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If delivery of the Prospectus is expected to be made pursuant to Rule 434, please check the following box. o

 

CALCULATION OF REGISTRATION FEE

Title of Each Class of Securities to be Registered		Amount to be Registered			Proposed Offering Price Per Share			Proposed Aggregate Offering Price			Amount Of Registration Fee
Common Stock			8,088,667		$	1.00	(1)	$	8,088,667		$	865.49
Common Stock—Penalty(9)			50,000		$	1.00	(1)	$	50,000		$	5.35
Common Stock underlying class “A” warrant			2,508,333		$	1.50	(2)(3)	$	3,762,500		$	402.59
Common Stock underlying class “A” warrants—Penalty(10)			25,000		$	1.50	(2)(10)	$	37,500		$	4.01
Common Stock underlying class “B” warrant			2,508,333		$	2.00	(2)(4)	$	5,016,667		$	536.78
Common Stock underlying class “B” warrants—Penalty(11)			25,000		$	2.00	(2)(10)	$	50,000		$	5.35
Common Stock underlying $.50 warrants issued to service providers			1,330,000		$	.50	(2)(5)	$	665,000		$	71.16
Common Stock underlying $5.00 warrant			1,000,000		$	5.00	(2)(6)	$	5,000,000		$	535.00
Common Stock underlying Placement Agent Warrant			800,000		$	1.10	(2)(7)	$	880,000		$	94.16
Total			16,335,333					$	23,550,334		$	2,519.89	(8)

 

(1)

Estimated solely for the purpose of calculating the registration fee in accordance with Rule 457 of the Securities Act based upon a per share amount of $1.00, based on the price on which the securities were previously sold pursuant to the Company's March 2006 private placements. There is currently no trading market for the Registrant's common stock. The price of $1.00 is a fixed price at which the selling stockholders identified herein may sell their shares until the Registrant's common stock is quoted on the OTC Bulletin Board, at which time the shares may be sold at prevailing market prices or privately negotiated prices.

(2)	Fee based on exercise price applicable to shares issuable upon exercise of warrants in accordance with Rule 457(g).

(3)	Represents shares of Common Stock issuable upon the exercise (at a price of $1.50 per share) of outstanding warrants.

(4)	Represents shares of Common Stock issuable upon the exercise (at a price of $2.00 per share) of outstanding warrants.

(5)	Represents shares of Common Stock issuable upon the exercise (at a price of $.50 per share) of outstanding warrants.

(6)	Represents shares of Common Stock issuable upon the exercise (at a price of $5.00 per share) of outstanding warrants.

(7)	Represents shares of Common Stock issuable upon the exercise (at a price of $1.10 per share) of outstanding warrants.

(8)	Registrant previously paid $2,505.18 in connection with its filings.

 

(9)	Represents shares of Common Stock issuable as penalties arising from certain registration rights.

(10)	Represents shares of Common Stock issuable upon the exercise (at a price of $1.50) of warrants that may become outstanding as a result of penalties arising from certain registration rights.

(11)	Represents shares of Common Stock issuable upon the exercise (at a price of $2.00) of warrants that may become outstanding as a result of penalties arising from certain registration rights.

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The information in this Prospectus is not complete and may be changed. We have filed a registration statement containing this prospectus with the Securities and Exchange Commission.  The securities offered for sale under this prospectus may not be offered for sale or sold until the registration statement filed with the Securities and Exchange Commission is effective.  This Prospectus is not an offer to sell these securities and it is not soliciting an offer to buy these securities in any state where the offer or sale is not permitted.

OFFERING PROSPECTUS

Subject to completion, dated August 25, 2006

NEURALSTEM, INC.

A DELAWARE CORPORATION

16,335,333

Common Shares

The selling stockholders identified on pages 35− 45 this prospectus are offering on a resale basis a total of 16,335,333 shares of our common stock. We will not receive any proceeds from the sale of these shares by the selling stockholders.

Our common stock is not presently traded on any market or securities exchange, and we have not applied for listing or quotation on any public market. We anticipate seeking sponsorship for the trading of our common stock on the National Association of Securities Dealers OTC Bulletin Board upon the effectiveness of the registration statement of which this prospectus forms a part. However, we can provide no assurance that our shares will be traded on the OTC Bulletin Board or, if traded, that a public market will materialize. The selling shareholders will sell at a price of $1.00 per share until our shares are quoted on the OTC Bulletin Board and thereafter at prevailing market prices or privately negotiated prices.

_________________________________

The securities offered by this prospectus involve a high degree of risk.

See “Risk Factors” beginning on page 6

 _________________________________

Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved

these securities or determined that this prospectus is truthful or complete. A representation to the contrary is a criminal

offense.

 

The date of this Prospectus is August 25, 2006

 

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TABLE OF CONTENTS

 

RISK FACTORS	6
FORWARD LOOKING STATEMENTS	12
USE OF PROCEEDS	13
OUR BUSINESS	13
Our History	13
Overview	13
The Field of Regenerative Medicine	14
Stem Cell Therapy Background	14
The Potential of Our Tissue-Derived Stem Cell-Based Therapy	14
Potential Markets	15
Our Technology	15
Business Strategy	15
Our Research and Programs	16
Our Grant	17
Our Intellectual Property Licensed to Others	17
Manufacturing	18
Products & Marketing	18
Our Intellectual Property	18
Patents Pending	19
Patents Issued	19
Competition	20
Government Regulation	21
Employees	22
PROPERTIES	22
MANAGEMENT'S DISCUSSION AND ANALYSIS	23
RESULTS OF OPERATIONS	25
LEGAL PROCEEDINGS	28
MANAGEMENT	28
Audit Committee Financial Expert	28
Code of Ethics	28
EXECUTIVE COMPENSATION	29
Summary Compensation Table	29
Option Grants in Last Fiscal Year	29
Compensation of Directors	30
Employment Agreements and Change-in-Control Arrangements	30
PRINCIPAL STOCKHOLDERS	30
TRANSACTIONS AND BUSINESS RELATIONSHIPS WITH	32
DESCRIPTION OF SECURITIES	32
General	32
Common Stock	32
Preferred Stock	33
Options And Warrants Convertible into Common Shares	33
EQUITY COMPENSATION PLAN INFORMATION	33
2005 Stock Plan	33
MARKET FOR COMMON EQUITY & RELATED STOCKHOLDER MATTERS	33
Market Information	33
Dividend Policy	34
SHARES ELIGIBLE FOR FUTURE SALE	34
SELLING SHAREHOLDERS	35

 

 

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REGISTRATION RIGHTS	45
PLAN OF DISTRIBUTION	46
TRANSFER AGENT	48
LEGAL MATTERS	48
EXPERTS	48
INDEMNIFICATION OF DIRECTORS AND OFFICERS	48
WHERE YOU CAN FIND MORE INFORMATION	48
FINANCIAL INFORMATION	F-1
INFORMATION NOT REQUIRED IN PROSPECTUS	II-1
Indemnification Of Directors & Officers	II-1
Other Expenses of Issuance & Distribution	II-1
Recent Sales of Unregistered Securities	II-1
Exhibits	II-4

 

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RISK FACTORS

An investment in Neuralstem, Inc. involves significant risks. You should read these risk factors carefully before deciding whether to invest in our company. The following is a description of what we consider our key challenges and risks.

 

Risks Relating to the Company's Stage of Development

Since the Company has a limited operating history and has significantly shifted its operations and strategies since inception, you cannot rely upon the Company's limited historical performance to make an investment decision. 

 

Since inception in 1996 and through December 31, 2005, the Company has raised an aggregate of slightly in excess of approximately $34,901,568 in capital and recorded accumulated losses totaling $35,445,238 of December 31, 2005, the Company had a working capital deficit of $475,243 and negative stockholder's equity of $460,173. Our net losses for the two most recent fiscal years have been $1,651,507 and $9,376,543 for 2005 and 2004 respectively. During this period, we have generated only marginal revenue from licensing and grants in the amount of $125,457 and $309,142 for the 2004 and 2005 fiscal years, respectively.

 

The Company's ability to generate revenues and achieve profitability depends upon its ability to complete the development of its stem cell products, obtain the required regulatory approvals and manufacture, market and sell its products. In part because of the Company's past operating results, no assurances can be given that the Company will be able to accomplish all or any these goals.

Although the Company has generated some revenue to date, the Company has not generated any revenue from the commercial sale of its proposed stem cell products. Since inception, the Company has engaged in several related lines of business and has discontinued operations in certain areas. For example, in 2002, the Company lost a material contract with the Department of Defense and was forced to close its principal facility and lay off almost all of its employees in an attempt to focus the Company's strategy on its stem cell technology. This limited and changing history may not be adequate to enable you to fully assess the Company's current ability to develop and commercialize its technologies and proposed products, obtain approval from the U.S. Food and Drug Administration (“FDA”), achieve market acceptance of its proposed products and respond to competition. No assurances can be given as to exactly when, if at all, the Company will be able to fully develop, commercialize, market, sell and derive material revenues from its proposed products in development.

The Company will need to raise additional capital to continue operations, and failure to do so would impair the Company's ability to fund operations, develop its technologies or promote its products. 

The Company has relied almost entirely on external financing to fund operations. Such financing has historically come primarily from the sale of common and preferred stock and convertible debt to third parties and to a lesser degree from grants, loans and revenue from license and royalty fees. The Company anticipates, based on current proposed plans and assumptions relating to its operations (including the timetable of, and costs associated with, new product development) and financing the Company has undertaken prior to the date of this prospectus, that its current working capital will be sufficient to satisfy contemplated cash requirements for approximately 11 months, assuming that the Company does not engage in an extraordinary transaction or otherwise face unexpected events or contingencies, any of which could effect cash requirements. As of June 30, 2006, the Company has cash and cash equivalents on hand of $3,202,703. Presently, the Company has a monthly cash burn rate of $260,000. Accordingly, the Company will need to raise additional capital to fund anticipated operating expenses and future expansion after such 11 month period. Among other things, external financing will be required to cover the further development of the Company's technologies and products and other operating costs. The Company cannot assure you that financing whether from external sources or related parties will be available if needed or on favorable terms. If additional financing is not available when required or is not available on acceptable terms, the Company may be unable to fund operations and planned growth, develop or enhance its technologies, take advantage of business opportunities or respond to competitive market pressures. Any negative impact on the Company's operations may make capital raising more difficult and may also result in a lower price for the Company's securities.

The Company may have difficulty raising needed capital in the future as a result of, among other factors, the Company's limited operating history and business risks associated with the Company.

The Company's business currently generates limited amounts of cash which will not be sufficient to meet its future capital requirements. The Company's management does not know when this will change. The Company has expended and will continue to expend substantial funds in the research, development and clinical and pre-clinical testing of the Company's stem cell technologies and products. The Company will require additional funds to conduct research and development, establish and conduct clinical and pre-clinical trials, commercial-scale manufacturing arrangements and to provide for the marketing and distribution. Additional funds may not be available on acceptable terms, if at all. If adequate funds are unavailable from any available source, the Company may have to delay, reduce the scope of or eliminate one or more of its research, development or commercialization programs or product launches or marketing efforts which may materially harm the Company's business, financial condition and results of operations.

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The Company's long term capital requirements are expected to depend on many factors, including:

 

·	continued progress and cost of its research and development programs;

 

·	progress with pre-clinical studies and clinical trials;

 

·	time and costs involved in obtaining regulatory clearance;

 

·	costs involved in preparing, filing, prosecuting, maintaining and enforcing patent claims;

 

·	costs of developing sales, marketing and distribution channels and its ability to sell the Company's stem cell products;

 

·	costs involved in establishing manufacturing capabilities for commercial quantities of its products;

 

·	competing technological and market developments;

 

·	market acceptance of its stem cell products;

 

·	costs for recruiting and retaining employees and consultants; and

 

·	costs for educating and training physicians about its stem cell products.

 

The Company may consume available resources more rapidly than currently anticipated, resulting in the need for additional funding. The Company may seek to raise any necessary additional funds through the exercising of warrants, options, equity or debt financings, collaborative arrangements with corporate partners or other sources, which may be dilutive to existing stockholders or otherwise have a material effect on the Company's current or future business prospects. If adequate funds are not available, the Company may be required to significantly reduce or refocus its development and commercialization efforts.

The Company relies on stem cell technologies that it may not be able to commercially develop, which will prevent the Company from generating revenues, operating profitably or providing investors any return on their investment. 

 

The Company has concentrated its research on its stem cell technologies, and the Company's ability to generate revenue and operate profitably will depend on it being able to develop these technologies for human applications. These are emerging technologies with, as yet, limited human applications. The Company cannot guarantee that it will be able to develop its stem cell technologies or that such development will result in products or services with any significant commercial utility. The Company anticipates that the commercial sale of such products or services, and royalty/licensing fees related to its technology, will be the Company's primary sources of revenues. If the Company is unable to develop its technologies, investors will likely lose their entire investment.

 

Inability to complete pre-clinical and clinical testing and trials will impair the viability of the Company. 

 

 

The Company's additional financing requirements could result in dilution to existing stockholders.

The additional financings which the Company will require may in the future be obtained through one or more transactions which will effectively dilute the ownership interests of stockholders. The Company has the authority to issue additional shares of common stock and preferred stock, as well as additional classes or series of ownership interests or debt obligations which may be convertible into any one or more classes or series of ownership interests. The Company is authorized to issue 75 million shares of common stock and 7 million shares of preferred stock. Such securities may be issued without the approval or other consent of the Company's stockholders.

 

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Risks Relating to Intellectual Property and Government Regulation

 

The Company may not be able to withstand challenges to its intellectual property rights, such as patents, should contests be initiated in court or at the U.S Patent and Trademark Office.

 

The Company relies on its intellectual property, including its issued and applied for patents, as the foundation of its business. The intellectual property rights of the Company may come under challenge, and no assurances can be given that, even though issued, the Company's current and potential future patents will survive claims commencing in the court system alleging invalidity or infringement on other patents. For example, in 2005, the Company's neural stem cell technology was challenged in the U.S. Patent and Trademark Office by a competitor. Although the Company prevailed in this particular matter upon re-examination by the patent office, these cases are complex, lengthy and expensive, and could potentially be adjudicated adversely to the Company, removing the protection afforded by an issued patent. The viability of the Company's business would suffer if such patent protection were limited or eliminated. Moreover, the costs associated with defending or settling intellectual property claims would likely have a material adverse effect on the Company.

 

The Company may not be able to adequately protect against piracy of intellectual property in foreign jurisdictions. 

 

Considerable research in the area of stem cell therapies is being performed in countries outside of the United States, and a number of the Company's competitors are located in those countries.  The laws protecting intellectual property in some of those countries may not provide protection for the Company's trade secrets and intellectual property adequate to prevent its competitors from misappropriating the Company's trade secrets or intellectual property.  If the Company's trade secrets or intellectual property are misappropriated in those countries, the Company may be without adequate remedies to address the issue.

The Company has entered into long-term contracts with key personnel and stockholders, with significant anti-termination provisions, which could make future changes in management difficult or expensive. 

