UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                  SCHEDULE 13D

                    UNDER THE SECURITIES EXCHANGE ACT OF 1934
                                 AMENDMENT NO. 4

                            Interpharm Holdings, Inc.
--------------------------------------------------------------------------------
                                (Name of Company)

                          Common Stock, $0.01 par value
--------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                    460588106
--------------------------------------------------------------------------------
                      (CUSIP Number of Class of Securities)

          Joan P. Neuscheler                         Gloria M. Skigen
  Tullis-Dickerson Capital Focus III, L.P.        Martin, Lucas & Chioffi
  c/o Tullis-Dickerson Partners III, L.L.C.          177 Broad Street
       Two Greenwich Plaza, 4th Fl.                 Stamford, CT 06901
          Greenwich, CT 06830                         (203) 973-5222
            (203) 629-8700

--------------------------------------------------------------------------------
                  (Name, Address and Telephone Number of Person
                Authorized to Receive Notices and Communications)

                                   May 1, 2008
--------------------------------------------------------------------------------
                          (Date of Event which Requires
                            Filing of this Schedule)

If the filing person has previously filed a statement on Schedule 13G to report
the acquisition that is the subject of this Schedule 13D, and is filing this
schedule because of Sections 240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check
the following box. [ ]

NOTE: Schedules filed in paper format shall include a signed original and five
copies of the schedule, including all exhibits. See ss.240.13d-7 for other
parties to whom copies are to be sent. * The remainder of this cover page shall
be filled out for a reporting person's initial filing on this form with respect
to the subject class of securities, and for any subsequent amendment containing
information which would alter disclosures provided in a prior cover page. The
information required on the remainder of this cover page shall not be deemed to
be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934
("ACT") or otherwise subject to the liabilities of that section of the Act but
shall be subject to all other provisions of the Act (however, SEE the NOTES).




                                 SCHEDULE 13D/A

--------------------------------------------------------------------------------
CUSIP NO.      460588106                               PAGE 2 OF 11 PAGES
--------------------------------------------------------------------------------

--------------------------------------------------------------------------------
    1     NAME OF REPORTING PERSON
          I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

          Tullis-Dickerson Capital Focus III, L.P. IRS # 06-1621801
--------------------------------------------------------------------------------
    2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP         (a) [x]
                                                                   (b) [ ]
--------------------------------------------------------------------------------
    3     SEC USE ONLY
--------------------------------------------------------------------------------
    4     SOURCE OF FUNDS*

          WC
--------------------------------------------------------------------------------
    5     CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED
          PURSUANT TO ITEMS 2(d) or 2(e)                               [ ]
--------------------------------------------------------------------------------
    6     CITIZENSHIP OR PLACE OF ORGANIZATION

          Delaware, United States of America
--------------------------------------------------------------------------------
                 7      SOLE VOTING POWER

                        0
                ----------------------------------------------------------------
NUMBER OF        8      SHARED VOTING POWER
SHARES
BENEFICIALLY            568,647 shares of Common Stock;
OWNED BY
EACH                    2,281,914 shares of Common Stock issuable upon exercise
REPORTING               of the Amended and Restated Warrants;
PERSON WITH
                        10,526,316 shares of Common Stock issuable upon
                        conversion of the Series D-1 Preferred Stock;

                        877,194 shares of Common Stock issuable upon
                        conversion of the Convertible Notes; and

                        307,017 shares of Common Stock issuable upon
                        conversion of the Note Warrants (1)
                ----------------------------------------------------------------
                 9      SOLE DISPOSITIVE POWER

                        0
                ----------------------------------------------------------------
                 10     SHARED DISPOSITIVE POWER

                        568,647 shares of Common Stock;

                        2,281,914 shares of Common Stock issuable upon exercise
                        of the Amended and Restated Warrants; and

                        10,526,316 shares of Common Stock issuable upon
                        conversion of the Series D-1 Preferred Stock;

                        877,194 shares of Common Stock issuable upon
                        conversion of the Convertible Notes; and

                        307,017 shares of Common Stock issuable upon
                        conversion of the Note Warrants (1)
--------------------------------------------------------------------------------
    11    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH PERSON

                        568,647 shares of Common Stock;

                        2,281,914 shares of Common Stock issuable upon exercise
                        of the Amended and Restated Warrants; and

                        10,526,316 shares of Common Stock issuable upon
                        conversion of the Series D-1 Preferred Stock;

                        877,194 shares of Common Stock issuable upon
                        conversion of the Convertible Notes; and

                        307,017 shares of Common Stock issuable upon
                        conversion of the Note Warrants (1))
--------------------------------------------------------------------------------
    12    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
          CERTAIN SHARES*                                                [ ]
--------------------------------------------------------------------------------
    13    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

          18% (see Item 5)(1)
--------------------------------------------------------------------------------
    14    TYPE OF REPORTING PERSON*

          PN
--------------------------------------------------------------------------------

-----------------------
(1) Does not include shares of Common Stock (including shares of Common Stock
and shares of Common Stock issuable upon the conversion of preferred stock and
exercise of warrants and options) held by parties to (i) the Irrevocable Proxy
Agreement other than the Reporting Persons, as discussed in Item 4 of the
Amendment No. 1 and (ii) the Proceeds Sharing Agreement, other than the
Reporting Persons, as discussed in Item 4 of the Amendment No. 3.



