FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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(Print or Type Responses)

1. Name and Address of Reporting Person * Kurtz Neil M   2. Issuer Name and Ticker or Trading Symbol TorreyPines Therapeutics, Inc. [TPTX] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) __X__ Director _____ 10% Owner __X__ Officer (give title below) _____ Other (specify below) President and CEO (Last) (First) (Middle) C/O TORREYPINES THERAPEUTICS, INC., 11085 NORTH TORREY PINES ROAD, SUITE 300 3. Date of Earliest Transaction (Month/Day/Year) 12/14/2006 (Street) LA JOLLA, CA 92037 4. If Amendment, Date Original Filed(Month/Day/Year) 6. Individual or Joint/Group Filing(Check Applicable Line) _X_ Form filed by One Reporting Person ___ Form filed by More than One Reporting Person (City) (State) (Zip) Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned

1.Title of Security (Instr. 3) 2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 3)

2. Conversion or Exercise Price of Derivative Security

3. Transaction Date (Month/Day/Year)

3A. Deemed Execution Date, if any (Month/Day/Year)

4. Transaction Code (Instr. 8)

5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5)

6. Date Exercisable and Expiration Date (Month/Day/Year)

7. Title and Amount of Underlying Securities (Instr. 3 and 4)

8. Price of Derivative Security (Instr. 5)

9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)

10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)

11. Nature of Indirect Beneficial Ownership (Instr. 4)

Code

V

(A)

(D)

Date Exercisable

Expiration Date

Title

Amount or Number of Shares

stock options

$ 6.37

12/14/2006

A

65,000

(1)

12/13/2016

common stock

65,000

$ 0

65,000

D

restricted stock options

$ 0 (2)

12/14/2006

A

65,000

03/31/2009(3)

03/31/2009(4)

common stock

25,000

$ 0

65,000

D

Reporting Owners

Reporting Owner Name / Address	Relationships
	Director	10% Owner	Officer	Other
Kurtz Neil M C/O TORREYPINES THERAPEUTICS, INC. 11085 NORTH TORREY PINES ROAD, SUITE 300 LA JOLLA, CA 92037	X		President and CEO

Signatures

/s/ Agatha M. Martindale, Attorney-in-fact		12/18/2006
**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	25% of the options will become exercisable on 12/14/2007. Thereafter, equal portions of the remaining options will become exercisable on the 14th of each month, beginning on 1/14/2008 and continuing through 12/14/2010.
(2)	Each restricted stock unit represent the right to receive one share of Issuer's common stock if the stock price of the Issuer meets the thresholds described below in footnote (3). Restricted stock units are granted pursuant to the Issuer's 2006 Equity Incentive Plan.
(3)	Restricted stock unit grants would become exercisable on 3/31/09 if the average stock price (based on average daily closing price) for the 6-month period ending 3/31/09 is at or above $10.36. Additional conditions may also apply pursuant to the terms of the Reporting Person's grant and/or employment agreement.
(4)	Restricted stock unit grants will terminate on 3/31/09 if conditions are not met (see footnote 3 above). Expiration date is also subject to the terms of Reporting Person's grant agreement.

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