Messrs. Garr and Johe have entered into seven (7) year employment agreements with the Company which expire on November 1, 2012 and which include termination provisions stating that if either employee is terminated for any reason other than a voluntary resignation, then all compensation due to such employee under the terms of the respective agreement shall become due and payable immediately. These provisions will make the replacement of either of these employees very costly to the Company, and could cause difficulty in effecting a change in control of the Company. Termination prior to full term on the contracts would cost the Company $240,000 per year unserved, or as much as $1,680,000 per contract, and immediate vesting of all outstanding options (1,200,000 shares each). Further, three of the Company's existing shareholders (Westreich, Solomon and Drescher, collectively owning approximately 36% of the outstanding shares of Common Stock), have entered into a voting agreement such that so long as Messrs. Garr and Johe are stockholders, these 3 owners will vote their shares for the election of Garr and Johe as directors of the Company. This voting agreement gives more control to Johe and Garr than their respective stockholdings alone would provide, and will also make future changes in control more difficult without their approval. For further information relating to these agreements, see that section of this prospectus captioned “Executive Compensation--Employment Agreements and Change in Control Arrangements”.

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The Company has no product liability insurance, which may leave it vulnerable to future claims that the Company will be unable to satisfy. 

The testing, manufacturing, marketing and sale of human therapeutic products entails an inherent risk of product liability claims, and the Company cannot assure you that substantial product liability claims will not be asserted against it. The Company has no product liability insurance. In the event the Company is forced to expend significant funds on defending product liability actions, and in the event those funds come from operating capital, the Company will be required to reduce its business activities, which could lead to significant losses.

The Company cannot assure you that adequate insurance coverage will be available in the future on acceptable terms, if at all, or that, if available, the Company will be able to maintain any such insurance at sufficient levels of coverage or that any such insurance will provide adequate protection against potential liabilities. 

The Company will have limited director and officer insurance and commercial insurance policies. Any significant insurance claims would have a material adverse effect on its business, financial condition and results of operations. Insurance availability, coverage terms and pricing continue to vary with market conditions. The Company endeavors to obtain appropriate insurance coverage for insurable risks that it identifies, however, the Company may fail to correctly anticipate or quantify insurable risks, may not be able to obtain appropriate insurance coverage, and insurers may not respond as the Company intends to cover insurable events that may occur. The Company has observed rapidly changing conditions in the insurance markets relating to nearly all areas of traditional corporate insurance. Such conditions have resulted in higher premium costs, higher policy deductibles, and lower coverage limits. For some risks, the Company may not have or maintain insurance coverage because of cost or availability.

 

Risks Relating to the Company's Common Stock

 

There is no public market for the Company's securities and no assurances can be given that one will ever develop.

The Company is a private company. Without registration, there is only a limited ability of a security holder to sell their securities, as those transfers or sales would be made privately. Therefore, an investment in our common stock should be considered as totally illiquid, and investors are cautioned that may not be able to liquidate their investment readily or at all when the need or desire to sell arises. Moreover, no assurances can be given that a public market for our securities will ever materialize. Additionally, even if a public market for our securities develops and our securities become listed, the trading volume may be limited, making it difficult for an investor to sell shares.

 

The Company has identified significant weaknesses with regard to its financial control procedures.   These weaknesses, if not remedied, could result in a significant misstatement of the Company's financials or its inability to provide timely disclosure to the public should it become subject to such reporting requirements.

As a result of its stage of development, lack of resources and changes that have occurred in the Company's operations since 2002, there are currently deficiencies in the operating effectiveness of the Company's internal controls over financial reporting that the Company believes would collectively constitute significant deficiencies and material weaknesses under standards established by the American Institute of Certified Public Accountants, resulting in more than a remote likelihood that a material misstatement of the annual or interim financial statements of the Company will not be prevented or detected. Specifically, the Company has found deficiencies or weaknesses with the timely reporting of transactions and the documentation thereof. By way of example, in the past, the company has failed to document capital transactions when they occur, has failed to establish controls for document retention, and has failed to account for transactions using GAAP. As of the date of this prospectus, the Company does not have a permanent Chief Financial Officer, although Richard Garr, the Company's President, is temporarily serving in this capacity. As a result, there is a risk that the Company may not be able to properly account for operations and/or generate reliable financial statements. This may further result in the Company not being able to meet its periodic filing requirements in a timely manner.

When and if the Company becomes a public company, the Company faces risks related to compliance with corporate governance laws and financial reporting standards. 

The Sarbanes-Oxley Act of 2002, as well as related new rules and regulations implemented by the Securities and Exchange Commission and the Public Company Accounting Oversight Board, require changes in the corporate governance practices and financial reporting standards for public companies. These new laws, rules and regulations, including compliance with Section 404 of the Sarbanes-Oxley Act of 2002 relating to internal control over financial reporting (“Section 404”), will materially increase the Company's legal and financial compliance costs and made some activities more time-consuming and more burdensome. Starting in 2007, Section 404 of the Sarbanes-Oxley Act of 2002 will require that the Company's management assess the Company's internal control over financial reporting annually and include a report on its assessment in its annual report filed with the SEC. The Company's independent registered public accounting firm is required to audit both the design and operating effectiveness of its internal controls and management's assessment of the design and the operating effectiveness of its internal controls. There exist material weaknesses and deficiencies at this time in the Company's internal controls. These weaknesses and deficiencies could have a material adverse effect on the Company's business and operations.

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The Company does not intend to pay cash dividends on its common stock in the foreseeable future.

Any payment of cash dividends will depend upon the Company's financial condition, results of operations, capital requirements and other factors and will be at the discretion of the Board of Directors. The Company does not anticipate paying cash dividends on its common stock in the foreseeable future. Furthermore, the Company may incur additional indebtedness that may severely restrict or prohibit the payment of dividends.

Our issuance of additional common shares or preferred shares, or options or warrants to purchase those shares, could dilute your proportionate ownership and voting rights and negatively impact the value of your investment in our common shares as the result of preferential voting rights or veto powers, dividend rights, disproportionate rights to appoint directors to our board, conversion rights, redemption rights and liquidation provisions granted to the preferred shareholders, including the grant of rights that could discourage or prevent the distribution of dividends to you, or prevent the sale of our assets or a potential takeover of our company.

 

We are entitled under our certificate of incorporation to issue up to 75,000,000 common and 7,000,000 “blank check” preferred shares. As of August 25, 2006, we have issued an outstanding 25,820,939 common shares, 11,121,667 common shares reserved for issuance upon the exercise of current outstanding options and warrants, and an aggregate of 100,000 common shares reserved for issuance in the event we incur additional penalties pursuant to the registration rights granted our investors in the March 2006 private placement. Accordingly, we will be entitled to issue up to 37,957,395 additional common shares and 7,000,000 additional preferred shares. Our board may generally issue those common and preferred shares, or options or warrants to purchase those shares, without further approval by our shareholders based upon such factors as our board of directors may deem relevant at that time. Any preferred shares we may issue shall have such rights, preferences, privileges and restrictions as may be designated from time-to-time by our board, including preferential dividend rights, voting rights, conversion rights, redemption rights and liquidation provisions. It is likely that we will be required to issue a large amount of additional securities to raise capital to further our development and marketing plans. It is also likely that we will be required to issue a large amount of additional securities to directors, officers, employees and consultants as compensatory grants in connection with their services, both in the form of stand-alone grants or under our various stock plans. We cannot give you any assurance that we will not issue additional common or preferred shares, or options or warrants to purchase those shares, under circumstances we may deem appropriate at the time.

 

Messers Garr, Johe, Solomon and Westreich currently beneficially own approximately 40% of our outstanding common shares. These shareholders will retain the ability to substantially control our management and the outcome of corporate actions requiring shareholder approval notwithstanding the overall opposition of our other shareholders. This concentration of ownership could discourage or prevent a potential takeover of our company that might otherwise result in you receiving a premium over the market price for your common shares.

Messers Garr, Johe, Solomon and Westreich own approximately 40% of our outstanding common shares. As a consequence of their level of stock ownership, the group will substantially retain the ability to elect a majority of our board of directors, and thereby control our management. This group of shareholders has the ability to significantly control the outcome of corporate actions requiring shareholder approval, including mergers and other changes of corporate control, going private transactions, and other extraordinary transactions. See “Principal Stockholders”.

 

FORWARD LOOKING STATEMENTS

In this prospectus we make a number of statements, referred to as “forward-looking statements”, which are intended to convey our expectations or predictions regarding the occurrence of possible future events or the existence of trends and factors that may impact our future plans and operating results. These forward-looking statements are derived, in part, from various assumptions and analyses we have made in the context of our current business plan and information currently available to use and in light of our experience and perceptions of historical trends, current conditions and expected future developments and other factors we believe are appropriate in the circumstances. You can generally identify forward looking statements through words and phrases such as“believe”, “expect”, “seek”, “estimate”, “anticipate”, “intend”, “plan”, “budget”, “project”, “may likely result”, “may be”, “may continue” and other similar expressions. When reading any forward-looking statement you should remain mindful that actual results or developments may vary substantially from those expected as expressed in or implied by that statement for a number of reasons or factors, including but not limited to:

 

·	the success of our research and development activities, the development of a viable commercial production model, and the speed with which regulatory authorizations and product launches may be achieved;

 

·	whether or not a market for our product develops and, if a market develops, the rate at which it develops;

 

·	our ability to successfully sell our products if a market develops;

 

·	our ability to attract and retain qualified personnel to implement our growth strategies;

 

·	our ability to develop sales marketing and distribution capabilities;

 

·	our ability to obtain reimbursement from third party payers for the products that we sell;

 

·	the accuracy of our estimates and projections;

 

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·	our ability to fund our short-term and long-term financing needs;

 

·	changes in our business plan and corporate strategies; and

 

·	other risks and uncertainties discussed in greater detail in the section captioned “Risk Factors”

 

Each forward-looking statement should be read in context with and in understanding of the various other disclosures concerning our company and our business made elsewhere in this prospectus. You should not place undue reliance on any forward-looking statement as a prediction of actual results or developments. We are not obligated to update or revise any forward-looking statements contained in this prospectus to reflect new events or circumstances unless and to the extent required by applicable law. 

 

USE OF PROCEEDS

 

The proceeds from the sale of the common shares to be sold under this prospectus will be retained by the selling shareholders, and will not be paid or remitted or otherwise made available to our company. Should any selling shareholder acquire the shares to be sold by exercising common share purchase warrants, or options we would receive the proceeds from the exercise price. In such an event we anticipate we would use the proceeds of such exercise for working capital and general corporate purposes.

 

OUR BUSINESS

We are a biotechnology company focused on developing and commercializing human neural stem cell technology in the emerging field of regenerative medicine.

Our History

We were incorporated in 1997 in the state of Maryland and re-incorporated in the state of Delaware in 2001. From 1997 until 2003, our research focused on: Genomics, which is the study of genes and their functions; Drug Discovery, which consists of the identification of molecules with desired biological effects that have promise as new therapeutic drugs; and Cell Therapy, which consists of treatments in which cells are administered to patients in order to repair damaged or depleted tissues.

In 2001, we were paid a licensing fee of $7.5 million by Gene Logic, Inc., payable over three years, to create a database using our technology. Also, in 2001, the Company received a Defense Department contract to do drug screening using the cells derived from its technology in the amount of $2.5 million over 18 months. Finally, during this period, we pursued our own research into transplanting cells derived from our technology to cure disease. We reached a high of roughly 50 employees in early 2000, mostly involved in the infrastructure involved with the Gene Logic/genomics and drug discovery programs.

In late 2000 and early 2001, as a result of the decline in biotech funding markets and the accompanying devaluation of the genomics industry, our genomics program was no longer commercially viable. Additionally, in late 2002, the Department of Defense cancelled the program which funded our drug discover efforts. As a result, by the end of 2003, the Company made the strategic decision to lay off its employees involved in the genomic and drug discovery programs and focus entirely on transplantation of its neural stem cells to treat diseases in patients.

The Company spent 2004 restructuring its capitalization and creating an “outsourced” model of product development by having the research conducted at various universities and research labs and having all other functions outsourced. In November of 2004 we completed a ten-for-three reverse stock split.

In 2005, the Company continued to operate under this model, with all accounting, legal, facility, manufacturing, transplantation experimentation and regulatory functions outsourced, under the supervision of Richard Garr, the Company’s President and Chief Executive Officer, and Dr. Johe, the Company’s Chairman and Chief Scientific Officer.

Overview

In 2004, we refocused our research efforts to concentrate primarily in the field of Cell Therapy. Specifically, we are focused on the development and commercialization of treatments based on transplanting human neural stem cells.

We have developed and maintain a portfolio of patents and patent applications that form the proprietary base for our research and development efforts in the area of neural stem cell research, and have ownership or exclusive licensing of four issued patents and 12 patent pending applications in the field of regenerative medicine and related technologies. We believe our technology base, in combination with our know-how, and collaborative projects with major research institutions provides a competitive advantage and will facilitate the successful development and commercialization of products for use in treatment of a wide array of neurodegenerative conditions and in regenerative repair of acute disease.

This is a young and emerging field. There can be no assurances that our intellectual property portfolio will ultimately produce viable commercialized products and processes. Even if we are able to produce a commercially viable product, there are strong competitors in this field and our product may not be able to successfully compete against them.

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All of our research efforts to date are at the level of basic research or in the pre-clinical stage of development. We are focused on leveraging our key assets, including our intellectual property, our scientific team, our facilities and our capital, to accelerate the advancement of our stem cell technologies. In addition, we are pursuing strategic collaborations with members of academia. We are currently headquartered in Rockville, Maryland.

The Field of Regenerative Medicine

    

The emerging field of treatment called "regenerative medicine" or "cell therapy" refers to treatments that are founded on the concept of producing new cells to replace malfunctioning or dead cells as a vehicle to treat disease and injury. Many significant and currently untreatable human diseases arise from the loss or malfunction of specific cell types in the body. Our focus is the development of effective methods to generate replacement cells from neural stem cells. We believe that replacing damaged or malfunctioning or dead neural cells with fully functional ones may be a useful therapeutic strategy in treating many diseases and conditions of the central nervous system (CNS) including: Alzheimer's disease, Parkinson's disease, Multiple Sclerosis, Amyotrophic Lateral Sclerosis (ALS, or Lou Gehrig's Disease), depression, and injuries to the spinal cord.

 

Stem Cell Therapy Background

 

Cells maintain normal physiological function in healthy individuals by secreting or metabolizing substances, such as sugars, amino acids, neurotransmitters and hormones, which are essential to life. When cells are damaged or destroyed, they no longer produce, metabolize or accurately regulate those substances. Cell loss or impaired cellular functions are leading causes of degenerative diseases, and some of the specific substances or proteins that are deficient in some of these diseases have been identified. Although administering these substances or proteins has some advantages over traditional pharmaceuticals, such as specificity, there is no existing technology that can deliver them precisely to the sites of action, under the appropriate physiological regulation, in the appropriate quantity, nor for the duration required to cure the degenerative condition. Cells, however, may do all this naturally. Thus, where failing cells are no longer producing needed substances or proteins or where there has been irreversible tissue damage or organ failure, transplantation of stem or progenitor cells may enable the generation of new functional cells, thus potentially restoring organ function and the patient's health.

Stem cells have two defining characteristics: (i) they produce all the kinds of mature cells making up the particular organ; and (ii) they self renew -- that is, some of the cells developed from stem cells are themselves new stem cells, thus permitting the process to continue again and again. Stem cells are known to exist for a number of systems of the human body, including the blood and immune system, the central and peripheral nervous systems (including the brain), the skin, bone, and even hair. They are thought to exist for many others, including the liver and pancreas endocrine systems, gut, muscle, and heart. Stem cells are responsible for organ regeneration during normal cell replacement and, to a greater or lesser extent, after injury.

