UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C.  20549
SCHEDULE 13D
Under the Securities Exchange Act of 1934
(Amendment No.  )


Xcyte Therapies, Inc.

(Name of Issuer)

Common Stock,
(Title of Class of Securities)

98389F309
(CUSIP Number)
		with a copy to:
Austin W. Marxe		Allen B. Levithan, Esq.
527 Madison Avenue, Suite 2600		Lowenstein Sandler PC
New York, New York  10022		65 Livingston Avenue
			Roseland, New Jersey  07068
			(973) 597-2424
(Name, Address and Telephone Number of Person 
Authorized to Receive Notices and Communications)

December 15, 2005
(Date of Event which Requires Filing of this Statement)


If the filing person has previously filed a statement on Schedule l3G to report 
the acquisition that is the subject of this Schedule 13D, and is filing this 
schedule because of section 240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check 
the following box. ?

Note:  Schedules filed in paper format shall include a signed original and five
copies of the schedule, including all exhibits.  See section 240.13d-7 for
other parties to whom copies are to be sent.

*The remainder of this cover page shall be filled out for a reporting person's 
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter 
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be
deemed to be ?filed? for the purpose of Section 18 of the Securities Exchange 
Act of 1934 (?Act?) or otherwise subject to the liabilities of that section of 
the Act but shall be subject to all other provisions of the Act (however, see 
the Notes).




Cusip No.   98389F309      	
	1.	Names of Reporting Persons.  I.R.S. Identification Nos. of above 
persons (entities only):
	
	Austin W. Marxe and David M. Greenhouse

	
	2.	Check the Appropriate Box if a Member of a Group (See Instructions):
	(a)	[    ]	 	Not Applicable
	(b)	[    ]	
	
	3.	SEC Use Only
	
	4.	Source of Funds (See Instructions):  00
	
	5.	Check if Disclosure of Legal Proceedings Is Required Pursuant to 
Items 2(d) or 2(e):
				Not Applicable
	
	6.	Citizenship or Place of Organization:	    United States
	
	Number of	7.	Sole Voting Power:	0*
	Shares Beneficially	8.	Shared Voting Power:      4,442,609*
	Owned by
	Each Reporting	9.	Sole Dispositive Power:	0*
	Person With	10.	Shared Dispositive Power:      4,442,609*
	
	11.	Aggregate Amount Beneficially Owned by Each Reporting Person:   
4,442,609*
	
	12.	Check if the Aggregate Amount in Row (11) Excludes Certain Shares
		(See Instructions):		               Not Applicable
	
	13.	Percent of Class Represented by Amount in Row (11):    22.6% *
	
	14.	Type of Reporting Person (See Instructions):       IA, IN
	

*	This is a joint filing by Austin W. Marxe (?Marxe?) and David M. 
Greenhouse (?Greenhouse?).  Marxe and Greenhouse share sole voting and 
investment power over 854,936 shares of Common Stock owned by Special 
Situations Cayman Fund, L.P., 3,199,763 shares of Common Stock owned by 
Special Situations Fund III, L.P., and 387,910 shares of Common Stock 
owned by Special Situations Life Sciences Fund, L.P.  See Items 2 and 5of 
this Schedule 13D for additional information.


Item 1.	Security and Issuer.
	This schedule related to the common stock and warrants of XCYTE 
Therapies, Inc. (the ?Issuer?). The Issuer?s principal executive officers are 
located at 1124 Columbia Street, Suite 130, Seattle, WA  98104

Item 2.	Identity and Background.
	The persons filing this report are Austin W. Marxe (?Marxe?) and 
David M. Greenhouse (?Greenhouse?), who are the controlling principals of AWM 
Investment Company, Inc. (?AWM?), the general partner of and investment adviser
to Special Situations Cayman Fund, L.P. (?Cayman?).  AWM also serves as the 
general partner of MGP Advisers Limited Partnership (?MGP?), the general partner
of and investment adviser to Special Situations Fund III, L.P. (?SSF3?).  Marxe
and Greenhouse are also members of LS Advisers L.L.C. (?LS?), the general 
partner of and investment adviser to Special Situations Life Sciences Fund,
L.P. (?LIFE?). (SSF3, Cayman, and LIFE will hereafter be referred to as, the 
?Funds?).  