                                 SCHEDULE 13D/A

--------------------------------------------------------------------------------
CUSIP NO.      460588106                               PAGE 3 OF 11 PAGES
--------------------------------------------------------------------------------

--------------------------------------------------------------------------------
    1     NAME OF REPORTING PERSON
          I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

          Tullis-Dickerson Partners III, L.L.C. IRS # 06-1621800
--------------------------------------------------------------------------------
    2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP         (a) [x]
                                                                   (b) [ ]
--------------------------------------------------------------------------------
    3     SEC USE ONLY
--------------------------------------------------------------------------------
    4     SOURCE OF FUNDS*

          AF
--------------------------------------------------------------------------------
    5     CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED
          PURSUANT TO ITEMS 2(d) or 2(e)                               [ ]
--------------------------------------------------------------------------------
    6     CITIZENSHIP OR PLACE OF ORGANIZATION

          Delaware, United States of America
--------------------------------------------------------------------------------
                 7      SOLE VOTING POWER

                        0
                ----------------------------------------------------------------
NUMBER OF        8      SHARED VOTING POWER
SHARES
BENEFICIALLY            568,647 shares of Common Stock;
OWNED BY
EACH                    2,281,914 shares of Common Stock issuable upon exercise
REPORTING               of the Amended and Restated Warrants;
PERSON WITH
                        10,526,316 shares of Common Stock issuable upon
                        conversion of the Series D-1 Preferred Stock;

                        877,194 shares of Common Stock issuable upon
                        conversion of the Convertible Notes; and

                        307,017 shares of Common Stock issuable upon
                        conversion of the Note Warrants (1)
                ----------------------------------------------------------------
                 9      SOLE DISPOSITIVE POWER

                        0
                ----------------------------------------------------------------
                 10     SHARED DISPOSITIVE POWER

                        568,647 shares of Common Stock;

                        2,281,914 shares of Common Stock issuable upon exercise
                        of the Amended and Restated Warrants; and

                        10,526,316 shares of Common Stock issuable upon
                        conversion of the Series D-1 Preferred Stock;

                        877,194 shares of Common Stock issuable upon
                        conversion of the Convertible Notes; and

                        307,017 shares of Common Stock issuable upon
                        conversion of the Note Warrants (1)
--------------------------------------------------------------------------------
    11    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH PERSON

                        568,647 shares of Common Stock;

                        2,281,914 shares of Common Stock issuable upon exercise
                        of the Amended and Restated Warrants; and

                        10,526,316 shares of Common Stock issuable upon
                        conversion of the Series D-1 Preferred Stock;

                        877,194 shares of Common Stock issuable upon
                        conversion of the Convertible Notes; and

                        307,017 shares of Common Stock issuable upon
                        conversion of the Note Warrants (1)
--------------------------------------------------------------------------------
    12    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
          CERTAIN SHARES*                                                [ ]
--------------------------------------------------------------------------------
    13    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

          18% (see Item 5)(1)
--------------------------------------------------------------------------------
    14    TYPE OF REPORTING PERSON*

          OO
--------------------------------------------------------------------------------

-----------------------
(1) Does not include shares of Common Stock (including shares of Common Stock
and shares of Common Stock issuable upon the conversion of preferred stock and
exercise of warrants and options) held by parties to (i) the Irrevocable Proxy
Agreement other than the Reporting Persons, as discussed in Item 4 of the
Amendment No. 1 and (ii) the Proceeds Sharing Agreement, other than the
Reporting Persons, as discussed in Item 4 of the Amendment No. 3.



                                 SCHEDULE 13D/A

--------------------------------------------------------------------------------
CUSIP NO.      460588106                               PAGE 4 OF 11 PAGES
--------------------------------------------------------------------------------

--------------------------------------------------------------------------------
    1     NAME OF REPORTING PERSON
          I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

          Joan P. Neuscheler
--------------------------------------------------------------------------------
    2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP         (a) [x]
                                                                   (b) [ ]
--------------------------------------------------------------------------------
    3     SEC USE ONLY
--------------------------------------------------------------------------------
    4     SOURCE OF FUNDS*

          AF
--------------------------------------------------------------------------------
    5     CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED
          PURSUANT TO ITEMS 2(d) or 2(e)                               [ ]
--------------------------------------------------------------------------------
    6     CITIZENSHIP OR PLACE OF ORGANIZATION

          United States of America
--------------------------------------------------------------------------------
                 7      SOLE VOTING POWER

                        0
                ----------------------------------------------------------------
NUMBER OF        8      SHARED VOTING POWER
SHARES
BENEFICIALLY            568,647 shares of Common Stock;
OWNED BY
EACH                    2,281,914 shares of Common Stock issuable upon exercise
REPORTING               of the Amended and Restated Warrants;
PERSON WITH
                        10,526,316 shares of Common Stock issuable upon
                        conversion of the Series D-1 Preferred Stock;

                        877,194 shares of Common Stock issuable upon
                        conversion of the Convertible Notes; and

