UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                    FORM 8-K

                                 CURRENT REPORT
     Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934

         Date of Report (Date of earliest event reported): March 8, 2006

                           Applied DNA Sciences, Inc.
             (Exact name of registrant as specified in its charter)



          Nevada                       002-90539               59-2262718
--------------------------------------------------------------------------------
(State or other jurisdiction     (Commission File Number)      (IRS Employer
     of incorporation)                                       Identification No.)


        25 Health Sciences Drive, Suite 113, Stony Brook, New York 11790
              (Address of principal executive offices and Zip Code)

        Registrant's telephone number, including area code (631) 444-6862




Check  the  appropriate  box  below  if the  Form  8-K  filing  is  intended  to
simultaneously  satisfy the filing obligation of the registrant under any of the
following provisions (see General Instruction A.2. below):

[ ] Written communications pursuant to Rule 425 under the Securities Act (17 CFR
230.425)
[ ] Soliciting  material  pursuant to Rule 14a-12 under the Exchange Act (17 CFR
240.14a-12)
[ ] Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange
Act (17 CFR 240.14d-2(b))
[ ] Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange
Act (17 CFR 240.13e-4(c))




Item 1.01 Entry into a Material Definitive Agreement.
Item 2.03 Creation of a Direct Financial Obligation.
Item 3.02 Unregistered Sales of Equity Securities.

     On March 8, 2006,  we  completed a private  placement  offering in which we
sold an  aggregate  of 30 units  (the  "Units")  of our  securities,  each  Unit
consisting of (i) a $50,000 Principal Amount 10% Secured Convertible  Promissory
Note (the "Notes") and (ii) warrants (the "Warrants") to purchase 100,000 shares
of our common stock, or an aggregate of $1,500,000 in principal  amount of Notes
and Warrants to purchase  3,000,000  shares of common stock, for aggregate gross
proceeds of $1,500,000. The Units were sold pursuant to Subscription Agreements,
by and between each of the  purchasers  and Applied DNA  Operations  Management,
Inc., our wholly owned subsidiary.

     The Notes bear  interest  at the rate of 10% per annum and mature 18 months
after the date of  issuance.  The  Notes,  and  interest  accrued  thereon,  are
convertible into shares of our common stock at a price of $0.50 per share by the
holder  anytime from issuance  through the first  anniversary of issuance of the
Notes and  automatically  convert on the maturity  date at a 20% discount to the
average  bid  price  for our  common  stock for the ten  trading  days  prior to
conversion. In addition, the holders have the right anytime after the 15th month
and through  the 18th month  after the date of  issuance  to request  payment of
accrued interest and principal in cash and, anytime prior to conversion, we have
the irrevocable right to repay accrued interest and principal under the Notes on
3 days  notice,  subject to the  holders'  voluntary  right to convert the Notes
during such three day period. All principal and accrued interest under the Notes
will be due and payable in the event that we  consolidate  or merge with another
entity,  unless (i) we shall be the surviving  entity in such  consolidation  or
merger,  or (ii) the other entity  controls,  is under common control with or is
controlled by us immediately prior to the consolidation or merger whether or not
we shall be the surviving entity in such consolidation or merger, in which event
the Notes shall remain  outstanding  as an  obligation  of the  consolidated  or
surviving  entity.  Upon an event of default under the Notes,  all principal and
accrued  but  unpaid  interest  under the Notes  will  automatically  be due and
payable,  and the Notes shall bear interest  until repaid at a default  interest
rate of 12%.  The Notes are  secured by all of our  assets,  including,  but not
limited to, our patents, trademarks, equipment, fixtures, inventory and accounts
receivable,  for the benefit of the holders, subject to our right to issue up to
an additional  $11,500,000 in principal  amount of indebtedness  with a security
interest  in our assets  which is pari passu with the  security  interest of the
holders of the Notes.

     The  Warrants are  exercisable  from March 8, 2006 until March 7, 2011 at a
price of $0.50 per share,  subject to adjustment in certain  events,  including,
without  limitation,   upon  our  consolidation,   merger  or  sale  of  all  of
substantially all of our assets, a reclassification  of our common stock, or any
stock splits,  combinations  or dividends with respect to our common stock.  The
Warrants  are callable at a price equal to $1.25 per share on the earlier of (i)
one year from issuance or (ii) the date that the shares of common stock issuable
upon exercise of the Warrants are registered for resale and our common stock has
traded at or above $1.25 per share for 20 consecutive trading days.

     In addition,  we have agreed to file a registration  statement on Form SB-2
to effect the  registration  of 100% of our shares of common stock issuable upon
conversion  of the  Notes and  exercise  of the  Warrants  within 30 days of the
effective  date of our  pending  registration  statement  on Form SB-2 (SEC File
333-122848)  being  declared  effective  by the SEC.  We have  agreed to use our
reasonable  best  efforts to cause the  registration  statement  to be  declared
effective  no later than 180 days after the  filing  date.  If we fail to file a
registration  statement with the SEC on or before the time frame described,  the
holders  will be entitled to  liquidated  damages  from  Applied DNA  Operations
Management,  Inc. in an amount  equal to 2% per month for each month that we are
delinquent in filing the registration statement.

     Arjent  Limited,  a registered  broker dealer firm,  (the "Selling  Agent")
acted as our selling agent in connection with the Offering.  We paid the Selling
Agent:  (a) a  commission  equal to $180,000,  representing  12% of the Offering
proceeds;  (b) a 3% non-accountable  expense allowance in the amount of $45,000;
(c) $75,000 for the Selling Agent's legal fees; (d) shares of common stock equal
to 10% of the number of shares issuable upon conversion of the Notes on the date
of issuance of the Notes;  and (e) $90,000 for consulting  and management  fees,
which  will be paid to  Vertical  Capital  Partners  under the  Selling  Agent's
exclusive  banking  agreement with Vertical Capital  Partners.  In addition,  we
issued  2,000,000 shares of common stock to the Selling Agent in its capacity as
our investment  banker.  The Selling Agent had no obligation to buy any Notes or
Warrants  from us. In  addition,  we agreed to indemnify  the Selling  Agent and
other persons against specific  liabilities under the Securities Act of 1933, as
amended (the "Act").

     We claim an exemption from the registration requirements of the Act for the
private  placement of these  securities  pursuant to  Regulation  S  promulgated
thereunder  since,  among other things,  the investors were offshore  accredited
investors.

                                       2




Item 9.01 Financial Statements and Exhibits.

(a)      Financial statements of business acquired.

         Not applicable.

(b)      Pro forma financial information.

         Not applicable.

(c)      Exhibits.

Exhibit
Number                    Description
------- ------------------------------------------------------------------------
10.1    Form of  Subscription  Agreement  by and among  Applied  DNA  Operations
        Management, Inc. and the investors named on the signature pages thereto.

10.2    Form of 10% Secured Convertible Promissory Note of Applied DNA Sciences,
        Inc.

10.3    Form of Warrant  Agreement  of Applied DNA  Sciences,  Inc.



                                       3

                                   SIGNATURES

     Pursuant to the  requirements  of the Securities  Exchange Act of 1934, the
registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned hereunto duly authorized.

                                              Applied DNA Sciences, Inc.


Date: March 14, 2006                         /s/ JAMES HAYWARD
                                             ------------------
                                             James Hayward
                                             Chief Executive Officer



                                        4