 

Stem cells are rare and only available in limited supply, whether from the patients themselves or from donors. Also, cells can often be obtained only through significant surgical procedures. Therefore, in order to develop stem cell therapeutics, three key challenges must be overcome: (i) identifying the stem or progenitor cells of a particular organ and testing them for therapeutic potential; (ii) creating processes to enable use of these rare cells in clinical applications, such as expanding and banking them in sufficient quantities to transplant into multiple patients; and (iii) demonstrating the safety and efficacy of these potential therapeutics in human clinical trials.

 

The Potential of Our Tissue-Derived Stem Cell-Based Therapy

 

We believe that, if successfully developed, stem cell therapeutics have the potential to provide a broad therapeutic approach comparable in importance to traditional pharmaceuticals and genetically engineered biologics. With respect to the human neural stem cells we have developed proprietary and reproducible processes to identify, isolate, expand, purify¹ and control the cells differentiation in mature functioning human neurons² and glia ³ and bank human neural stem cells from brain tissue. Because the cells are purified normal human neural stem cells, they may be better suited for transplantation and may provide a safer and more effective alternative to therapies that are based on cells derived from cancer cells, animal derived cells or are an unpurified mix of many different cell types.

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¹  Purification of our cells is the process whereby we separate “raw” donor tissue into our cells. During the process, we monitor the division of the neural stems cells and remove or “weed out” any cells which have failed to divide after a predetermined period of time. We repeat this process 3 to 4 times until the cells remaining have been “purified” in our estimation.

² Neurons are a major class of cells in the nervous system. Neurons are sometimes called nerve cells, though this term is technically imprecise since many neurons do not form nerves. In vertebrates, they are found in the brain, the spinal cord and in the nerves and ganglia of the peripheral nervous system, and their primary role is to process and transmit neural information. One important characteristic of neurons is that they have excitable membranes which allow them to generate and propagate electrical signals.

³ Glial cells, commonly called neuroglia or simply glia, are non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system. In the human brain, glia are estimated to outnumber neurons by as much as 50 to 1.

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Potential Markets

We believe that, if successfully developed, neural stem cell-based therapies have the potential to treat a broad range of diseases and injuries of the CNS. We believe the potential applications of our technologies given our current research focus includes developing neural cell therapies to treat Parkinson's disease, Amyotrophic Lateral Sclerosis (ALS), and injuries to the spinal cord.

We believe the potential markets for regenerative medicine based on our neural stem cell therapies are large. The table below summarizes the potential United States patient populations which we believe may be amenable to neural cell transplantation and represent potential target markets for our products:

POTENTIAL U.S. PATIENT POPULATIONS

FOR NEURAL CELL-BASED THERAPIES

 

Medical Condition		Number of Patients*
Parkinson's Disease		1 million
Spinal-cord injuries		0.25 million
Amyotrophic Lateral Sclerosis		0.03 million

 

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 ^* These estimates are based on the most current patient estimates published by the following organizations as of April 2006; the Parkinson's Disease Foundation, the Parkinson's Action Network, the Foundation for Spinal Cord Injury Prevention, Care and Cure, and the Amyotrophic Lateral Sclerosis Association.

Our Technology

Our technology is the ability to isolate human neural stem cells from most areas of the developing human brain and spinal cord and our technology includes the ability to grow them into physiologically relevant human neurons of all types. Our two issued core patents entitled Isolation, Propagation, and Directed Differentiation of Stem Cell from Embryonic and Adult Central Nervous System of Mammals and In Vitro Generation of Differentiated Neurons from Cultures of Mammalian Multi-potential CNS Stem Cell contain claims which cover the process of deriving the cells and the cells created from such process.

Our technology is the ability to isolate human neural stem cells from most areas of the developing human brain and spinal cord and to grow them into physiologically relevant human neurons of all types. Our core patents entitled:

·

Isolation, Propagation, and Directed Differentiation of Stem Cell from Embryonic and Adult Central Nervous System of Mammal; and

·

In Vitro Generation of Differentiated Neurons from Cultures of Mammalian Multi-potential CNS Stem Cell

contain claims which cover the details of this process and the culture of cells created. What differentiates our stem cell technology from others is that our patented processes do not require us to “push” the cells towards a certain fate by adding specific growth factors. Our cells actually “become” the type of cell they are fated to be. We believe this process and the resulting cells create a technology platform that allows for the efficient isolation and ability to produce, in commercially reasonable quantities, neural stem cells from the human brain and spinal cord.

Our technology allows for cells to grow in cultured dishes, also known as in vitro growth, without mutations or other adverse events that would compromise their usefulness. We believe this provides for two distinct advantages:

·

First, the growth or expansion of the cells in vitro occurs while the cells are still in their “stem cell” or blank state which allows for the creation of commercially reasonable quantities of neural stem cells. Once a sufficient number of blank cells have been grown, our technology allows us to program or differentiate the cells into either neurons or glia; and

 

·	Secondly, we have the ability to sample the cells while still in vitro in order to confirm that the cells are differentiating in the desired cell type.

 

Our technology also has ancillary uses with respect to drug development. Our ability to grow and differentiate neural cells in vitro , gives us the ability to analyze the potential biological effects of molecules on these cells. This has resulted in the identification of a group of small molecule compounds with the potential to enhance the survival of the endogenous cells residing in the hippocampus ³  region on the brain.

Business Strategy

 

We are seeking to develop and commercialize stem cell therapeutics to treat, and possibly cure, a range of human diseases. Our strategy has been to be the first to identify, isolate and patent important human neural stem and progenitor cells derived from human tissue with therapeutic and commercial importance; to develop techniques which enable the expansion and banking of those cells; and then to take them into clinical development as transplantable therapeutics.

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³  The hippocampus region of the brain plays a part in memory and navigation. We believe that this ability to enhance the survival rate of the endogenous cells may result in the development of drugs or compounds that could be used to treat a variety of central nervous system diseases.

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A central element of our business strategy is to obtain patent protection for the compositions, processes and uses of these multiple types of cells that would make the commercial development of neural stem cell therapeutics financially feasible. We have obtained rights to certain inventions relating to stem cells and progenitor through our own research and from academic collaborators. We expect to continue to expand our search for, and to seek to acquire rights from third parties where relevant relating to, neural stem and progenitor cells, and to further develop our intellectual property positions with respect to these cells in-house and through research at commercial and scholarly institutions.

Our Research and Programs

We have devoted substantial resources to our research programs to isolate and develop a series of neural stem cell banks that we believe can serve as a basis for therapeutic products. Our efforts to date have been directed at methods to identify, isolate and culture large varieties of stem cells of the human nervous system, and to develop therapies utilizing these stem cells. This research is conducted both internally and through the use of third party laboratory consulting companies under our direct supervision.

In addition to research which we conduct internally or under our direct supervision, we conduct research and development through research collaborations. These collaborations, or programs, are undertaken with both commercial and scholarly institutes pursuant to the terms and conditions of our standard material transfer agreement.

The material terms of our standard material transfer agreement requires us to provide our research partner or collaborator with access to our technology or “research materials,” which are comprised of our neurological stem cells, for a specific pre-defined purpose. As part of the agreement, we agree to provide sufficient research materials and technical assistance to accomplish the purpose of the program. The determination of sufficiency is determined at our sole discretion. As part of these agreements, we are entitled to certain reporting rights and the right to have patentable discoveries presented to us prior to publication in order for us to file applicable patents. In the event we choose to file a patent, we will either be responsible for all filing and maintenance fees or we will split the fees with our research partner depending on the type of patent to be filed. The agreements also provide for us to receive a fully paid up, royalty free, non-exclusive license to any inventions made by our partner with respect to our technologies and their interest in any intellectual property jointly developed and first right to negotiate an exclusive license. The agreements also provide confidentiality between the parties. Generally each party is responsible for its own expense, there are no milestone payment or royalty payment requirements and the duration of these agreements is for a three year term which can be terminated by either party with 90 days written notice.

The only agreement which varies from our general terms is the agreement pertaining to our work with the University of California San Diego. In addition to the general terms, the agreement also required us to provide a grant of $13,680, which we have already paid. We have no other payment obligations under any of our current material transfer agreements unless the studies result in findings which we choose to patent. We will then incur the costs associated with the filing and maintenance of such patent.

In addition to our general research regarding the application of our technology to central nervous systems diseases, we are presently involved in the following specific programs with our partners in order to demonstrate that our products work in small, non-statistically controlled studies (commonly referred to as proof-of-principle), in animal models:

University of California San Diego, San Diego, CA: In May of 2002, we initiated a research project with the University of California in San Diego for the purpose of researching the applicability of our technology to the treatment of Ischemic Spastic Paraplegia and traumatic spinal cord injury. The project is ongoing. The research yielded findings that contributed to our filing of patent entitled Transplantation of Human Cells for Treatment of Neurological Disorders.

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John Hopkins University, School of Medicine, Baltimore, MD: In March of 2001 we initiated a research project with John Hopkins University, School of Medicine for the purpose of researching the applicability of our technology to the treatment of Amyotrophic Lateral Sclerosis and traumatic spinal cord injury. The project is ongoing. The research yielded findings that contributed to our filing of patent entitled Transplantation of Human Cells for Treatment of Neurological Disorders.

University of Southern Florida, Tampa, FL: In September of 2005 we initiated a research project with the University of Southern Florida for the purpose of researching the applicability of our technology to the treatment of Parkinson's Disease. The project is ongoing.

University of Central Florida, Orlando, FL: In March of 2006 we initiated a research project with the University of Central Florida for the purpose of researching the applicability of our technology to the treatment of spinal cord injuries. The project is ongoing.

We have attached copies of the material transfer agreements governing the above collaborations as exhibits to this prospectus.

Our Grants

In August of 2005 we were awarded a two year, $500,000 Small Business Innovation Research non competitive grant from the National Institute of Health (NIH), to further our research with regard to depression. Under the terms of the grant, we submit an annual budget of $250,000 to be used for the purpose of testing our compounds in various models of depression. Any changes or modifications to the submitted budget must be approved by case manager. After we incur expenses, we submit those expenses to the NIH for reimbursement. The grant covers salary, wages, personnel costs, supplies, travel costs, and consortium/contractual costs with regard to the research.

 

The only conditions to full funding of the grant are that we use the proceeds to further or research regarding depression and that we use the funds as budgeted. Notwithstanding, in the event of a budget variance, we can seek approval of such variance from the case manager and such variance would be funded provided the aggregate funding does not exceed the amount of the grant. As of July 31, 2006, we have received an aggregate of $160,000 pursuant to this grant.

 

Our Intellectual Property Licensed to Others

 The following summarizes licenses from us to third parties.

A-T Children's Project. On December 22, 2004, we entered into a non exclusive limited license and material transfer agreement with A-T Children's Project (“A-TCP”), pursuant to which we granted to A-TCP a non-exclusive limited license to use all of our intellectual property for use in developing suitable tests for screening compounds to treat Ataxia-Telangiectasia. The license limits the use of our cells in vitro for compound screen development and not for any therapeutic use of the cells. In consideration of the rights and licenses granted to A-TCP, A-TCP paid to us a one time payment of $37,500.

The initial term of A-TCP license is for a period of 10 years and contains certain conditions as to confidentiality which will survive the term. The agreement does not make any provisions for early termination by the parties and is silent with regard to notice requirements. The agreement does not contain any indemnification provisions or conditions regarding infringement or right to defend.

   

Biomedical Research Models, Inc. License. On February 7, 2005, we entered into an exclusive, worldwide, royalty-bearing license with Biomedical Research Models, Inc. (“BRM”), pursuant to which we exclusively licensed to BRM certain technology and patent rights embodied in our patent application entitled “Use of Fused Imidazoles, Aminopyrimidines, Isonicotinamides, Aminomethyl Phenoxypiperidines and Aryloxypiperidines to Promote and Detect Endogenous Neurogenesis.” Under the agreement, we license rights to certain patent rights and technology useful as compounds and therapeutic agents to treat diabetes and its complications.

Under the terms of the agreement, BRM is obligated to pay us an annual license fee of $75,000 on January 1, 2007 and 2008. In the event a milestone payment becomes due during this period, the annual payments will cease and the last amounts paid will be credited towards the milestone payment. BRM has agreed to the following milestone payments:

 

(i)	$750,000 within 30 days of initiating Phase I clinical trials (Milestone 1);

 

(ii)	$1,000,000 within 30 days of initiating Phase II clinical trials (Milestone 2);

 

(iii)

$1,500,000 within 30 days of initiating Phase III clinical trials (Milestone 3);

 

(iv)	$35,000,000 within one year after full commercial approval and licensure is granted by the United States Food and Drug Administration (Milestone 4); and

 

(v)	A one time sale bonus of $100 million within one year after the first time the aggregate net sales of any licensed product by BRM reaches $1.0 billion.

 

 

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Under the terms of the agreement, BRM shall also pay us royalties of 7.0% of net sales of products they market directly, or 20% of any sub-license income. For a more detailed description of the BRM license, please refer to the exclusive licensing agreement filed as an exhibit to this prospectus.

 

The term of the BRM license is for a period of 15 years however the agreement provides for early termination in the event that BRM does not undertake diligence to develop product and introduce those products into the commercial market. The agreement can also be terminated in the event of a material breach by the other party upon 90 days written notice.

The agreement also requires BRM to indemnify Neuralstem against any liability incurred as a result of BRM’s use of the technology but excludes any liability as a result of our gross negligence or intentional activities. Additionally, the agreement provides that all costs associated with the preparation, filing, prosecution and maintenance of all Neuralstem patent rights under the agreement will be the sole responsibility of BRM. The agreement also grants BRM the right to prosecute and or defend against any third party infringement of the licensed intellectual property at its sole expense. In the event that BRM does not prosecute or defend against an infringement within a reasonable time of becoming aware of such infringement, Neuralstem shall have the right to prosecute such infringement.

 

High Med Technologies, Inc. License.    On July 7, 2005, we entered into a limited exclusive, licensing agreement relating to the sales, distribution and marketing of our technology by High Med Technologies, Inc. (HiMed). Under the agreement, we granted HiMed the exclusive right (excluding Neuralstem) to create, manufacture, develop, sublicense or offer for sale our technology for the sole purpose of in vitro research that does not involve the injection of cells or cell-derivative materials into living animals or human beings. Accordingly, we have limited HiMed use under the license to in vitro uses, and there is no license for any therapeutic use of the cells. As part of the agreement, HiMed has agreed to certain revenue targets which if met, will extend the term of this agreement from five years to the life of all applicable patents. Accordingly, we have licensed HiMed any and all technology that we control, but only for limited in vitro uses mentioned above.

As compensation under the license, we will be entitled to:

 

·	80% of revenues obtained by HiMed where HiMed does not manufacture and supply the product to the customer; and

 

·	20% of revenues obtained by HiMed where HiMed is required to manufacture and supply the product to the customer.

 

We have also agreed that should we directly supply a customer who is or was a customer of HiMed, we will be required to pay HiMed 20% of any revenues received therefrom.

The initial term of the HiMed license is for a period of 5 years but automatically extends to the life of certain patents in the event annual target revenues are met. The agreement does not make any provisions for early termination by the parties and is silent with regard to notice requirements. The agreement does not contain any indemnification provisions or conditions regarding infringement or right to defend.

 

Manufacturing

 

We currently manufacture our cells both in-house and on an outsource basis. We manufacture cells in-house which are not required to meet stringent FDA requirements. We use these cells in our research grant and collaborative programs. We outsource all the manufacturing and storage of our stem cells to be used in pre-clinical works, and which are accordingly subject to the higher FDA requirements, to Charles River Laboratories, Inc., of Wilmington, Massachusetts. The Charles River facility has the capacity to be used for cell processing under the FDA determined Good Manufacturing Practices (GMP) in quantities sufficient for our current pre-trial and anticipated future clinical trial needs. We believe the facility has sufficient capacity to provide for our needs in the near to intermediate term. We have no quantity or volume commitment with Charles River Laboratories and our cells are ordered and manufactured on an as needed basis.