The principal office and business address of the Reporting Persons, is 527 
Madison Avenue, Suite 2600, New York NY 10022.

The principal business of each Fund is to invest in equity and equity-related 
securities and other securities of any kind or nature.

	Mr. Marxe and Mr. Greenhouse have never been convicted in any 
criminal proceeding (excluding traffic violations or similar misdemeanors), nor 
have either of them been a party to any civil proceeding commenced before a 
judicial or administrative body of competent jurisdiction as a result of which 
he was or is now subject to a judgment, decree or final order enjoining future 
violations of, or prohibiting or mandating activities subject to, federal or 
state securities laws or finding any violation with respect to such laws.  Mr. 
Marxe and Mr. Greenhouse are citizens of the United States.

Item 3.	Source and Amount of Funds or Other Consideration.
	Each Fund utilized its own available net assets to purchase the 
securities referred to in this Schedule.

Item 4.	Purpose of Transaction.

	The securities referred to in this Schedule have been acquired by 
each of the Funds for investment purposes and not with the purpose or effect of
changing or influencing control of the Issuer.  Each Fund acquired the 
securities in the ordinary course of business and is holding the securities for
the benefit of its investors.

Item 5.	Interest in Securities of the Issuer.

		Cayman owns 854,936 shares of Common Stock, or 4.3% of the shares 
outstanding, SSF3 owns 3,199,763 shares of Common Stock or 16.3% of the shares 
outstanding, LIFE owns 387,910 shares of Common Stock, or 2.0% of the 
outstanding shares.  Messrs. Marxe and Greenhouse share the power to vote and 
direct the disposition of all shares of Common Stock owned by each of the
Funds. Messrs. Marxe and Greenhouse are deemed to beneficially own a total of 
4,442,609 shares of Common Stock or 22.6% of the outstanding shares.

		The following table reflects the acquisitions and dispositions by 
each of the Funds during the month of December 2005.  All other transactions 
prior to December 1, 2005 have been disclosed in a prior 13G filing. (Each of 
which were effected in ordinary broker transactions):

A.  Special Situations Cayman Fund, L.P. 

Date
Quantity
Average Price

(Purchases)


During December 2005
124,988
$0.47
	

Date
Quantity
Average Price

(Sales)








         B.  Special Situations Life Sciences Fund, L.P. 

Date
Quantity
Average Price

(Purchases)

During December 2005
353,900
$0.48


Date

Quantity

Average Price

(Sales)






C.	 Special Situations Fund III, L.P. 

Date
Quantity
Average Price


(Purchases)

During December 2005
482,360
$0.46
 

Date

Quantity

Average Price

(Sales)





Item 6.	Contracts, Arrangements, Understandings or Relationships With 
Respect to Securities of the Issuer.

		No contracts, arrangements, understandings or similar relationships 
exist with respect to the securities of the Company between Messrs. Marxe and 
Greenhouse and any other individual or entity.  

Item 7.	Material to be Filed as Exhibits.

	Joint Filing Agreement.


Signature

	After reasonable inquiry and to the best of my knowledge and belief, 
I certify that the information set forth in this statement is true, complete and
correct.


December 23,2005




	/s/_Austin W. Marxe			
Austin W. Marxe



	/s/_David M. Greenhouse		
David M. Greenhouse






Attention:  Intentional misstatements or omissions of fact constitute Federal 
criminal violations (See 18 U.S.C. 1001).


JOINT FILING AGREEMENT


	Austin W. Marxe and David M. Greenhouse hereby agree that the Schedule 
13D to which this agreement is attached is filed on behalf of each of them.



	/s/_Austin W. Marxe			
Austin W. Marxe



	/s/_David M. Greenhouse		
David M. Greenhouse





 
 
 
 


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