                        307,017 shares of Common Stock issuable upon
                        conversion of the Note Warrants (1)
                ----------------------------------------------------------------
                 9      SOLE DISPOSITIVE POWER

                        0
                ----------------------------------------------------------------
                 10     SHARED DISPOSITIVE POWER

                        568,647 shares of Common Stock;

                        2,281,914 shares of Common Stock issuable upon exercise
                        of the Amended and Restated Warrants; and

                        10,526,316 shares of Common Stock issuable upon
                        conversion of the Series D-1 Preferred Stock;

                        877,194 shares of Common Stock issuable upon
                        conversion of the Convertible Notes; and

                        307,017 shares of Common Stock issuable upon
                        conversion of the Note Warrants (1)
------------------------------------------------------------------------------
    11    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH PERSON

                        568,647 shares of Common Stock;

                        2,281,914 shares of Common Stock issuable upon exercise
                        of the Amended and Restated Warrants; and

                        10,526,316 shares of Common Stock issuable upon
                        conversion of the Series D-1 Preferred Stock;

                        877,194 shares of Common Stock issuable upon
                        conversion of the Convertible Notes; and

                        307,017 shares of Common Stock issuable upon
                        conversion of the Note Warrants (1)
--------------------------------------------------------------------------------
    12    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
          CERTAIN SHARES*                                                [ ]
--------------------------------------------------------------------------------
    13    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

          18% (see Item 5)(1)
--------------------------------------------------------------------------------
    14    TYPE OF REPORTING PERSON*

          IN
--------------------------------------------------------------------------------

-----------------------
(1) Does not include shares of Common Stock (including shares of Common Stock
and shares of Common Stock issuable upon the conversion of preferred stock and
exercise of warrants and options) held by parties to (i) the Irrevocable Proxy
Agreement other than the Reporting Persons, as discussed in Item 4 of the
Amendment No. 1 and (ii) the Proceeds Sharing Agreement, other than the
Reporting Persons, as discussed in Item 4 of the Amendment No. 3.





                                 SCHEDULE 13D/A

--------------------------------------------------------------------------------
CUSIP NO.      460588106                               PAGE 5 OF 11 PAGES
--------------------------------------------------------------------------------

--------------------------------------------------------------------------------
    1     NAME OF REPORTING PERSON
          I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

          James L.L. Tullis
--------------------------------------------------------------------------------
    2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP         (a) [x]
                                                                   (b) [ ]
--------------------------------------------------------------------------------
    3     SEC USE ONLY
--------------------------------------------------------------------------------
    4     SOURCE OF FUNDS*

          AF
--------------------------------------------------------------------------------
    5     CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED
          PURSUANT TO ITEMS 2(d) or 2(e)                               [ ]
--------------------------------------------------------------------------------
    6     CITIZENSHIP OR PLACE OF ORGANIZATION

          United States of America
--------------------------------------------------------------------------------
                 7      SOLE VOTING POWER

                        0
                ----------------------------------------------------------------
NUMBER OF        8      SHARED VOTING POWER
SHARES
BENEFICIALLY            568,647 shares of Common Stock;
OWNED BY
EACH                    2,281,914 shares of Common Stock issuable upon exercise
REPORTING               of the Amended and Restated Warrants;
PERSON WITH
                        10,526,316 shares of Common Stock issuable upon
                        conversion of the Series D-1 Preferred Stock;

                        877,194 shares of Common Stock issuable upon
                        conversion of the Convertible Notes; and

                        307,017 shares of Common Stock issuable upon
                        conversion of the Note Warrants (1)
                ----------------------------------------------------------------
                 9      SOLE DISPOSITIVE POWER

                        0
                ----------------------------------------------------------------
                 10     SHARED DISPOSITIVE POWER

                        568,647 shares of Common Stock;

                        2,281,914 shares of Common Stock issuable upon exercise
                        of the Amended and Restated Warrants; and

                        10,526,316 shares of Common Stock issuable upon
                        conversion of the Series D-1 Preferred Stock;

                        877,194 shares of Common Stock issuable upon
                        conversion of the Convertible Notes; and

                        307,017 shares of Common Stock issuable upon
                        conversion of the Note Warrants (1)
------------------------------------------------------------------------------
    11    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH PERSON

                        568,647 shares of Common Stock;

                        2,281,914 shares of Common Stock issuable upon exercise
                        of the Amended and Restated Warrants; and

                        10,526,316 shares of Common Stock issuable upon
                        conversion of the Series D-1 Preferred Stock;

                        877,194 shares of Common Stock issuable upon
                        conversion of the Convertible Notes; and

                        307,017 shares of Common Stock issuable upon
                        conversion of the Note Warrants (1)
--------------------------------------------------------------------------------
    12    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
          CERTAIN SHARES*                                                [ ]
--------------------------------------------------------------------------------
    13    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

          18% (see Item 5)(1)
--------------------------------------------------------------------------------
    14    TYPE OF REPORTING PERSON*

          IN
--------------------------------------------------------------------------------

-----------------------
(1) Does not include shares of Common Stock (including shares of Common Stock
and shares of Common Stock issuable upon the conversion of preferred stock and
exercise of warrants and options) held by parties to (i) the Irrevocable Proxy
Agreement other than the Reporting Persons, as discussed in Item 4 of the
Amendment No. 1 and (ii) the Proceeds Sharing Agreement, other than the
Reporting Persons, as discussed in Item 4 of the Amendment No. 3.