Products & Marketing

 

Because of the early stage of our programs, we have yet to identify any specific product and we have not yet addressed questions of channels of distribution and marketing of potential future products. We are however focusing our efforts on applications of our technology to diseases that affect the central nerve system.

 

Our Intellectual Property

Our research and development is supported by our intellectual property. We currently own or have exclusive licenses to 4 patents and 12 patent applications pending worldwide in the field of regenerative medicine and stem cell therapy.

Our success will likely depend upon our ability to preserve our proprietary technologies and operate without infringing the proprietary rights of other parties. However, we may rely on certain proprietary technologies and know-how that are not patentable. We protect our proprietary information, in part, by the use of confidentiality agreements with our employees, consultants and certain of our contractors.

When appropriate, we seek patent protection for inventions in our core technologies and in ancillary technologies that support our core technologies or which we otherwise believe will provide us with a competitive advantage. We accomplish this by filing patent applications for discoveries we make, either alone or in collaboration with scientific collaborators and strategic partners. Typically, although not always, we file patent applications both in the United States and in select international markets. In addition, we plan to obtain licenses or options to acquire licenses to patent filings from other individuals and organizations that we anticipate could be useful in advancing our research, development and commercialization initiatives and our strategic business interests.

 

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The following table identifies the issued and pending patents we own that we believe currently support our technology platform.

Patents Pending

Number		Country		Filing Date		Issue Date		Expiration Date		Title
97923569.4		EP		05/07/97		Pending		N/A		Isolation, Propagation, and Directed Differentiation of Stem Cell from Embryonic and Adult Central Nervous System of Mammals
2257068		CA		05/07/97		Pending		N/A		Isolation, Propagation, and Directed Differentiation of Stem Cell from Embryonic and Adult Central Nervous System of Mammals
99948396.9		EP		09/20/99		Pending		N/A		Stable Neural Stem Cell Lines
2002-526065		JAP		09/20/99		Pending		N/A		Stable Neural Stem Cell Lines
2343571		CA		09/20/99		Pending		N/A		Stable Neural Stem Cell Lines
10/047,352		US		01/14/02		Pending		N/A		Stable Neural Stem Cells
10/728,652		US		12/05/03		Pending		N/A		Method for Discovering Neurogenic Agents
2004/053071		WO		12/05/03		Pending		N/A		Method for Discovering Neurogenic Agents
10/914,460		US		08/09/04		Pending		N/A		Use of Fused Imidazoles, Aminopyrimidines, Isonicotinamides, Aminomethyl Phenoxypiperidines and Aryloxypiperidines to Promote and Detect Endogenous Neurogenesis
1576134		EP		12/05/03		Pending		N/A		Method for Discovering Neurogenic Agents
11/281,640		US		11/17/05		Pending		N/A		Transplantation of Human Cells for Treatment of Neurological Disorders
PCT/US05/41367		WO		11/17/05		Pending		N/A		Transplantation of Human Cells for Treatment of Neurological Disorders

Patents Issued

Number		Country		Filing Date		Issue Date		Expiration Date		Title
5,753,506		US		09/25/96		05/19/98		09/25/2016		Isolation, Propagation, and Directed Differentiation of Stem Cell from Embryonic and Adult Central Nervous System of Mammals
6,040,180		US		05/07/97		03/21/00		09/25/2016		In Vitro Generation of Differentiated Neurons from Cultures of Mammalian Multi-potential CNS Stem Cell
6,284,539		US		10/09/98		09/04/01		10/9/2018		Method for Generating Dopaminergic Cells Derived from Neural Precursors
755849		Australia		09/22/99		04/03/03		09/20/2019		Stable Neural Stem Cell Lines

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We also rely upon trade-secret protection for our confidential and proprietary information and take active measures to control access to that information.

 

Our policy is to require our employees, consultants and significant scientific collaborators and sponsored researchers to execute confidentiality agreements upon the commencement of an employment or consulting relationship with us. These agreements generally provide that all confidential information developed or made known to the individual by us during the course of the individual's relationship with us is to be kept confidential and not disclosed to third parties except in specific circumstances. In the case of employees and consultants, the agreements generally provide that all inventions conceived by the individual in the course of rendering services to us shall be our exclusive property.

The patent positions of pharmaceutical and biotechnology companies, including ours, are uncertain and involve complex and evolving legal and factual questions. The coverage sought in a patent application can be denied or significantly reduced before or after the patent is issued. Consequently, we do not know whether any of our pending applications will result in the issuance of patents, or if any existing or future patents will provide significant protection or commercial advantage or will be circumvented by others. Since patent applications are secret until the applications are published (usually eighteen months after the earliest effective filing date), and since publication of discoveries in the scientific or patent literature often lags behind actual discoveries, we cannot be certain that we were the first to make the inventions covered by each of our pending patent applications or that we were the first to file patent applications for such inventions. There can be no assurance that patents will issue from our pending or future patent applications or, if issued, that such patents will be of commercial benefit to us, afford us adequate protection from competing products, or not be challenged or declared invalid.

 

In the event that a third party has also filed a patent application relating to inventions claimed in our patent applications, we may have to participate in interference proceedings declared by the United States Patent and Trademark Office to determine priority of invention, which could result in substantial uncertainties and cost for us, even if the eventual outcome is favorable to us. There can be no assurance that our patents, if issued, would be held valid by a court of competent jurisdiction.

 

A number of pharmaceutical, biotechnology and other companies, universities and research institutions have filed patent applications or have been issued patents relating to cell therapy, stem cells and other technologies potentially relevant to or required by our expected products. We cannot predict which, if any, of such applications will issue as patents or the claims that might be allowed.

 

If third party patents or patent applications contain claims infringed by our technology and such claims are ultimately determined to be valid, there can be no assurance that we would be able to obtain licenses to these patents at a reasonable cost, if at all, or be able to develop or obtain alternative non-infringing technology. If we are unable to obtain such licenses or develop or obtain alternative non-infringing technology at a reasonable cost, we may not be able to develop certain products commercially. There can be no assurance that we will not be obliged to defend ourselves in court against allegations of infringement of third party patents. Patent litigation is very expensive and could consume substantial resources and create significant uncertainties. An adverse outcome in such a suit could subject us to significant liabilities to third parties, require us to seek licenses from third parties, or require us to cease using such technology.

Competition

The biotechnology industries are characterized by rapidly evolving technology and intense competition. Our competitors include major multinational pharmaceutical companies, specialty biotechnology companies and chemical and medical products companies operating in the fields of regenerative medicine, cell therapy, tissue engineering and tissue regeneration. Many of these companies are well-established and possess technical, research and development, financial and sales and marketing resources significantly greater than ours. In addition, certain smaller biotech companies have formed strategic collaborations, partnerships and other types of joint ventures with larger, well established industry competitors that afford these companies potential research and development and commercialization advantages. Academic institutions, governmental agencies and other public and private research organizations are also conducting and financing research activities which may produce products directly competitive to those we are developing. Moreover, many of these competitors may be able to obtain patent protection, obtain FDA and other regulatory approvals and begin commercial sales of their products before we do.

In the general area of cell-based therapies, we compete with a variety of companies, most of whom are specialty biotechnology companies. Some of these, such as Geron Corporation, Genzyme Corporation, StemCells, Inc., Aastrom Biosciences, Inc. and Viacell, Inc., are well-established and have substantial technical and financial resources compared to us. However, as cell-based products are only just emerging as medical therapies, many of our direct competitors are smaller biotechnology and specialty medical products companies. These smaller companies may become significant competitors through rapid evolution of new technologies. Any of these companies could substantially strengthen their competitive position through strategic alliances or collaborative arrangements with large pharmaceutical or biotechnology companies.

The diseases and medical conditions we are targeting have no effective long-term therapies. Nevertheless, we expect that our technologies and products will compete with a variety of therapeutic products and procedures offered by major pharmaceutical companies. Many pharmaceutical and biotechnology companies are investigating new drugs and therapeutic approaches for the same purposes, which may achieve new efficacy profiles, extend the therapeutic window for such products, alter the prognosis of these diseases, or prevent their onset. We believe that our products, when and if successfully developed, will compete with these products principally on the basis of improved and extended efficacy and safety and their overall economic benefit to the health care system.

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Competition for any stem cell products that we may develop may be in the form of existing and new drugs, other forms of cell transplantation, surgical procedures, and gene therapy. We believe that some of our competitors are also trying to develop similar stem cell-based technologies. We expect that all of these products will compete with our potential stem cell products based on efficacy, safety, cost and intellectual property positions. We may also face competition from companies that have filed patent applications relating to the use of genetically modified cells to treat disease, disorder or injury. In the event our therapies should require the use of such genetically modified cells, we may be required to seek licenses from these competitors in order to commercialize certain of our proposed products, and such licenses may not be granted.

·	On November 7, 2005 we converted a note in the amount of $100,000 payable to Mr. Stanley Westreich. As part of the conversion, we issued Mr. Westreich: (i) 200,000 shares of our common stock; and (ii) a warrant to purchase 200,000 common shares at $.50.

 

DESCRIPTION OF SECURITIES

General

Our authorized capital consists of (1) 75,000,000 shares of common stock, par value $.001 per share, and (2) 7,000,000 shares of “blank check” preferred stock, par value $.001 per share.

Common Stock

The holders of our common stock are entitled to one vote per share on each matter submitted to a vote at a meeting of our stockholders, except to the extent that the voting rights of our shares of any class or series of stock are determined and specified as greater or lesser than one vote per share in the manner provided by our certificate of incorporation. Our stockholders have no pre-emptive rights to acquire additional shares of our common stock or other securities. Our common stock is not subject to redemption rights and carries no subscription or conversion rights. In the event of liquidation of our company, the shares of our common stock are entitled to share equally in corporate assets after satisfaction of all liabilities. All shares of our common stock now outstanding are fully paid and non-assessable. Our bylaws authorize the board of directors to declare dividends on our outstanding shares. As of August 25, 2006 there are 25,820,939 shares of our common stock issued and outstanding.

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Preferred Stock

We may issue our preferred shares from time to time in one or more series as determined by our board of directors. The voting powers and preferences, the relative rights of each series, and the qualifications, limitations and restrictions thereof may be established by our board of directors without any further vote or action by our shareholders. As of August 25, 2006 there were no shares of our preferred stock issued and outstanding.

 

Options and Warrants Convertible into Common Shares

As of August 25, 2006, there were outstanding common share purchase options or warrants entitling the holders to purchase up to 11,121,667 common shares at exercise prices between $0.05 and $10.00 with an average weighted exercise price of $1.61 per share.

EQUITY COMPENSATION PLAN INFORMATION

 

The following table sets forth information with respect to our 2005 Stock Plan as of August 25, 2006.

		(a)			(b)			(c)
		Number of Securities to be Issued upon Exercise of Outstanding Options, Warrants and Rights			Weighted-Average Exercise Price of Outstanding Options, Warrants and Rights			Number of Securities Remaining Available or Future Issuance under Equity Compensation Plans (Excluding Securities Reflected in Column (a))
Equity compensation plans approved by security holders			2,400,000		$	.50			1,600,000
Equity compensation plans not approved by security holders			N/A			N/A			N/A
Total			2,400,000		$	.50			1,600,000

2005 Stock Plan

 

Our board of directors adopted the 2005 Stock Plan on July 27, 2005, and it was subsequently approved by our stockholders. The 2005 Stock Plan provides for the grant of stock options or stock to our employees, directors, and consultants. As of August 25, 2006 options to purchase a total of 2,400,000 shares of common stock were outstanding under the 2005 Stock Plan at a weighted average exercise price of $.50 per share. At August 25, 2006, 1,600,000 shares of our common stock remained available for future issuance under our 2005 Stock Plan.

 

Administration of the 2005 Stock Plan.    Our board of directors administers our 2005 Stock Plan. The administrator has the power to determine the terms of the awards, including the exercise price (which may be changed by the administrator after the date of grant), the number of shares subject to each award, the exercisability of the awards and the form of consideration payable upon exercise.

 

Options.    A stock option is the right to purchase shares of our common stock at a fixed exercise price for a fixed period of time. The administrator will determine the exercise price of options granted under our 2005 Stock Plan. Notwithstanding, pursuant to the plan, the exercise price of any option granted shall in no event be less than the lesser of: (i) the book value per share of common stock as of the end of the fiscal year immediately preceding the date of such grant; or (ii) fifty percent (50%) of the fair market value per share of the common stock on the date of grant.

Transferability of Awards.    Unless the administrator determines otherwise, our 2005 Stock Plan does not allow for the transfer of awards other than by will or by the laws of descent and distribution, and only the participant may exercise an award during his or her lifetime.

 

Amendment and Termination of Our 2005 Stock Plan.    Our 2005 Stock Plan will automatically terminate in 2010, unless we terminate it sooner. In addition, our board of directors has the authority to amend, suspend or terminate our 2005 Stock Plan without shareholder consent.

MARKET FOR COMMON EQUITY & RELATED STOCKHOLDER MATTERS 

 

Market Information

 

There exists no market for our common stock. Private sales or transfers are permitted under the respective state and Federal securities laws, subject to compliance with exemptions set forth under the respective statutory guidelines.  As of August 25, 2006, we had 157 shareholders of record. We anticipate this number to dramatically increase upon the issuance of the Regal One Corporation stock dividend as further described in the section titled “Additional Selling Shareholders.”

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Dividend Policy

Holders of the Company's Common Stock are entitled to receive dividends should they be declared by the Board of Directors, out of funds legally available for distribution. Any such dividends may be paid in cash, property or shares of the Company's common stock. The Company has not paid any dividends since its inception, and it is not likely that dividends on its Common Stock will be declared at any time in the foreseeable future. Any dividends will be subject to the discretion of the Company's Board of Directors, and will depend upon, among other things, the operating and financial condition of the Company, its capital requirements and general business conditions. Therefore, there can be no assurance that any dividends on the Company's Common Stock will be paid in the future.

SHARES ELIGIBLE FOR FUTURE SALE

 

To date, there has been no market for our common stock. In the event a public market for our shares develops, future sales of substantial amounts of our common stock in the public market could adversely affect prevailing market prices from time to time. Further, since only a limited number of shares will be available for sale shortly after this offering because of certain contractual and legal restrictions on resale described below, sales of substantial amounts of our common stock in the public market after the restrictions lapse could adversely affect the prevailing market price and our ability to raise equity capital in the future.

 

Sales of Restricted Shares

As of August 25, 2006, we have issued and outstanding an aggregate of 25,820,939 shares of common stock. Of these shares, the 8,088,667 common shares being registered in this prospectus, excluding those shares issuable upon the exercise of options and warrants, will be freely tradable without restrictions or further registration under the Securities Act, unless one or more of our existing affiliates as that term is defined in Rule 144 under the Securities Act purchases such shares.

