richard C. Piani   Tom Equels

William M. Mitchell    Iraj-Eqhbal Kiani

2.   Proposal No. 2-Ratification of the selection of McGladrey & Pullen, LLP,
     as independent registered public accounting firm of Hemispherx Biopharma,
     Inc. for the year ending December 31, 2008.

    [ ]For               [ ]Against                [ ]Abstain

3.   Proposal No. 3 - To approve the issuance of our common stock to comply
     with AMEX company guide section 713.

    [ ]For               [ ]Against                [ ] Abstain

     In their  discretion,  the proxies are  authorized  to vote upon such other
business as may properly come before the meeting.






     THE SHARES  REPRESENTED BY THIS PROXY WILL BE VOTED AS DIRECTED.  THE BOARD
RECOMMENDS  A VOTE  "FOR" ALL  DIRECTORS  AND "FOR"  ITEMS  NOS.  2 AND 3. IF NO
CONTRARY  INSTRUCTION  IS GIVEN,  THE SHARES  WILL BE VOTED FOR THE  ELECTION OF
WILLIAM A.  CARTER,  RICHARD C.  PIANI,  TOM  EQUELS,  WILLIAM A.  MITCHELL  AND
IRAJ-EQHBAL  KIANI  AS  DIRECTORS,  FOR  PROPOSALS  NO.S  2 AND 3  AND,  IN  THE
DISCRETION OF THE PROXIES,  ON ALL OTHER  MATTERS  PROPERLY  BROUGHT  BEFORE THE
ADJOURNED ANNUAL MEETING.


     Please date,  sign as name  appears at left,  and return  promptly.  If the
          stock is registered  in the name of two or more  persons,  each should
          sign.   When  signing  as  Corporate   Officer,   Partner,   Executor,
          Administrator,  Trustee,  or Guardian,  please give full title. Please
          note any change in your address alongside the address as it appears in
          the Proxy.

                                   Dated:
                                        ____________________________________

                                        ____________________________________
                                         Signature

                                        ____________________________________
                                        (Print Name)

     SIGN, DATE AND RETURN PROXY CARD PROMPTLY USING THE ENCLOSED ENVELOPE