                                 SCHEDULE 13D/A

--------------------------------------------------------------------------------
CUSIP NO.      460588106                               PAGE 6 OF 11 PAGES
--------------------------------------------------------------------------------

--------------------------------------------------------------------------------
    1     NAME OF REPORTING PERSON
          I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

          Thomas P. Dickerson
--------------------------------------------------------------------------------
    2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP         (a) [x]
                                                                   (b) [ ]
--------------------------------------------------------------------------------
    3     SEC USE ONLY
--------------------------------------------------------------------------------
    4     SOURCE OF FUNDS*

          AF
--------------------------------------------------------------------------------
    5     CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED
          PURSUANT TO ITEMS 2(d) or 2(e)                               [ ]
--------------------------------------------------------------------------------
    6     CITIZENSHIP OR PLACE OF ORGANIZATION

          United States of America
--------------------------------------------------------------------------------
                 7      SOLE VOTING POWER

                        0
                ----------------------------------------------------------------
NUMBER OF        8      SHARED VOTING POWER
SHARES
BENEFICIALLY            568,647 shares of Common Stock;
OWNED BY
EACH                    2,281,914 shares of Common Stock issuable upon exercise
REPORTING               of the Amended and Restated Warrants;
PERSON WITH
                        10,526,316 shares of Common Stock issuable upon
                        conversion of the Series D-1 Preferred Stock;

                        877,194 shares of Common Stock issuable upon
                        conversion of the Convertible Notes; and

                        307,017 shares of Common Stock issuable upon
                        conversion of the Note Warrants (1)
                ----------------------------------------------------------------
                 9      SOLE DISPOSITIVE POWER

                        0
                ----------------------------------------------------------------
                 10     SHARED DISPOSITIVE POWER

                        568,647 shares of Common Stock;

                        2,281,914 shares of Common Stock issuable upon exercise
                        of the Amended and Restated Warrants; and

                        10,526,316 shares of Common Stock issuable upon
                        conversion of the Series D-1 Preferred Stock;

                        877,194 shares of Common Stock issuable upon
                        conversion of the Convertible Notes; and

                        307,017 shares of Common Stock issuable upon
                        conversion of the Note Warrants (1)
------------------------------------------------------------------------------
    11    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH PERSON

                        568,647 shares of Common Stock;

                        2,281,914 shares of Common Stock issuable upon exercise
                        of the Amended and Restated Warrants; and

                        10,526,316 shares of Common Stock issuable upon
                        conversion of the Series D-1 Preferred Stock;

                        877,194 shares of Common Stock issuable upon
                        conversion of the Convertible Notes; and

                        307,017 shares of Common Stock issuable upon
                        conversion of the Note Warrants (1)
------------------------------------------------------------------------------
    12    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
          CERTAIN SHARES*                                                [ ]
--------------------------------------------------------------------------------
    13    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

          18% (see Item 5)(1)
--------------------------------------------------------------------------------
    14    TYPE OF REPORTING PERSON*

          IN
--------------------------------------------------------------------------------

-----------------------
(1) Does not include shares of Common Stock (including shares of Common Stock
and shares of Common Stock issuable upon the conversion of preferred stock and
exercise of warrants and options) held by parties to (i) the Irrevocable Proxy
Agreement other than the Reporting Persons, as discussed in Item 4 of the
Amendment No. 1 and (ii) the Proceeds Sharing Agreement, other than the
Reporting Persons, as discussed in Item 4 of the Amendment No. 3.



                                 SCHEDULE 13D/A

--------------------------------------------------------------------------------
CUSIP NO.      460588106                               PAGE 7 OF 11 PAGES
--------------------------------------------------------------------------------

--------------------------------------------------------------------------------
    1     NAME OF REPORTING PERSON
          I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

          Lyle A. Hohnke
--------------------------------------------------------------------------------
    2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP         (a) [x]
                                                                   (b) [ ]
--------------------------------------------------------------------------------
    3     SEC USE ONLY
--------------------------------------------------------------------------------
    4     SOURCE OF FUNDS*

          AF
--------------------------------------------------------------------------------
    5     CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED
          PURSUANT TO ITEMS 2(d) or 2(e)                               [ ]
--------------------------------------------------------------------------------
    6     CITIZENSHIP OR PLACE OF ORGANIZATION

          United States of America
--------------------------------------------------------------------------------
                 7      SOLE VOTING POWER

                        0
                ----------------------------------------------------------------
NUMBER OF        8      SHARED VOTING POWER
SHARES
BENEFICIALLY            568,647 shares of Common Stock;
OWNED BY
EACH                    2,281,914 shares of Common Stock issuable upon exercise
REPORTING               of the Amended and Restated Warrants;
PERSON WITH
                        10,526,316 shares of Common Stock issuable upon
                        conversion of the Series D-1 Preferred Stock;

                        877,194 shares of Common Stock issuable upon
                        conversion of the Convertible Notes; and