 

The remaining 17,739,272 shares of our common stock held by existing stockholders as of August 25, 2006 are restricted shares or are restricted by the contractual provisions described below. Restricted shares may be sold in the public market only if registered or if they qualify for an exemption from registration under Rule 144 or Rule 701 of the Securities Act, which are summarized below. Of these restricted shares, 12,822,317 shares are available for resale in the public market in reliance on Rule 144(k) as of August 25, 2006. An additional 3,894,668 shares will be available for resale in the public market in reliance on Rule 144 as of August 25, 2006. The remaining 1,015,287 shares become eligible for resale in the public market at various dates thereafter. Notwithstanding the foregoing, 6,178,211 shares which would otherwise be subject to Rule 144(k) and 3,894,668 shares which would otherwise be eligible under Rule 144, are restricted by lock up agreement for a period of 12 months.

 

The table below sets forth the approximate number of shares eligible for future sale:

Date		Number of Shares
On the date of this prospectus			14,707,689
Within 90 days after the date of this prospectus			15,722,976
Between 90 and 180 days after the date of this prospectus			15,722,976
At various times beginning more than 180 days after the date of this prospectus			25,820,939

 

Rule 144

Under Rule 144 as currently in effect, beginning 90 days after the date of this prospectus, a stockholder who has beneficially owned restricted shares for at least one year and has complied with the requirements described below would be entitled to sell, upon the expiration of the lock-up agreements described below, some of that stockholder's shares within any three-month period. That number of shares cannot exceed the greater of one percent of the number of shares of our common stock then outstanding, which will equal approximately 258,209 shares immediately after this offering, or the average weekly trading volume of our common stock during the four calendar weeks preceding the filing of a notice on Form 144 reporting the sale. Sales under Rule 144 are also restricted by manner of sale provisions, notice requirements and the availability of current public information about us. Rule 144 also provides that our affiliates who are selling shares of our common stock that are not restricted shares must nonetheless comply with the same restrictions applicable to restricted shares with the exception of the holding period requirement.

 

Under Rule 144(k), a person who is not deemed to have been one of our affiliates at any time during the 90 days preceding a sale and who has beneficially owned the shares proposed to be sold for at least two years is entitled to sell those shares without complying with the manner of sale, public information, volume limitation or notice provisions of Rule 144. Accordingly, these shares may be sold without restriction immediately upon the expiration of the lock-up agreements described below.

Rule 701

Rule 701 provides that the shares of common stock acquired upon the exercise of currently outstanding options or other rights granted under our equity plans may be resold, by persons, other than affiliates, beginning 90 days after the date of this prospectus, restricted only by the manner of sale provisions of Rule 144, and by affiliates in accordance with Rule 144, without compliance with its one-year minimum holding period.

 

34

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Registration Statements

We intend to file one or more registration statements on Form S-8 under the Securities Act following this offering to register all shares of our common stock which have been issued or are issuable upon exercise of outstanding stock options or other rights granted under our equity plans. These registration statements are expected to become effective upon filing. Shares covered by these registration statements will thereupon be eligible for sale in the public market, upon the expiration or release from the terms of the lock-up agreements, to the extent applicable, or subject in certain cases to vesting of such shares.

Lock-up Agreements

As a condition to our March 2006 private placement, certain stockholders, warrant holders and option holders, representing 10,392,879 shares of our common stock on an as converted as exercised basis, have agreed with us not to sell or otherwise dispose of, directly or indirectly, any shares of our common stock (or any security convertible into or exchangeable or exercisable for common stock) for a period of 12 months following the effectiveness of this registration statement without the express consent of T.R. Winston & Company.

 

SELLING SHAREHOLDERS

 

The following table depicts the total number of common shares beneficially owned or acquirable by each of the selling shareholders as of August 25, 2006, the total number of common shares they may sell under this prospectus, and the number of common shares they will own thereafter assuming the sale of all shares offered under this prospectus and further assuming no other acquisitions or dispositions of common shares. The number and percentage of shares beneficially owned is determined in accordance with Rule 13d-3 and 13d-5 of the Exchange Act which calculates ownership based solely upon sole or shared voting power or investment power, and the information is not necessarily indicative of the beneficial ownership for any other purpose, including the determination of direct or indirect pecuniary ownership. We believe that each individual or entity named has sole investment and voting power with respect to the securities indicated as beneficially owned by them, subject to community property laws, where applicable, except where otherwise noted.

The selling shareholders are under no obligation to sell all or any portion of the common shares offered for sale under this prospectus.

The total number of common shares sold under this prospectus may be adjusted to reflect adjustments due to stock dividends, stock distributions, splits, combinations, recapitalizations or the triggering standard of weighted-average and other anti-dilution protective provisions.

Unless otherwise stated below, to our knowledge no selling shareholder nor any affiliate of such shareholder has held any position or office with, been employed by or otherwise has had any material relationship with us or our affiliates during the three years prior to the date of this prospectus.

35

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36

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		Common Shares Owned Before Sale(1)														Common Shares Owned After Sale
Selling Shareholder		Held Outright			Warrants/ Options (3)			Amount			% of Class			Shares being registered		Amount			% of Class
Michael Berry			50,000			-			50,000			*		50,000			-			-
Michael Diamant			25,083			25,083			50,167			*		50,167			-			-
Michael J. Garr			40,133			40,133			80,266			*		80,266			-			-
Michael W. Engmann			150,500			150,500			301,000			1.2	%	301,000			-			-
Mitchell Sassower			50,167			50,167			100,333			*		100,333			-			-
Nathan Sugerman			100,167			50,167			150,333			*		150,333			-			-
New Horizon Exploration Inc.(16)			25,083			25,083			50,167			*		50,167			-			-
Omicron Master Trust(17)			250,833			250,833			501,667			1.9	%	501,667			-			-
Patrick Hund			75,083			25,083			100,167			*		100,167			-			-
PaulPaul A. Lobel and Laura A. Lobel, Tenants by Entirety			25,083			25,083			50,167			*		50,167			-			-
Phillip S. Sassower Charitable Remainder Annuity Trust '96 (18)			100,333			100,333			200,667			*		200,667			-			-
RBC Dain Rauscher Custodian FBO Gregory B. Pepus IRA			35,117			35,117			70,233			*		70,233			-			-
Regal One Corporation(19) (30)			1,815,287			1,000,000			2,815,287			10.9	%	800,000			1,015,287			3.9	%
Richard Friedman			50,167			50,167			100,333			*		100,333			-			-
Richard Green			50,000			-			50,000			*		50,000			-			-
Richard Hull			25,083			125,083			150,167			*		50,167			100,000			*
Richard Stone			50,000			-			50,000			*		50,000			-			-
Robert Cohan			50,167			50,167			100,333			*		100,333			-			-
Robert Lempert			20,067			20,067			40,133			*		40,133			-			-
Robert R. Kauffman			75,250			75,250			150,500			*		150,500			-			-
Rubicon Global Value Fund, L.P.(20)			145,483			145,483			290,966			1.1	%	290,966			-			-
S&J Veal, Inc. (21)			25,083			25,083			50,167			*		50,167			-			-
S.W. Bach & Company(22)(28)						127,050			127,050			*		127,050			-			-
Sachs Investing Co. (23)			50,167			50,167			100,333			*		100,333			-			-
Sam R. Buck			131,437			131,437			262,873			1.0	%	262,873			-			-
Silpi Polepalle			25,083			25,083			50,167			*		50,167			-			-
Steven B. Dunn			500,000			-			500,000			1.9	%	500,000			-			-
Steven Mitchell Sack			172,333			100,333			272,667			1.1	%	272,667			-			-
Sylvia Johe			25,083			25,083			50,167			*		50,167			-			-
T.R. Winston & Company, LLC (24) (28)						672,950			672,950			2.6	%	672,950			-			-
The JD Group, LLC(25)						1,000,000			1,000,000			3.9	%	1,000,000			-			-
Thomas E. Genna			150,167			50,167			200,333			*		200,333			-			-
Thomas R. Smith			50,167			50,167			100,333			*		100,333			-			-
Univest Management Employee Profit Sharing Plan (26)			50,167			50,167			100,333			*		100,333			-			-
VAR Growth Corp.(27)			100,000			-			100,000			*		100,000			-			-
William John Reininger			25,083			25,083			50,167			*		50,167			-			-
Reserved Penalty Shares (31)			50,000			50,000			100,000			*		100,000			-			-
Total			9,153,954			8,296,666			17,450,620			67.2	%	16,335,333			1,115,287			4.3	%

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* Less Than 1%

 

(1)

Pursuant to Rules 13d-3 and 13d-5 of the Exchange Act, beneficial ownership includes any common shares as to which a shareholder has sole or shared voting power or investment power, and also any common shares which the shareholder has the right to acquire within 60 days, including upon exercise of common shares purchase options or warrants. There were 25,820,939 common shares outstanding as of August 25, 2006.

 

(2)	Assumes the sale of all common shares offered under this prospectus.

 

37

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(3)	Unless otherwise stated, shares underlying warrants/options constitute common shares issuable upon the exercise of Class A and B warrants in ratio of 50/50.

(4)	Dr. Keicher is the person with voting and dispositive power of Aton Select Fund Limited.

(5)	Mr. Bradley Ross is the person with voting and dispositive power of B&R Richie's.

(6)	Mr. Engelhardt Schreiber is the person with voting and dispositive power of Condor Financial Management S.A.

(7)	Mr. Ira Weingarten is the person with voting and dispositive power of Equity Communications, LLC.

(8)	Mr. Malcolm R. Currie is the person with voting and dispositive power of Freddie Bear Partnership.

(9)	Mr. Arthur L. Hawkins is the Trustee and person with voting and dispositive power of the Hawkins Family Trust.

(10)	Mr. Tyler Runnels is the person with voting and dispositive power of High Tide, LLC.

(11)	Mr. Joshua Silverman is the person with voting and dispositive power of Iroquois Master Fund, Ltd.

(12)	Mr. Alexander M. Goren is the person with voting and dispositive power of JAG Multi Investments, LLC

(13)	Mr. Leonard Pearlman is the person with voting and dispositive power of JAM Capital Associates, LLC

(14)	Mr. Jonathan Glaser is the person with voting and dispositive power of JMG Capital Partners, LP

(15)	Mr. Jonathan Glaser is the person with voting and dispositive power of JMG Triton Offshore Fund, Ltd.

(16)	Mr. Rex E. Gifford is the person with voting and dispositive power of New Horizon Exploration.

(17)	Mr. Bruce Bernstein is the person with voting and dispositive power of Omicron Master Trust.

(18)	Mr. Phillip S. Sassower is the Trustee and person with voting and dispositive power of the Philip S. Sassower Charitable Remainder Annuity Trust `96.

(19)	The people with voting and dispositive with regard to the shares is the board of directors of Regal One, Inc.

(20)	Mr. Steven Shum is the person with voting and dispositive power of Rubicon Global Value Fund, L.P.

(21)	Mr. Scott Turriff is the person with voting and dispositive power of S&J Veal, Inc.

(22)	Mr. Clemente is the person with voting and dispositive power of S.W. Bach & Company.

(23)	Mr. Marvin Sach is the person with voting and dispositive power of Sachs Investment Co.

(24)	Mr. Tyler Runnels is the person with voting and dispositive power of T.R. Winston & Company, LLC.

(25)	Mr. John Davies is the person with voting and dispositive power of the JD Group, LLC.

(26)	Mr. Frank Gerardi is the person with voting and dispositive power of Univest Management Employee Profit Sharing Plan.

(27)	Ms. Doris Sutz is the person with voting and dispositive power of VAR Growth Corp.

(28)	Warrants received as part of compensation pursuant to a placement agency agreement between us and the selling shareholders. Accordingly, such shares are restricted in accordance with Rule 2710(g)(1) of the NASD Conduct Rules.

 

38

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(29)

The selling shareholder is an affiliate of a broker-dealer. At the time of purchasing the securities, the selling stockholder had no agreement or understanding, directly or indirectly, with any person to distribute such securities or any securities issuable upon conversion or exercise. The selling shareholder purchased the securities in the ordinary course of business.

 

(30)	Includes 500,361 shares to be distributed as a dividend to the shareholders of Regal One Corporation which are listed below as “Additional Selling Shareholders.”

 

(31)	Includes 100,000 common shares which we may become obligated to issue as a penalty related to certain registration rights. For a more detailed discussion, see that section of this prospectus entitled “Registration Rights”

  

 

 

ADDITIONAL SELLING SHAREHOLDERS

On January 23, 2006, one of our majority shareholders, Regal One Corporation, announced a stock dividend of our common shares which it current holds. The dividend will be issused to Regal One Corporation shareholder of record on February 15, 2006. As a result, the following Regal One Corporation shareholders will receive shares of our common stock as a dividend and be entitled to sell them under this prospectus.

	Common Shares Owned Before Sale(1)						Common Shares Owned After Sale(2)
Selling Shareholder	Held Outright	Warrants/ Options(3)	Amount		Shares being registered		Amount

AB Investments, Inc (3)	134,596	-	134,596		134,596		-
Malcolm R. Currie	70,923	-	70,923		70,923		-
CB Family Trust (4)	49,053	-	49,053		49,053		-
Aaron Grunfeld	42,045	-	42,045		42,045		-
Robert B. Kay	36,239	-	36,239		36,239		-
Allen Richard Smith (10)	11,680	-	11,680		11,680		-
Douglas Burke (10)	11,680	-	11,680		11,680		-
Hofer Family Trust (10)	11,680	-	11,680		11,680		-
Dieterich & Associates (5)	10,512	-	10,512		10,512		-
Michael Platt	8,760	-	8,760		8,760		-
Mid America Capital Corp (6)	8,760	-	8,760		8,760		-
CJ Newman	8,312	-	8,312		8,312		-
Christopher Dieterich	3,504	-	3,504		3,504		-
Sandra Jarrett	2,628	-	2,628		2,628		-
Gerrish Family Trust	2,208	-	2,208		2,208		-
Gaylan Rockswold	2,173	-	2,173		2,173		-
Randall Jarrett	1,752	-	1,752		1,752		-
Frederick Barak	1,109	-	1,109		1,109		-
W J Reininger	1,052	-	1,052		1,052		-
Yifal J Shaham & Brach Shaham	1,052	-	1,052		1,052		-
Charles Stevens	876	-	876		876		-
The Metaphase Group (7)	701	-	701		701		-
Don Gorodetzky	482	-	482		482		-
Thomas Baar	474	-	474		474		-
David Paletz	438	-	438		438		-
Smith Barney Inc	373	-	373		373		-
Kiki Borlenghi	357	-	357		357		-
Louis D'Alto & Tonian D'Alto	357	-	357		357		-
Richard Abruscato	357	-	357		357		-
The Rose Group (8)	357	-	357		357		-
Walter K Theis	263	-	263		263		-
Joseph G Le Bleu	228	-	228		228		-
Louis Kulekofsky	176	-	176		176		-
Susan Delman	176	-	176		176		-
Lynette M Eagan	169	-	169		169		-
H T Frankhouser	159	-	159		159		-
Stuart G Mccampbell	138	-	138		138		-
Eric Stanton	132	-	132		132		-
William E Kearney & Judy J Kearney	132	-	132		132		-
Small Business Administration	130	-	130		130		-
George C Anderson	106	-	106		106		-
Leonard Krasinski	97	-	97		97		-
Kathryn J. Roth	88	-	88		88		-
Lloyd Peterson	88	-	88		88		-
Nili Shamrat	88	-	88		88		-
Robert E Hopper & Margaret J Hopper	88	-	88		88		-
Sean P Flanagan & Darrelyn A Flanagan	88	-	88		88		-
Realty Investment Concepts	76	-	76		76		-
George Crile	64	-	64		64		-
Herbert J Tamres	55	-	55		55		-
Aaron Nachshoni	51	-	51		51		-
Thomas L Rotello	49	-	49		49		-
K Andrew Kroese	44	-	44		44		-
Scott G Hill	44	-	44		44		-
Sidney Weisberg	44	-	44		44		-
Robert Newell	39	-	39		39		-
Ahuva A Rubinstein	36	-	36		36		-
Terry V Chastain	36	-	36		36		-
David A Moxon & Kelly A Moxon	31	-	31		31		-
Fred Magargee & Jill H Magargee	29	-	29		29		-
Robert Genova	27	-	27		27		-
1988 Childrens Trust (9)	23	-	23		23		-
Harry Bramson & Laureen Bramson	23	-	23		23		-
Louis Anthoney Marks	23	-	23		23		-
Seymour Levine	23	-	23		23		-
Agnes Ivanovics	22	-	22		22		-
Frederic J Greenblatt	22	-	22		22		-
Jacob Berlin & Eli Berlin	22	-	22		22		-
Leon B Lipkin	22	-	22		22		-
Marline Monstein Cust FBO Jeremiah A Monstein	22	-	22		22		-
Neil Morchower	22	-	22		22		-
Richard A Monstein Cust Sean R Monstein	22	-	22		22		-
Stewart R Balikov	22	-	22		22		-
Asset Management Consultants Inc	18	-	18		18		-
Eugene Andrews	18	-	18		18		-
John Cappadora & Eleanor Cappadora	18	-	18		18		-
Margaret Tucker Cust FBO Todd Tucker	18	-	18		18		-
Kevin James Hopper	15	-	15		15		-
Albert Nicholas Casale Lo Cust FBO Alexander T Casale Lo	14	-	14		14		-

