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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549



                                    FORM 8-K

                                 CURRENT REPORT

                       Pursuant to Section 13 or 15(d) of
                       the Securities Exchange Act of 1934

                Date of report (Date of earliest event reported):
                           July 8, 2005 (July 8, 2005)

                           HEMISPHERX BIOPHARMA, INC.
               (Exact Name of Registrant as Specified in Charter)

                           Delaware 0-27072 52-0845822
             (State or Other Jurisdiction (Commission (IRS Employer
               of Incorporation) File Number) Identification No.)

              1617 JFK Boulevard, Philadelphia, Pennsylvania, 19103
          (Address of Principal Executive Offices, including Zip Code)

       Registrant's telephone number, including area code: (215) 988-0080

                                 Not Applicable
          (Former Name or Former Address, if Changed Since Last Report)

     Check the appropriate box below if the Form 8-K filing is intended to
simultaneously satisfy the filing obligation of the registrant under any of the
           following provisions (see General Instruction A.2. below):

[    ] Written communications  pursuant to Rule 425 under the Securities Act (17
     CFR 230.425)

[    ]  Soliciting  material  pursuant to Rule 14a-12 under the Exchange Act (17
     CFR 240.14a-12)

[    ]  Pre-commencement  communications  pursuant  to Rule  14d-2(b)  under the
     Exchange Act (17 CFR 240.14d-2(b))

[    ]  Pre-commencement  communications  pursuant  to Rule  13e-4(c)  under the
     Exchange Act (17 CFR 240.13e-4(c))

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Item 1.01.        Entry into a Material Definitive Agreement.
Item 3.02         Unregistered Sales of Equity Securities

On July 8, 2005,  Hemispherx  Biopharma,  Inc.. (the  "Company")  entered into a
Common Stock Purchase Agreement ("Purchase  Agreement") with Fusion Capital Fund
II, LLC, ("Fusion  Capital").  Pursuant to the terms of the Purchase  Agreement,
Fusion  Capital has agreed to purchase from the Company up to $20,000,000 of the
Company's common stock over a period of  approximately  twenty-five (25) months.
Pursuant to the terms of a Registration  Rights  Agreement,  dated as of July 8,
2005,  the Company agreed to file a  registration  statement (the  "Registration
Statement")  with the  Securities  and Exchange  Commission  covering the shares
which  are  issued to or may be issued  to  Fusion  Capital  under the  Purchase
Agreement.  Once the Registration  Statement has been declared  effective,  each
trading day during the term of the Purchase  Agreement the Company has the right
to sell to Fusion  Capital  up to  $40,000 of the  Company's  common  stock at a
purchase price equal to the lower of the lowest trade price of Company's  common
stock on such date or the  arithmetic  average of the three lowest closing trade
prices of the Company's common stock during the immediately preceding 12 trading
day period..  At the Company's option under certain  conditions,  Fusion Capital
can be required  to  purchase  greater  amounts of common  stock  during a given
period In  connection  with entering  into the Purchase  Agreement,  the Company
issued to Fusion Capital  402,798 shares of its common stock.  This offering was
made pursuant to an exemption from registration  provided by Section 4(2) of the
Securities Act of 1933, as amended.

The Company anticipates using the proceeds from this financing to extend its New
Brunswick  facility for the production of Ampligen(R)  and Alferon N injections,
as well as for general corporate purposes.

A copy of the Common  Stock  Purchase  Agreement  is attached  hereto as Exhibit
10.1,  and a copy of the  Registration  Rights  Agreement is attached  hereto as
Exhibit 10.2.








Item 9.01. Financial Statements and Exhibits.

      (c) Exhibits:

       10.1          Common Stock Purchase Agreement, dated July 8, 2005
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       10.2          Registration Rights Agreement, dated July 8, 2005
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                                                         Signatures

         Pursuant to the requirements of the Securities Exchange Act of 1934, as
amended, the registrant has caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.


Date:  July 8, 2005

                                                 HEMISPHERX BIOPHARMA, INC.

                                                 /s/ William A. Carter
                                                 ------------------------------
                                                Name: William A. Carter, M.D.
                                                Title:Chief Executive Officer