                        307,017 shares of Common Stock issuable upon
                        conversion of the Note Warrants (1)
                ----------------------------------------------------------------
                 9      SOLE DISPOSITIVE POWER

                        0
                ----------------------------------------------------------------
                 10     SHARED DISPOSITIVE POWER

                        568,647 shares of Common Stock;

                        2,281,914 shares of Common Stock issuable upon exercise
                        of the Amended and Restated Warrants; and

                        10,526,316 shares of Common Stock issuable upon
                        conversion of the Series D-1 Preferred Stock;

                        877,194 shares of Common Stock issuable upon
                        conversion of the Convertible Notes; and

                        307,017 shares of Common Stock issuable upon
                        conversion of the Note Warrants (1)
--------------------------------------------------------------------------------
    11    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH PERSON

                        568,647 shares of Common Stock;

                        2,281,914 shares of Common Stock issuable upon exercise
                        of the Amended and Restated Warrants; and

                        10,526,316 shares of Common Stock issuable upon
                        conversion of the Series D-1 Preferred Stock;

                        877,194 shares of Common Stock issuable upon
                        conversion of the Convertible Notes; and

                        307,017 shares of Common Stock issuable upon
                        conversion of the Note Warrants (1)
--------------------------------------------------------------------------------
    12    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
          CERTAIN SHARES*                                                [ ]
--------------------------------------------------------------------------------
    13    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

          18% (see Item 5)(1)
--------------------------------------------------------------------------------
    14    TYPE OF REPORTING PERSON*

          IN
--------------------------------------------------------------------------------

-----------------------
(1) Does not include shares of Common Stock (including shares of Common Stock
and shares of Common Stock issuable upon the conversion of preferred stock and
exercise of warrants and options) held by parties to (i) the Irrevocable Proxy
Agreement other than the Reporting Persons, as discussed in Item 4 of the
Amendment No. 1 and (ii) the Proceeds Sharing Agreement, other than the
Reporting Persons, as discussed in Item 4 of the Amendment No. 3.





                                 SCHEDULE 13D/A

--------------------------------------------------------------------------------
CUSIP NO.      460588106                               PAGE 8 OF 11 PAGES
--------------------------------------------------------------------------------

--------------------------------------------------------------------------------
    1     NAME OF REPORTING PERSON
          I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

          Timothy M. Buono
--------------------------------------------------------------------------------
    2     CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP         (a) [x]
                                                                   (b) [ ]
--------------------------------------------------------------------------------
    3     SEC USE ONLY
--------------------------------------------------------------------------------
    4     SOURCE OF FUNDS*

          AF
--------------------------------------------------------------------------------
    5     CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED
          PURSUANT TO ITEMS 2(d) or 2(e)                               [ ]
--------------------------------------------------------------------------------
    6     CITIZENSHIP OR PLACE OF ORGANIZATION

          United States of America
--------------------------------------------------------------------------------
                 7      SOLE VOTING POWER

                        0
                ----------------------------------------------------------------
NUMBER OF        8      SHARED VOTING POWER
SHARES
BENEFICIALLY            568,647 shares of Common Stock;
OWNED BY
EACH                    2,281,914 shares of Common Stock issuable upon exercise
REPORTING               of the Amended and Restated Warrants;
PERSON WITH
                        10,526,316 shares of Common Stock issuable upon
                        conversion of the Series D-1 Preferred Stock;

                        877,194 shares of Common Stock issuable upon
                        conversion of the Convertible Notes; and

                        307,017 shares of Common Stock issuable upon
                        conversion of the Note Warrants (1)
                ----------------------------------------------------------------
                 9      SOLE DISPOSITIVE POWER

                        0
                ----------------------------------------------------------------
                 10     SHARED DISPOSITIVE POWER

                        568,647 shares of Common Stock;

                        2,281,914 shares of Common Stock issuable upon exercise
                        of the Amended and Restated Warrants; and

                        10,526,316 shares of Common Stock issuable upon
                        conversion of the Series D-1 Preferred Stock;

                        877,194 shares of Common Stock issuable upon
                        conversion of the Convertible Notes; and

                        307,017 shares of Common Stock issuable upon
                        conversion of the Note Warrants (1)
--------------------------------------------------------------------------------
    11    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH PERSON

                        568,647 shares of Common Stock;

                        2,281,914 shares of Common Stock issuable upon exercise
                        of the Amended and Restated Warrants; and

                        10,526,316 shares of Common Stock issuable upon
                        conversion of the Series D-1 Preferred Stock;

                        877,194 shares of Common Stock issuable upon
                        conversion of the Convertible Notes; and

                        307,017 shares of Common Stock issuable upon
                        conversion of the Note Warrants (1)
--------------------------------------------------------------------------------
    12    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
          CERTAIN SHARES*                                                [ ]
--------------------------------------------------------------------------------
    13    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

          18% (see Item 5)(1)
--------------------------------------------------------------------------------
    14    TYPE OF REPORTING PERSON*

          IN
--------------------------------------------------------------------------------

-----------------------
(1) Does not include shares of Common Stock (including shares of Common Stock
and shares of Common Stock issuable upon the conversion of preferred stock and
exercise of warrants and options) held by parties to (i) the Irrevocable Proxy
Agreement other than the Reporting Persons, as discussed in Item 4 of the
Amendment No. 1 and (ii) the Proceeds Sharing Agreement, other than the
Reporting Persons, as discussed in Item 4 of the Amendment No. 3.