 

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	Common Shares Owned Before Sale(1)						Common Shares Owned After Sale(2)
Selling Shareholder	Held Outright	Warrants/ Options(3)	Amount		Shares being registered		Amount

Daphne Sela	14	-	14		14		-
Glenda Stone	14	-	14		14		-
Sandra Lowenstein	12	-	12		12		-
Alan Carus	11	-	11		11		-
Archie C Purvis	11	-	11		11		-
B Lee Brown & Clara J Brown	11	-	11		11		-
Linda G Mayman Cust Elisabeth Mayman	11	-	11		11		-
Stamatios Alevras & Matina Alevras	11	-	11		11		-
Thomas L Hall	11	-	11		11		-
William H Grossman & Sondra Grossman	11	-	11		11		-
Adrian W Skramstad	11	-	11		11		-
Melvin H Pressman	11	-	11		11		-
Anthony Grande & Carolyn Grande	9	-	9		9		-
Ari Rosenblatt Md	9	-	9		9		-
Brad T Anderson	9	-	9		9		-
Hugh R Martin Cust FBO Rodman Martin	9	-	9		9		-
Richard A Monstein & Marlene Monstein	9	-	9		9		-
Roger Franklin & Joan Franklin	9	-	9		9		-
Shawn M Wagmeister	9	-	9		9		-
Eddy J Heidt	7	-	7		7		-
Lana Speyer	7	-	7		7		-
Leonard Maltin	7	-	7		7		-
Michael B Lynch Cust FBO Kelly A Condon Lynch	7	-	7		7		-
Ralph Curatola	7	-	7		7		-
Robert Rub	7	-	7		7		-
Theodore H Wielandt	7	-	7		7		-
Milton Wolfson	6	-	6		6		-
Terry L Wees	6	-	6		6		-
Zila Cohen	6	-	6		6		-
Alice J Avery	5	-	5		5		-
B Frank Ricker & Esther B Ricker	5	-	5		5		-
Benjamin Zimmerman & Dina Zimmerman	5	-	5		5		-
Carol Brown	5	-	5		5		-
Charles G Martignette & Marte C Martignette	5	-	5		5		-
Debra Hanson	5	-	5		5		-
Doris Eckes Cust FBO Jeanne M Eckes	5	-	5		5		-
Edwin H Willis Cust FBO Timothy W Willis	5	-	5		5		-
Elmer M Jones	5	-	5		5		-
Frank P Marchewka & Helen Marchewka	5	-	5		5		-
Frank R Riva	5	-	5		5		-
Gary Coblens	5	-	5		5		-
George A Fellows Jr & Teresa M Fellows	5	-	5		5		-
George Johnson & Hilary Johnson	5	-	5		5		-
Helen Fishman & Sanford B Fishman	5	-	5		5		-
Hope E Briggs Ttee Hope E Briggs Tr	5	-	5		5		-
Inter/Media Time Buying Corp	5	-	5		5		-
J Chris Chris	5	-	5		5		-
John Sherman	5	-	5		5		-
Joseph Buonocore & Ada Buonocore	5	-	5		5		-
Joseph Gallo	5	-	5		5		-
Joseph R Hardiman	5	-	5		5		-
Lyman K Bridgman & Helen E Bridgman	5	-	5		5		-
Michael B Lynch	5	-	5		5		-
Milton Wolfson & Sydell Wolfson	5	-	5		5		-
Mina Wilner & Henry Wilner	5	-	5		5		-
Paul Russo & Julia Russo	5	-	5		5		-
Ralph O Lux & Marjorie T Lux	5	-	5		5		-
Rene Pauly & Martha Paula	5	-	5		5		-
Renuka Misra	5	-	5		5		-
Robert I Jackson	5	-	5		5		-
Robert T Morris & Charles I Skipsey Jr	5	-	5		5		-
Rodney Selow Van	5	-	5		5		-
Roy T Cogdell	5	-	5		5		-
Ruth Comstock	5	-	5		5		-
William J Deeb	5	-	5		5		-
William Ruben Willis	5	-	5		5		-
Bannon Loren Lomahquahu	4	-	4		4		-
Brady Baker	4	-	4		4		-
Brittni Baker	4	-	4		4		-
Clay Baker	4	-	4		4		-
Daphne M Piket	4	-	4		4		-
E F Hutton & Co Inc	4	-	4		4		-
Earl Edden Co	4	-	4		4		-
Efraim Rubinstein	4	-	4		4		-
Eli Bucksbaum	4	-	4		4		-
Frank Georgiana	4	-	4		4		-
Frederic R Stanton	4	-	4		4		-
Jacob Kelley	4	-	4		4		-
James R Hopper	4	-	4		4		-
Jessica Kelley	4	-	4		4		-
Kaci Baker	4	-	4		4		-
Laura Beth Baker	4	-	4		4		-
Max Bucksbaum	4	-	4		4		-
Michael Taliadoros	4	-	4		4		-
Otto Johnson	4	-	4		4		-
Pamela H Philyaw	4	-	4		4		-
William M Singer & Sadie Singer	4	-	4		4		-
Alex Mitchell & Stanley Mitchell	3	-	3		3		-
Alice Blackley	3	-	3		3		-
Ann Mcwilliams	3	-	3		3		-
Ansel Goldberg & Traute Goldberg	3	-	3		3		-
Anthony J Luisi	3	-	3		3		-
Anthony Marra	3	-	3		3		-
Avron Steir & Enid Steir	3	-	3		3		-
Betty Mainous	3	-	3		3		-
Cam Co	3	-	3		3		-
Charles Haravay	3	-	3		3		-
David Zoni	3	-	3		3		-
Edward Gold	3	-	3		3		-
Edward J Mccormack	3	-	3		3		-
Edward P Berzenski & Mary A Berzenski	3	-	3		3		-
Edward R Walsh	3	-	3		3		-
Edythe Reusch Fares	3	-	3		3		-
Eric M Stoller	3	-	3		3		-
Fannie Rosenberg & Lilian Kamos	3	-	3		3		-
Frances Luisi	3	-	3		3		-
George Chiulli	3	-	3		3		-
Gideon J Barness	3	-	3		3		-
Howard Hyde	3	-	3		3		-
James E Brann	3	-	3		3		-
Joesph P Thomas Di	3	-	3		3		-
John Bator & Agnes Bator	3	-	3		3		-
John J Flynn & Jeannette M Flynn	3	-	3		3		-
Joseph J Mccananagh	3	-	3		3		-
Joseph Rosati & Carmel Rosati	3	-	3		3		-
Judith Mae Bailyn Ttee Judith Mae Bailyn Tr	3	-	3		3		-
Kenneth D Cooley & Mary A Cooley	3	-	3		3		-
Manfredi & Levine Professional	3	-	3		3		-
Maura E Freeman	3	-	3		3		-
Maureen Lynch	3	-	3		3		-
Michael P Traner	3	-	3		3		-
Michael Vipiani	3	-	3		3		-
Orson Smith	3	-	3		3		-
Raymond E Anthony & Gloria M Anthony	3	-	3		3		-
Richard Monstein	3	-	3		3		-
Robert E Garst	3	-	3		3		-
Ronald A Pressman	3	-	3		3		-
Sam B Clonts	3	-	3		3		-
Sigrid B Rice	3	-	3		3		-
Sterling Grace & Co	3	-	3		3		-
Sylvia Zweibon	3	-	3		3		-
Theresa Votta	3	-	3		3		-
Vernon R Eidenire & Claire V Eidenire	3	-	3		3		-
Wilder A Johnson & Astrid Johnson	3	-	3		3		-
Anette Zoni	2	-	2		2		-
Anita Pearl Tignish	2	-	2		2		-
Ann Del Smith	2	-	2		2		-
August Scognamiglio	2	-	2		2		-
Conseco	2	-	2		2		-
David Miller	2	-	2		2		-
Derek G Fuelling	2	-	2		2		-
Douglas B Travis Cust FBO Lara C Travis	2	-	2		2		-
Edith Brand	2	-	2		2		-
Ella Wilke	2	-	2		2		-
Eve S Miller Cust FBO Peter J Miller	2	-	2		2		-
F I Dupont Glore Forgan & Co	2	-	2		2		-
Floyd T Neth	2	-	2		2		-
Gedalyahu Salamon	2	-	2		2		-
Gene Hiller & Betty Ann Hiller	2	-	2		2		-
Gerald Segel	2	-	2		2		-
Gladys M Wielandt	2	-	2		2		-
Grace O Brien	2	-	2		2		-
Henry E Engel & Margurite Engel	2	-	2		2		-
Hugh R Martin	2	-	2		2		-
Hyman Feinstein	2	-	2		2		-
Jack M Burr	2	-	2		2		-
James Dex Camak	2	-	2		2		-
James Ellis	2	-	2		2		-
James M Morgan	2	-	2		2		-
John J Crowley Cust FBO Joseph Crowley	2	-	2		2		-
Judith Zamojcin	2	-	2		2		-
Karon L Spivey	2	-	2		2		-
M Rimson & Company Inc	2	-	2		2		-
Maurice Leff	2	-	2		2		-
Michael Torres	2	-	2		2		-
Milton Friedman Cust Joel Friedman	2	-	2		2		-
Miriam Husid	2	-	2		2		-
Osma J Carnes & Minnie G Carnes	2	-	2		2		-
Philip Samuel Cadwallader	2	-	2		2		-
Richard M Bond & Carol B Bond	2	-	2		2		-
Ronald Miller	2	-	2		2		-
Ruby Share Cust FBO Karen Beth Share	2	-	2		2		-
Silene M Irving	2	-	2		2		-
Stephen Mallor	2	-	2		2		-
Virginia T Norris	2	-	2		2		-
William J Mcmahan	2	-	2		2		-
William R Norris Jr & Janet L Norris	2	-	2		2		-
William Sidney Caruthers	2	-	2		2		-
William Weatherford	2	-	2		2		-

 

40

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	Common Shares Owned Before Sale(1)						Common Shares Owned After Sale(2)
Selling Shareholder	Held Outright	Warrants/ Options(3)	Amount		Shares being registered		Amount

A C Allyn & Co	1	-	1		1		-
Abe Cohen	1	-	1		1		-
Ada Mckay Leitner	1	-	1		1		-
Adam Aislie Morgan	1	-	1		1		-
Aida L Johns	1	-	1		1		-
Albert Martinelli & Lily Martinelli	1	-	1		1		-
Aldo H Fontana	1	-	1		1		-
Alex Gee	1	-	1		1		-
Alexander F Handel & Marguerite W Handel	1	-	1		1		-
Alfred B Antonacci	1	-	1		1		-
Alfred P Vasconi & Shirley L Vasconi	1	-	1		1		-
Algis Gurinskas	1	-	1		1		-
Alice Orr Moore	1	-	1		1		-
Allen Bessen	1	-	1		1		-
Allen Glasser	1	-	1		1		-
Alonzo L Brewington	1	-	1		1		-
Alva C Roig	1	-	1		1		-
Alvin Franklin	1	-	1		1		-
Anette M Preddy	1	-	1		1		-
Anna C Lump	1	-	1		1		-
Anne Finkelstein	1	-	1		1		-
Annelle D Humphreys	1	-	1		1		-
Anthony Marle Van	1	-	1		1		-
Ara Thomasian	1	-	1		1		-
Arthur D Martin Jr	1	-	1		1		-
Arthur E Fontana	1	-	1		1		-
Bartholomew J Mccarthy	1	-	1		1		-
Bayard T Kiliani	1	-	1		1		-
Beatrice S Rokes	1	-	1		1		-
Benjamin G Cromwell	1	-	1		1		-
Benjamin Klopman & Rose Klopman	1	-	1		1		-
Benjamin Slade & Iola K Slade	1	-	1		1		-
Bernard Jaffe & Roberta Jaffe	1	-	1		1		-
Bertha Grant & Albert Grant	1	-	1		1		-
Bertna Albares	1	-	1		1		-
Betty Kennedy Cust FBO Abby H Kennedy	1	-	1		1		-
Bjarne M Olsen & Helen R Olsen	1	-	1		1		-
Borah J White Cust Phillip R White	1	-	1		1		-
Bradford H Wick & Ruth V Wick	1	-	1		1		-
Buddy Patton	1	-	1		1		-
Burton J Askowith	1	-	1		1		-
C Gregory Spangler	1	-	1		1		-
C Howard Sweatt	1	-	1		1		-
Caleb J Massee	1	-	1		1		-
Carl L Phinney	1	-	1		1		-
Carl Swanson	1	-	1		1		-
Carmen P Jordan & Carolyn J Jordan	1	-	1		1		-
Charles A Leamon	1	-	1		1		-
Charles F Wood Jr	1	-	1		1		-
Charles H Longenecker & Irene B Longenecker	1	-	1		1		-
Charles Iannacone	1	-	1		1		-
Charles J Finck	1	-	1		1		-
Charles Masten	1	-	1		1		-
Charles W Byrd	1	-	1		1		-
Charles Webb & Lillian M Webb	1	-	1		1		-
Claus A Fritzen & Dorothy Fritzen	1	-	1		1		-
Cleo B Wagoner & Vera J Wagoner	1	-	1		1		-
Collie Collins & Sandra Collins	1	-	1		1		-
Corinne B Hallemeyer	1	-	1		1		-
Corman C Smith	1	-	1		1		-
Craig A Nalen	1	-	1		1		-
Cynthia Colvin	1	-	1		1		-
D M Fowle	1	-	1		1		-
David H Densmore & Edith C Densmore	1	-	1		1		-
David J Conner	1	-	1		1		-
David M Jacobson	1	-	1		1		-
David Rosendahl	1	-	1		1		-
David S Susner & Anne Susner	1	-	1		1		-
Delafield & Delafield	1	-	1		1		-
Denise E Christman Cust FBO Celeste Edan Christman	1	-	1		1		-
Dianne Munch	1	-	1		1		-
Don Sands	1	-	1		1		-
Donald & Co	1	-	1		1		-
Donald A Oliveira & Odette Oliveira	1	-	1		1		-
Donald F Mora	1	-	1		1		-
Donald O Featherman & Susan Featherman	1	-	1		1		-
Donald S White	1	-	1		1		-
Donald W Sine &	1	-	1		1		-
Dora Crumley	1	-	1		1		-
Dorothy C Nold	1	-	1		1		-
Dorothy K Tonelli & Ruth Ankstutis	1	-	1		1		-
Douglas G Mahon Jr Cust Fbo Stephen Mahon	1	-	1		1		-
Edgar D Ross	1	-	1		1		-
Edmond F Cycler Jr & Alice C Cycler	1	-	1		1		-
Edward F Adams	1	-	1		1		-
Edward F Sturcken	1	-	1		1		-
Edward J Ober & Myrna G Ober	1	-	1		1		-
Edward P Tonelli & Dorothy K Tonelli	1	-	1		1		-
Edwin Beards Lee	1	-	1		1		-
Edwin V Tier & Lawana M Tier	1	-	1		1		-
Eleanor I Demeo	1	-	1		1		-
Elizabeth Bell	1	-	1		1		-
Elizabeth Johnson	1	-	1		1		-
Ella Blumberg	1	-	1		1		-
Ellen M Schlangen	1	-	1		1		-
Ellsworth Hoppe Cust FBO Cheryl F Hoppe	1	-	1		1		-
Emily A Mardirosian	1	-	1		1		-
Emily W Longbottom	1	-	1		1		-
Emma Freni	1	-	1		1		-
Ernest Amaral & Mary F Amaral	1	-	1		1		-
Ernest M Drucker	1	-	1		1		-
Esther Horowitz	1	-	1		1		-
Eugene Fuhrer	1	-	1		1		-
Eugene Neuman	1	-	1		1		-
Eugene Stricker & Libby Stricker	1	-	1		1		-

 

41

---

	Common Shares Owned Before Sale(1)						Common Shares Owned After Sale(2)
Selling Shareholder	Held Outright	Warrants/ Options(3)	Amount		Shares being registered		Amount

Faye Glasser	1	-	1		1		-
Foster Curry	1	-	1		1		-
Frances L Ferguson	1	-	1		1		-
Francis P Mckeon	1	-	1		1		-
Frank A Lay	1	-	1		1		-
Frank B Wise Jr & Elizabeth B Wise	1	-	1		1		-
Frank Berrell	1	-	1		1		-
Frank C Nunes Jr	1	-	1		1		-
Frank Catanzaro	1	-	1		1		-
Frank D Newman Cust FBO Frank D Newman Ii	1	-	1		1		-
Frank P Thompson	1	-	1		1		-
Frank Turone	1	-	1		1		-
Frank W Murphy	1	-	1		1		-
Frank Ziesler & Mildred Ziesler	1	-	1		1		-
Fred A Traver & Lillian A Traver	1	-	1		1		-
Fred Kosak	1	-	1		1		-
Frederick L Heller & Grace E Heller	1	-	1		1		-
Gary N Jarvela	1	-	1		1		-
Gary R Perrine & Rebecca C Perrine	1	-	1		1		-
George Andrews & Agnes Andrews	1	-	1		1		-
George E Partelow Jr	1	-	1		1		-
George F D Pridmore & Joan L Pridmore	1	-	1		1		-
George J Demetree	1	-	1		1		-
George R Kinzie Jr & Noel De Lesdernier	1	-	1		1		-
George Sarantos	1	-	1		1		-
Gerald F Reynolds	1	-	1		1		-
Giovanni Barsotti & Gina Barsotti	1	-	1		1		-
Gordon R Wright	1	-	1		1		-
Gordon Takahashi	1	-	1		1		-
Grace Scaduto	1	-	1		1		-
Guy W Botts	1	-	1		1		-
Hans J Felsch & Celina C Felsch	1	-	1		1		-
Harold Goldberg & Recia Goldberg	1	-	1		1		-
Harold Ross & Rebecca Ross	1	-	1		1		-
Harry A Kingsland & Tommy E Kingsland	1	-	1		1		-
Harry B Johnson & Phyllis M Johnson	1	-	1		1		-
Harry Macklin & Sybil Macklin	1	-	1		1		-
Harvey R Lorber	1	-	1		1		-
Harvey Wiener & Celia Wiener	1	-	1		1		-
Helen T Doyle	1	-	1		1		-
Henry B Traver Jr & Eva M Traver	1	-	1		1		-
Henry E Invester	1	-	1		1		-
Henry E Smith	1	-	1		1		-
Henry F Drews	1	-	1		1		-
Hensberry & Company	1	-	1		1		-
Herbert S Massey	1	-	1		1		-
Hilda Grant	1	-	1		1		-
Homer R Medlock Jr	1	-	1		1		-
Howard C Lotton	1	-	1		1		-
Howard L Jones	1	-	1		1		-
Irvin D Black	1	-	1		1		-
Irving Ehrlich & Sally Ehrlich	1	-	1		1		-
Irwin H Brooks & Gladys B Brooks	1	-	1		1		-
J E Harvey	1	-	1		1		-
Jack Kennedy Cust FBO Liz Kennedy	1	-	1		1		-
Jack S Crusoe	1	-	1		1		-
James Drew Gilleland	1	-	1		1		-
James Graham Chapman Jr	1	-	1		1		-
James J Duane & Co	1	-	1		1		-
James K Rush	1	-	1		1		-
James L Mcdonald & Mary W Mcdonald	1	-	1		1		-
James N Robson Jr & Cora H Robson	1	-	1		1		-
James Spaulding & Donna Spaulding	1	-	1		1		-
James W Bashan & Alfreda R Basham	1	-	1		1		-
James W Cunning	1	-	1		1		-
Jane Staly	1	-	1		1		-
Jeannette S Poel	1	-	1		1		-
Jim L Jennings	1	-	1		1		-
Joanne P Snider & Margaret Zilliax	1	-	1		1		-
Joel Michaely	1	-	1		1		-
John A Makuch	1	-	1		1		-
John D Colligan	1	-	1		1		-
John H Parker & Jeanne C Parker	1	-	1		1		-
John H Slaughter	1	-	1		1		-
John L Dickson & Jean A Dickson	1	-	1		1		-
John P Shewman	1	-	1		1		-
John W Prichard	1	-	1		1		-
John W Trevethan	1	-	1		1		-
John Yelvington	1	-	1		1		-
Joseph Barcikai	1	-	1		1		-
Joseph S Vecchione	1	-	1		1		-
Judith A W Wawro	1	-	1		1		-
Judith Schneider & Sheldon Schneider	1	-	1		1		-

 

42

---

	Common Shares Owned Before Sale(1)						Common Shares Owned After Sale(2)
Selling Shareholder	Held Outright	Warrants/ Options(3)	Amount		Shares being registered		Amount

Kathleen K Phillips	1	-	1		1		-
Kay S Ranches Inc	1	-	1		1		-
Kenneth A Goerke & Sally Goerke	1	-	1		1		-
Kenneth C Wittich & Clara A Wittich	1	-	1		1		-
Kenneth G Ketchum & Anita M Ketchum	1	-	1		1		-
Kenneth J Fullerton	1	-	1		1		-
Kenneth L Menown	1	-	1		1		-
Kevin F Cunningham	1	-	1		1		-
La Verne Stone Cust FBO Keith J Stone	1	-	1		1		-
Laird Bissell & Meeds Inc	1	-	1		1		-
Lassor H Grosberg	1	-	1		1		-
Lathrop B Flintom Jr	1	-	1		1		-
Leba Rae Mccoy	1	-	1		1		-
Leba Ray Mccoy & Robert S Gold	1	-	1		1		-
Leo H Zindler Jr	1	-	1		1		-
Leon R Cardwell	1	-	1		1		-
Leona M Malphurs	1	-	1		1		-
Leonard N Klein & Florence C Klein	1	-	1		1		-
Leone & Pollack	1	-	1		1		-
Leroy Hallman	1	-	1		1		-
Loene J Stoer	1	-	1		1		-
Louis C Miller & Gwendolyn E Miller	1	-	1		1		-
Louis Guillerme Cust FBO Allan Jacques Guillerme	1	-	1		1		-
Louise M Clements	1	-	1		1		-
Lucy Pepe	1	-	1		1		-
M Doris Leibold Cust FBO Jean Ellen Leibold	1	-	1		1		-
M Josephine Dawson	1	-	1		1		-
M S Wien & Co	1	-	1		1		-
Madge Wilson	1	-	1		1		-
Manola Miranda	1	-	1		1		-
Margaret E Lyons	1	-	1		1		-
Margaret J Becker	1	-	1		1		-
Margo Simpson	1	-	1		1		-
Maria Montanino	1	-	1		1		-
Marie L Ebbitt	1	-	1		1		-
Marie P Salvini & Emil R Salvini	1	-	1		1		-
Mark Renneker	1	-	1		1		-
Marlene G Hamilton	1	-	1		1		-
Martin Karasick	1	-	1		1		-
Mary C Logue	1	-	1		1		-
Mary Lena Faulk	1	-	1		1		-
Maureen Grady	1	-	1		1		-
Maurice Deutsch & Harriet Deutsch	1	-	1		1		-
May C Edwards & Carol May Edwards	1	-	1		1		-
Meredith M Amphlett & Mary M Amphlett	1	-	1		1		-
Merle L Long	1	-	1		1		-
Michael E Gorman	1	-	1		1		-
Michael Pfundstein & Hilda H Pfundstein	1	-	1		1		-
Michael Renneker	1	-	1		1		-
Miguel Regaldo	1	-	1		1		-
Mildred S Montgomery	1	-	1		1		-
Milton J Pearl	1	-	1		1		-
Miriam H Epps Van	1	-	1		1		-
Mizpah G Albury	1	-	1		1		-
Morris H Furay & Agnes E Furay	1	-	1		1		-
Nancy B Howard	1	-	1		1		-
Nancy Gaines Goff	1	-	1		1		-
NCC & Co	1	-	1		1		-
Nicholas S Pazar	1	-	1		1		-
Nick Sacco	1	-	1		1		-
Noah Griver Cust FBO David Allen Griver	1	-	1		1		-
Oram Kerr	1	-	1		1		-
Orlen D Kepler & Waneta L Kepler	1	-	1		1		-
Oscar Wohl	1	-	1		1		-

 

 

43

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	Common Shares Owned Before Sale(1)						Common Shares Owned After Sale(2)
Selling Shareholder	Held Outright	Warrants/ Options(3)	Amount		Shares being registered		Amount

Parts Service Corporation	1	-	1		1		-
Paul Hanzlik & Frances Hanzlik	1	-	1		1		-
Paul Vincent Kennedy & Sylvia A Kennedy	1	-	1		1		-
Pauline Maslynsky	1	-	1		1		-
Pearl Meppen Drabkin & Bernice Meppen Susskind	1	-	1		1		-
Peter Lowden & Grace Lowden	1	-	1		1		-
Peter P Rana & Lola I Rana	1	-	1		1		-
Philip Schless	1	-	1		1		-
Pierre L Steward	1	-	1		1		-
Poo Quong Chin	1	-	1		1		-
Ralph H Jensen	1	-	1		1		-
Ralph Ragonese	1	-	1		1		-
Ray R Poynter Jr & Mary Gleason	1	-	1		1		-
Rex Estorffe	1	-	1		1		-
Richard B Vavra	1	-	1		1		-
Richard F Dalton	1	-	1		1		-
Richard Guttler	1	-	1		1		-
Richard L Lehmann	1	-	1		1		-
Richard P Myers	1	-	1		1		-
Richard S Berger & Shelia Berger	1	-	1		1		-
Richard W Morris	1	-	1		1		-
Richardt-Alyn & Co	1	-	1		1		-
Robert A Craig	1	-	1		1		-
Robert A Sims	1	-	1		1		-
Robert Block & Hinda Block	1	-	1		1		-
Robert C May & Betty J May	1	-	1		1		-
Robert C Whitehead Jr	1	-	1		1		-
Robert G Covel Jr	1	-	1		1		-
Robert H Jenkins & E Nelda Jenkins	1	-	1		1		-
Robert H Woodward Cust FBO Carol Ann Woodward	1	-	1		1		-
Robert J Bell	1	-	1		1		-
Robert J Bishop	1	-	1		1		-
Robert M Jugan & Sandra Jugan	1	-	1		1		-
Robert P Grady	1	-	1		1		-
Robert P Mosier & Ray T Ensor	1	-	1		1		-
Robert R Lowe	1	-	1		1		-
Robert R Smith	1	-	1		1		-
Robert W Barker & Dorothy Josephine Barker	1	-	1		1		-
Roscoe Johnson	1	-	1		1		-
Rose Pietro Di	1	-	1		1		-
Rosina Entrement Md	1	-	1		1		-
Roslynne D Bloom	1	-	1		1		-
Roy D Baldwin & Jane A Baldwin	1	-	1		1		-
Roy T Hawk & Elizabeth L Hawk	1	-	1		1		-
Royer Securities Company	1	-	1		1		-
Rupert E Dunkum Jr	1	-	1		1		-
Rupert E Dunkum Jr Cust FBO Laura Maxine Dunkum	1	-	1		1		-
Russell & Sake	1	-	1		1		-
S A Welch	1	-	1		1		-
Sara Ann Rydstrom	1	-	1		1		-
Shearson Hammil & Co Inc	1	-	1		1		-
Sheldon Gordel	1	-	1		1		-
Shirley G Inman Cust FBO Scott D Inman	1	-	1		1		-
Sophia Koslow	1	-	1		1		-
Stafford C Delesdernier	1	-	1		1		-
Stanley C Thomas & Doris Brooks	1	-	1		1		-
Stanley Kasper & Mary L Kasper	1	-	1		1		-
Stanley Zuppke & Alice G Zuppke	1	-	1		1		-
Stephen Savino	1	-	1		1		-
Sue Oldham Cheney	1	-	1		1		-
Suzanne K Jones	1	-	1		1		-
Syd Polansky & Arnold Polansky	1	-	1		1		-
Sydney M Jaffe & Rita D Jaffe	1	-	1		1		-
T Lee Terry	1	-	1		1		-
Therese Lynch & Claude J Lynch	1	-	1		1		-
Thomas J Haydon & Velma M Haydon	1	-	1		1		-
Thomas K Hickman	1	-	1		1		-
Thomas N Canning & Norma E Canning	1	-	1		1		-
Thomas W Sullivan	1	-	1		1		-
Titusville Elks Lodge	1	-	1		1		-
Tom W Westing	1	-	1		1		-

44

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	Common Shares Owned Before Sale(1)						Common Shares Owned After Sale(2)
Selling Shareholder	Held Outright	Warrants/ Options(3)	Amount		Shares being registered		Amount

Vahak Gadarian & Aza Gadarian	1	-	1		1		-
Verdery A Clark	1	-	1		1		-
Victor J Connor & Maureen Connor	1	-	1		1		-
Victor Seaberg & Lucy S Seaberg	1	-	1		1		-
Virginia A Burr Cust FBO Bonnie Sue Burr	1	-	1		1		-
Walter D Griffin & Constance C Griffin	1	-	1		1		-
Walter G Giblin	1	-	1		1		-
Walter Hudzik	1	-	1		1		-
Walter Waligunda	1	-	1		1		-
Wanda Ashe	1	-	1		1		-
Wayne R Collins	1	-	1		1		-
Wego & Co	1	-	1		1		-
Weigerco	1	-	1		1		-
Wilfred Desilets	1	-	1		1		-
William A Dobson Jr & Frances Dobson	1	-	1		1		-
William A Robertson & Nancy Robertson	1	-	1		1		-
William A Swartman	1	-	1		1		-
William B Holmes	1	-	1		1		-
William D Gorman & Harriet W Gorman	1	-	1		1		-
William E Griess Jr	1	-	1		1		-
William F Mount	1	-	1		1		-
William G Moller	1	-	1		1		-
William H Reynolds & Ann Jane Reynolds	1	-	1		1		-
William J Davis	1	-	1		1		-
William Jerchau	1	-	1		1		-
William L Garrott	1	-	1		1		-
William M Burr	1	-	1		1		-
William P Murchison Cust FBO Robert B Hunt	1	-	1		1		-
William R Overfield	1	-	1		1		-
William Strauss Cust FBO Barry Strauss	1	-	1		1		-
William T Sacco	1	-	1		1		-
William W Bauer	1	-	1		1		-
William W Heath	1	-	1		1		-
Winifred D Mawhood Ross	1	-	1		1		-
Woodrow W Strickland	1	-	1		1		-
Zack Crumpton & Helen C Crumpton	1	-	1		1		-
Unknown(11)	71,759	-	71,759		71,759		-
Total	500,361		500,361		500,361

REGISTRATION RIGHTS

The holders of 5,016,667 shares of our common stock and the holders of 8,146,667 shares of our common stock issuable upon exercise of warrants and options are entitled to rights with respect to the registration of their shares under the Securities Act of 1933. We are also registering an additional 100,000 common shares which we may become obligated to issue in the event we incur additional penalties pursuant to our registration rights agreements. These registration rights are contained in the registration rights agreements entered into with certain investors as well as embedded in agreements detailing the holders' rights under their individually granted warrants and options. In addition to the common shares to be registered pursuant to the registration rights agreement, we are also voluntarily registering 3,072,000 common shares and common shares issuable upon the exercise of certain options and warrants issued to our investors, consultants and advisors.