                                 SCHEDULE 13D/A

The Schedule 13D filed on June 6, 2006 (the "Schedule 13D") by  Tullis-Dickerson
Capital Focus III, L.P.  ("Capital Focus III"),  Tullis-Dickerson  Partners III,
L.L.C. ("Partners III"), Joan P. Neuscheler  ("Neuscheler"),  James L. L. Tullis
("Tullis"),  Thomas P. Dickerson  ("Dickerson"),  Lyle A. Hohnke  ("Hohnke") and
Timothy M. Buono  ("Buono" and together  with Capital  Focus III,  Partners III,
Neuscheler,  Tullis,  Dickerson and Hohnke, the "Reporting Persons") relating to
the common stock, par value $0.01 per share (the "Common Stock"),  of Interpharm
Holdings, Inc. (the "Issuer"), as amended by Amendment No. 1 to the Schedule 13D
filed on November  16, 2007 (the  "Amendment  No.  1"),  Amendment  No. 2 to the
Schedule 13D filed on February 29, 2008 (the  "Amendment  No. 2") and  Amendment
No. 3 to the  Schedule 13D filed on April 29, 2008 (the  "Amendment  No. 3"), is
hereby amended as set forth in this Amendment No. 4.

ITEM 4. PURPOSE OF TRANSACTION.

ITEM 4 OF THE SCHEDULE 13D IS HEREBY AMENDED TO ADD THE FOLLOWING:

On May 2, 2008 the Issuer,  Amneal  Pharmaceuticals of New York, LLC, a Delaware
limited liability  company,  ("Amneal") and certain  shareholders of the Issuer,
including, but not limited to, Capital Focus III, (the "Majority Shareholders"),
with respect to only certain  provisions  specified  therein,  entered into that
certain First  Amendment to Asset Purchase  Agreement  (the "First  Amendment to
Asset  Purchase  Agreement"),  pursuant to which the terms of the Asset Purchase
Agreement (as defined in Amendment No. 3) were amended.  None of the  provisions
with respect to which the  Majority  Shareholders  executed  the Asset  Purchase
Agreement were amended by the First Amendment to Asset Purchase Agreement.

On May 1, 2008,  Capital Focus III,  Aisling  Capital II, L.P.  ("Aisling",  and
Aisling  together  with  Capital  Focus III,  the "Series D-1  Holders"),  Ravis
Holdings I, LLC ("Ravis  Holdings"),  P&K Holdings,  LLC ("P&K  Holdings"),  Dr.
Maganlal K. Sutaria,  Perry Sutaria,  Raj Holdings I, LLC ("Raj  Holdings",  and
together  with Perry  Sutaria,  and Dr.  Maganlal  K.  Sutaria,  the "Series A-1
Holders",  and the Series A-1 Holders together with the Series D-1 Holders,  the
"Preferred  Holders"),  Raj  Sutaria,  Ravi Sutari and  Bhupatalal  K.  Sutaria,
entered into that certain Amended and Restated  Proceeds Sharing  Agreement (the
"Amended and Restated Proceeds Sharing Agreement") pursuant to which the parties
agreed to amend the terms of the  Proceeds  Sharing  Agreement  (as  defined  in
Amendment No. 3).

Pursuant to the Amended and Restated Proceeds Sharing Agreement,  the Series D-1
Holders  agreed,  severally and not jointly,  that, if, as a result of the Asset
Purchase,  the  holders of Common  Stock of the Issuer  receive  aggregate  cash
distributions  of less than  $3,000,000  and such  Series  D-1  Holder  receives
distributions  based on its  holdings  of the  Series  D-1  Preferred  Stock (as
defined in the Amendment No. 1) in excess of $6,500,000,  such Series D-1 Holder
may direct the Issuer to  distribute  or shall  itself  distribute,  such excess
amount to all  holders  of the  Common  Stock of the  Issuer on a pro rata basis
until all holders of Common Stock have received  aggregate  distributions  of at
least $3,000,000  together with any  distributions  received from the Company or
Amneal.

Pursuant to the Amended and Restated Proceeds Sharing  Agreement,  the Preferred
Holders  agreed,  severally and not jointly,  that, if, as a result of the Asset
Purchase (as defined in Amendment No. 3), each of the Series D-1 Holders receive
distributions  based on their  holdings  of the  Series D-1  Preferred  Stock in
excess of $2,000,000,  each Preferred Holder may direct the Issuer to distribute
or shall itself  distribute,  such Preferred Holder's pro rata share of $850,000
to Bhupatalal K. Sutaria; provided that to the extent that Bhupatalal K. Sutaria
receives  aggregate  distributions  from the  Company,  Amneal or the Series D-1
Holders in an amount  greater than  $250,000,  then any such excess amount shall
reduce,  dollar for dollar,  the aggregate amount payable to him pursuant to the
Amended and Restated Proceeds Sharing Agreement.

Pursuant to the Amended and Restated Proceeds Sharing  Agreement,  the Preferred
Holders  agreed,  severally and not jointly,  that, if, as a result of the Asset
Purchase,  each of the Series D-1 Holders receive  distributions  based on their
holdings  of the  Series  D-1  Preferred  Stock in  excess of  $2,000,000,  each
Preferred Holder may direct the Issuer to distribute or shall itself distribute,
such Preferred Holder's pro rata share of $350,000 to Raj Sutaria; provided that
to the  extent  that  Raj  Sutaria  receives  aggregate  distributions  from the
Company,  Amneal or the Series D-1 Holders in an amount  greater than  $200,000,
then any such excess  shall  reduce,  dollar for dollar,  the  aggregate  amount
payable to him pursuant to the Amended and Restated Proceeds Sharing  Agreement.
In the event that the Series D-1 Holders





receive  distributions  as a result of the Asset  Sale of less than  $2,400,000,
then the  amount  that the  Preferred  Holders  would  otherwise  have to pay to
Bhupatalal  K.  Sutaria  and Raj Sutaria  pursuant  to the Amended and  Restated
Proceeds Sharing  Agreement shall be reduced  (ratably as between  Bhupatalal K.
Sutaria and Raj  Sutaria)  such that each of the Series D-1 Holders will retain,
after  the  payments  to  Bhupatalal  K.  Sutaria  and  Raj  Sutaria,  at  least
$2,000,000.

The foregoing description of the First Amendment to Asset Purchase Agreement and
the Amended and  Restated  Proceeds  Sharing  Agreement is a summary only and is
qualified in its entirety by reference to the First  Amendment to Asset Purchase
Agreement  and the Amended and Restated  Proceeds  Sharing  Agreement  which are
filed as Exhibits 16 and 17 hereto,  respectively,  and  incorporated  herein by
reference.


ITEM 5. INTEREST IN SECURITIES OF THE COMPANY.

ITEM 5 OF THE SCHEDULE 13D IS HEREBY AMENDED AND RESTATED AS follows:

(a) As of the date of this Amendment No. 4, the Reporting  Persons may be deemed
to  beneficially  own 14,561,088  shares of Common Stock including (i) 2,281,914
shares of Common  Stock  issuable  to  Capital  Focus III upon  exercise  of the
Amended  and  Restated  Warrants  (as  defined in the  Amendment  No.  1);  (ii)
10,526,316  shares of Common Stock issuable to Capital Focus III upon conversion
of the Series D-1  Preferred  Stock (as defined in the  Amendment  No. 1); (iii)
877,194 shares of Common Stock issuable to Capital Focus III upon  conversion of
the  Convertible  Notes (as defined in the Amendment No. 1); (iv) 307,017 shares
of Common  Stock  issuable  to  Capital  Focus III upon  conversion  of the Note
Warrants (as defined in the Amendment  No. 1); and (v) 568,647  shares of Common
Stock  currently  owned by Capital  Focus III. The  14,561,088  shares of Common
Stock that the Reporting Persons may be deemed to beneficially own represent 18%
of the Common Stock. The percentages used in this Amendment No. 4 are calculated
based upon  66,738,422  shares of Common  Stock  outstanding  as of February 11,
2008,  which is the total number shares of Common Stock  outstanding  as of such
date as reported by the Issuer in its  Quarterly  Report on Form 10-Q filed with
the SEC on February  15,  2008.  Partners  III is  the sole  general  partner of
Capital Focus III. Neuscheler,  Tullis, Dickerson, Hohnke and Buono share voting
and/or  dispositive  power over all shares of Common Stock held by Capital Focus
III. The Reporting Persons disclaim beneficial ownership of the shares of Common
Stock  beneficially  owned  except to the  extent of their  pecuniary  interests
therein. As discussed in Item 4 of Amendment No. 1, the Reporting Persons may be
deemed to be a group with the parties to the  Irrevocable  Proxy  Agreement  (as
defined in the  Amendment  No. 1) within the meaning of Section  13(d)(3) of the
Securities and Exchange Act of 1934, however, the Reporting Persons disclaim the
creation  of a group with the parties to the  Irrevocable  Proxy  Agreement.  As
discussed in Item 4 of Amendment No. 3, the  Reporting  Persons may be deemed to
be a group with the parties to the Proceeds Sharing Agreement within the meaning
of Section  13(d)(3) of the  Securities and Exchange Act of 1934,  however,  the
Reporting  Persons  disclaim  the  creation  of a group with the  parties to the
Proceeds Sharing Agreement.

(b) Partners III is the sole general  partner of Capital Focus III.  Neuscheler,
Tullis,  Dickerson,  Hohnke and Buono share voting and/or dispositive power over
all shares.  These individuals  disclaim  beneficial  ownership of the shares of
Common Stock  beneficially  owned by the above entities  except to the extent of
their pecuniary interests therein.  The Reporting Persons disclaim their ability
to direct the voting of Issuer  shares,  other than those held  directly  by the
Reporting  Persons,  as a  result  of the  Irrevocable  Proxy  Agreement  or the
Proceeds  Sharing  Agreement  as  discussed  in Item 4 of  Amendment  No. 1. The
Reporting  Persons disclaim their ability to direct the voting of Issuer shares,
other than those held  directly  by the  Reporting  Persons,  as a result of the
Proceeds Sharing Agreement as discussed in Item 4 of Amendment No. 3.

(c) During the last sixty days there were no  transactions  in the Common  Stock
effected.  The Reporting  Persons disclaim their ability to direct the voting of
the Common Stock as a result of the Irrevocable  Proxy Agreement as discussed in
Item 4 of Amendment  No. 1. The  Reporting  Persons  disclaim  their  ability to
direct  the  voting  of the  Common  Stock as a result of the  Proceeds  Sharing
Agreement as discussed in Item 4 of Amendment No. 3.





(d) The partners or members of Capital Focus III and Partners III have the right
to participate indirectly in the receipt of dividends from, or proceeds from the
sale of,  the  shares  of  Common  Stock in  accordance  with  their  respective
ownership interests in their respective entities.

(e) Not applicable.

ITEM 6. CONTRACTS, ARRANGEMENTS, UNDERSTANDINGS OR RELATIONSHIPS WITH RESPECT TO
SECURITIES OF THE ISSUER.

As described in Item 4 above, on May 2, 2008, Interpharm Holdings,  Inc., Amneal
Pharmaceuticals  of  New  York,  LLC  and  certain  shareholders  of  Interpharm
Holdings,  Inc.  listed on the signature  pages attached  thereto entered into a
First  Amendment  to Asset  Purchase  Agreement,  a copy of which is attached as
Exhibit 16 hereto.

As described in Item 4 above,  on May 1, 2008,  Tullis-Dickerson  Capital  Focus
III, L.P, Aisling Capital II, LP, Ravis Holdings I, LLC, P&K Holdings,  LLC, Dr.
Maganlal K.  Sutaria,  Perry  Sutaria,  Raj Holdings I, LLC,  Raj Sutaria,  Ravi
Sutari and Bhupatalal K. Sutaria., entered into an Amended and Restated Proceeds
Sharing Agreement, a copy of which is attached as Exhibit 17 hereto.

ITEM 7. MATERIAL TO BE FILED AS EXHIBITS.

ITEM 7 OF THE SCHEDULE 13D IS HEREBY AMENDED TO ADD OF THE FOLLOWING:

16. First Amendment to Asset Purchase Agreement, dated May 2, 2008, by and among
Interpharm Holdings,  Inc., Amneal  Pharmaceuticals of New York, LLC and certain
shareholders of Interpharm Holdings, Inc. listed on the signature pages attached
thereto.

17. Amended and Restated Proceeds Sharing  Agreement,  dated May 1, 2008, by and
among  Tullis-Dickerson  Capital Focus III, L.P,  Aisling  Capital II, LP, Ravis
Holdings I, LLC, P&K Holdings,  LLC, Dr. Maganlal K. Sutaria, Perry Sutaria, Raj
Holdings I, LLC, Raj Sutaria, Ravi Sutari and Bhupatalal K. Sutaria.





                                   SIGNATURES

     After reasonable inquiry and to the best of his knowledge and belief,  each
of the undersigned certifies that the information set forth in this statement is
true, complete and correct.


May 6, 2008                     TULLIS-DICKERSON CAPITAL  FOCUS III, L.P.

                                BY:   TULLIS-DICKERSON PARTNERS III, L.L.C.,
                                ITS:  GENERAL PARTNER

                                By:   /s/ Joan P. Neuscheler
                                      ---------------------------------------
                                      JOAN P. NEUSCHELER
                                      Principal


May 6, 2008                           TULLIS-DICKERSON PARTNERS III, L.L.C.

                                By:   /s/ Joan P. Neuscheler
                                      ---------------------------------------
                                      JOAN P. NEUSCHELER
                                      Principal


May 6, 2008                           /s/ Joan P. Neuscheler
                                      ---------------------------------------
                                      JOAN P. NEUSCHELER

May 6, 2008                           /s/ James L.L. Tullis
                                      ---------------------------------------
                                      JAMES L.L. TULLIS

May 6, 2008                           /s/ Thomas P. Dickerson
                                      ---------------------------------------
                                      THOMAS P. DICKERSON

May 6, 2008                           /s/ Lyle A. Hohnke
                                      ---------------------------------------
                                      LYLE A. HOHNKE

May 6, 2008                           /s/ Timothy M. Buono
                                      ---------------------------------------
                                      TIMOTHY M. BUONO





                                  EXHIBIT INDEX

The Exhibit Index of the Schedule 13D is hereby amended to add the following:

16. First Amendment to Asset Purchase Agreement, dated May 2, 2008, by and among
Interpharm Holdings, Inc., Amneal Pharmaceuticals of New York, LLC and certain
shareholders of Interpharm Holdings, Inc. listed on the signature pages attached
thereto.

17. Amended and Restated Proceeds Sharing Agreement, dated May 1, 2008, by and
among Tullis-Dickerson Capital Focus III, L.P, Aisling Capital II, LP, Ravis
Holdings I, LLC, P&K Holdings, LLC, Dr. Maganlal K. Sutaria, Perry Sutaria, Raj
Holdings I, LLC, Raj Sutaria, Ravi Sutari and Bhupatalal K. Sutaria.