From January 8 through March 8 2006, we raised $5,000,000 in gross proceeds from the private placement of units consisting of one share of common stock, ½ class “A” warrant, and ½ class “B” warrant, to 64 investors. The offering was effected through T.R. Winston & Company, a registered broker-dealer, as placement agent, pursuant to which we sold:

 

·	5,000,000 common shares;

 

·	2,500,000 class 'A' warrants, each warrant entitling the holder to purchase one share of common stock for $1.50; and

 

·	2,500,000 class 'B' warrants, each warrant entitling the holder to purchase one share of common stock for $2.00;

F-5

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Note 1. Nature of Business and Significant Accounting Policies

 

Nature of business:

Neuralstem, Inc. (“Company”) is a biopharmaceuticals company that is utilizing its proprietary human neural stem cell technology to create a comprehensive platform for the treatment of central nervous system diseases. The Company will commercialize this technology as a tool for use in the next generation of small-molecule drug discovery and to create cell therapy biotherapeutics to treat central nervous system diseases for which there are no cures. The Company was founded in 1996, incorporated in 1997, and currently occupies lab and office space in Gaithersburg, Maryland.

Inherent in the Company's business are various risks and uncertainties, including its limited operating history, the fact that Neuralstem's technologies are new and may not allow the Company or its customers to develop commercial products, regulatory requirements associated with drug development efforts and the intense competition in the genomics industry. The Company's success depends, in part, upon successfully raising additional capital, prospective product development efforts, the acceptance of the Company's solutions by the marketplace, and approval of the Company's solutions by various governmental agencies.

The Company has incurred cumulative losses of approximately $35,445,238 since inception and reported a net loss of approximately $1,651,507 for the year ended December 31, 2005. In order to further its research and develop its products, the Company will require additional financing until such time that revenue streams are of sufficient volume to generate positive cash flow from operations. Possible sources of funds are strategic alliances, additional equity offerings, grants and contracts, and research and development funding from third parties. Management intends to raise additional capital and remains committed to taking all appropriate and necessary actions to effect timely cost reductions and cash preservation measures in the event anticipated revenue and cash flow expectations are not substantially met. Subsequent to December 31, 2005, the Company had raised $4,550,000 in equity funding (see Note 8).

A summary of the Company's significant accounting policies is as follows:

Estimates

The preparation of financial statements in conformity with generally accepted accounting principles requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements and the reported amounts of revenues and expenses during the reporting period. Actual results could differ from those estimates.

Cash and Equivalents

For the Statements of Cash Flows, all highly liquid investments with maturity of three months or less are considered to be cash equivalents. There were no cash equivalents as of December 31, 2005 and December 31, 2004.

 

F-6

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Note 1.  Nature of Business and Significant Accounting Policies (continued)

 

Property and Equipment

Property and equipment is stated at cost and depreciated on a straight-line basis over the estimated useful lives ranging from three to seven years. Expenditures for maintenance and repairs are charged to operations as incurred.

Recoverability of Long-Lived Assets and Identifiable Intangible Assets

Long-lived assets and certain identifiable intangible assets to be held and used are reviewed for impairment when events or changes in circumstances indicate that the carrying amount of such assets may not be recoverable. Determination of recoverability is based on an estimate of undiscounted future cash flows resulting from the use of the asset and its eventual disposition. In the event that such cash flows are not expected to be sufficient to recover the carrying amount of the assets, the assets are written down to their estimated fair values. Long-lived assets and certain identifiable intangible assets to be disposed of are reported at the lower of carrying amount or fair value less cost to sell.

Fair Value of Financial Instruments

The fair values of financial instruments are estimated based on market rates based upon certain market assumptions and information available to management. The respective carrying value of certain on-balance-sheet financial instruments approximated their fair values. These financial instruments include cash, accounts payable and notes payable. Fair values were assumed to approximate carrying values for cash and payables due to the short-term nature or that they are payable on demand.

Revenue Recognition

To date, revenue has been derived primarily from providing treated samples for gene expression data from stem cell experiments and from providing services under a federal grant program sponsored by the Defense Advanced Research Projects Agency (DARPA) $70,000 and $125,000 in 2005 and 2004, respectively. Revenue is recognized when there is persuasive evidence that an arrangement exists, delivery of goods and services has occurred, the price is fixed and determinable, and collection is reasonably assured.

Research and Development

Research and development costs are charged to operations when incurred.

 

 

F-7

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Note 1.  Nature of Business and Significant Accounting Policies (continued)

 

Income taxes

Income taxes are provided for using the liability method of accounting in accordance with SFAS No. 109“Accounting for Income Taxes.” A deferred tax asset or liability is recorded for all temporary differences between financial and tax reporting. Temporary differences are the differences between the reported amounts of assets and liabilities and their tax basis. Deferred tax assets are reduced by a valuation allowance when, in the opinion of management, it is more likely than not that some portion or all of the deferred tax assets will not be realized. Deferred tax assets and liabilities are adjusted for the effect of changes in tax laws and rates on the date of enactment.

Stock - Based Compensation

The Company recognizes expenses for stock-based compensation arrangements in accordance with provisions of Accounting Principles Board (APB) Opinion No. 25, “ Accounting for Stock Issued to Employees,” and related Interpretations. Accordingly, compensation cost is recognized for the excess of the estimated fair value of the stock at the grant date over the exercise price, if any. The Company accounts for equity instruments issued to non-employees in accordance with EITF 96-18,“Accounting for Equity Instruments that are Issued to Other Than Employees for Acquiring, or in Conjunction with Selling Good or Services.” Accordingly, the estimated fair value of the equity instrument is recorded on the earlier of the performance commitment date or the date the services required are completed.

 

The FASB issued SFAS No.148, "Accounting for Stock-Based Compensation - Transition and Disclosure." This statement amends SFAS No.123, "Accounting for Stock-Based Compensation," to provide alternative methods of transition for a voluntary change to the fair value-based method of accounting for stock-based employee compensation. Pursuant to SFAS No.123, the Company would expense the fair market value of stock options newly granted to third parties and disclose the pro forma results based on the fair value of options/warrants granted to employees.

No stock-based employee compensation cost is reflected in net income, as all options granted to employees had an exercise price equal to the market value of the underlying common stock on the date of grant. The following table illustrates the effect on net income and earnings per share if the Company had applied the fair value recognition provisions of FASB Statement No. 123, Accounting for Stock-Based Compensation, to stock-based employee compensation.

		2005			2004
Net loss, as reported		$	(1,651,507	)	$	(9,376,543	)
Add: total stock-based compensation as
determined under SFAS 123			(147,605	)		-
Pro forma net loss		$	(1,799,112	)	$	(9,376,543	)
Basic loss per share:
As reported		$	(0.16	)	$	(4.65	)
Pro forma		$	(0.17	)	$	(4.65	)

 

Comprehensive Loss

Statement of Financial Accounting Standard (SFAS) No. 130“Reporting Comprehensive Income,” requires the presentation of comprehensive income or loss and its components as part of the financial statements. For the years ended December 31, 2005 and 2004, the Company's net loss reflects comprehensive loss and, accordingly, no additional disclosure is required.

 

Recent Accounting Pronouncements

 

In November 2004, the FASB issued SFAS No. 151, “Inventory Costs, an amendment of Accounting Research Bulletin No. 43, Chapter 4” (“SFAS No. 151”). SFAS No. 151 requires that abnormal amounts of idle facility expense, freight, handling costs and wasted materials (spoilage) be recorded as current period charges and that the allocation of fixed production overheads to inventory be based on the normal capacity of the production facilities. SFAS No. 151 becomes effective for our Company on January 1, 2006. The Company does not believe that the adoption of SFAS No. 151 will have a material impact on our financial statements.

 

F-8

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Note 1.  Nature of Business and Significant Accounting Policies (continued)

 

In December 2004, the FASB issued SFAS No. 123 (revised 2004), “Share-Based Payment.” SFAS No. 123R replaced SFAS No. 123 and superseded Accounting Principles Board Opinion No. 25. SFAS No. 123R will require compensation costs related to share-based payment transactions to be recognized in the financial statements. On April 14, 2005, the Securities and Exchange Commission issued an announcement amending the compliance dates for the FASB's SFAS 123R that addresses accounting for equity based compensation arrangements. Under SFAS 123R registrants would have been required to implement the standard as of the beginning of the first interim or annual period that begins after June 15, 2005. The Commission's new rule will allow companies to implement SFAS 123R at the beginning of the next fiscal year after June 15, 2005. The Company anticipates adopting SFAS 123R in the first quarter 2006. The Company does not believe that the adoption of SFAS No. 123R will have a material impact on our financial statements.

 

In December 2004, the FASB issued SFAS No. 153, “Exchanges of Nonmonetary Assets, an amendment of APB Opinion No. 29” (“SFAS No. 153”). SFAS No. 153 is based on the principle that exchanges of nonmonetary assets should be measured based on the fair value of the assets exchanged. APB Opinion No. 29, “Accounting for Nonmonetary Transactions,” provided an exception to its basic measurement principle (fair value) for exchanges of similar productive assets. Under APB Opinion No. 29, an exchange of a productive asset for a similar productive asset was based on the recorded amount of the asset relinquished. SFAS No. 153 eliminates this exception and replaces it with an exception of exchanges of nonmonetary assets that do not have commercial substance. SFAS No. 153 became effective for our Company as of July 1, 2005. The Company will apply the requirements of SFAS No. 153 on any future nonmonetary exchange transactions.

In March 2005, the FASB issued FASB Interpretation ("FIN") No. 47 "Accounting for Conditional Asset Retirement Obligations--an Interpretation of FASB Statement No. 143" ("FIN No. 47"). FIN No. 47 clarifies the timing of liability recognition for legal obligations associated with the retirement of a tangible long-lived asset when the timing and/or method of settlement are conditional on a future event. FIN No. 47 is effective for us no later than December 31, 2005. We do not expect that the adoption of FIN No. 47 will have a material impact on our financial condition or results of operations.

In May 2005,  the FASB issued SFAS No. 154, “Accounting Changes and Error Corrections, a replacement of APB No. 20 and FASB Statement No. 3” (“SFAS No. 154”).  SFAS No. 154 requires retrospective application to prior periods' financial statements of a voluntary change in accounting principle unless it is impracticable.  APB Opinion No. 20 “Accounting Changes,” previously required that most voluntary changes in accounting principle be recognized by including in net income of the period of the change the cumulative effect of changing to the new accounting principle.  This statement is effective for our Company as of January 1, 2006. The Company does not believe that the adoption of SFAS No. 154 will have a material impact on our financial statements.

 

F-9

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Note 2.  Stockholders' Deficit

 

Common stock

The authorized stock of the Company consists of 7,000,000 shares of preferred stock with a par value of $0.01 and 75,000,000 shares of common stock with par value of $0.01. The preferred stock is divided into A, B, and C Series.

In November 2004, the Company effectuated a reverse stock split, where three (3) shares of common stock were issued for every ten (10) shares of common stock previously owned. The prior information has been adjusted to reflect the reverse stock split. In conjunction with the conversion of the preferred stock, the Company amended the Articles of Incorporation to authorize 75,000,000 shares of common stock, without reauthorization of the preferred shares.

During the year ended December 31, 2005, the Company sold 2,246,000 shares of common stock for a total consideration of $1,123,000 or $0.50 per share. In conjunction with the sale of these shares, the Company issued 1,845,287 shares of common stock and warrants for 1,000,000 shares of common stock with an exercise price of $5.00 per for services performed related to capital raised. The 1,845,287 shares and related warrants have been treated as an offering expense and have been netted against the total proceeds raised of $1,123,000.

Preferred Series A & B Stock

The Company issued 1,047,588 shares of Series A Preferred Stock and 719,895 shares of Series B Preferred Stock as of December 31, 2005 and 2004. The holders of the Series A and B Preferred Stock are entitled to noncumulative dividends of 8% per annum, on the original issue price of $7.64 per share, when and if declared by the board of directors. The preferred stockholders have a liquidation preference above all other classes of stock equal to $7.64 per share plus all declared and unpaid dividends. The liquidation price per share is subject to adjustment for certain dilutive events, as defined.

At any time, a preferred stockholder has the option to convert their shares into shares of common stock on a basis of 1 preferred shares for 0.3 common share. The conversion rate is subject to adjustment for certain dilutive events, as defined. Shares of Series A & B Preferred Stock automatically converts into common stock upon the closing of an underwritten public offering in which the Company's per share price is at least $3.00 and the gross proceeds to the Company exceed $7.5 million or upon the election of a majority of the preferred stockholders.

The preferred stockholders are entitled to the number of votes that equals the number of shares of common stock into which such shares could be converted, as defined. The vote or written consent of the majority of the preferred stockholders is required to (i) effect of validate a change in the authorized number of shares of preferred; (ii) a redeem, repurchase, pay dividends or make any other distribution to common stockholders; or (iii) effect any action resulting in the payment or declaration of dividends on any class of stock.

 

 

F-10

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Note 2.  Stockholders' Deficit (continued)

 

Preferred Series C Shares

During 2003, the Company issued 504,694 Series C Preferred Stock at $1.60 per share. Each share of Series C Preferred Stock is convertible to 3 shares of common stock. Stock issuance costs of $27,506 were offset against the additional paid in capital from the sale of stock.

On October 6, 2003, the Company issued “Option Promissory Notes” (Notes) totaling $605,000. The Notes are convertible to Series C Preferred Stock at the same terms and conditions as the Series C Preferred Stock outstanding on the effective date of the Notes, at any time before the Due Date, in lieu of cash repayment. The current terms are to convert the Notes at $1.60 per share of Series C Preferred Stock.

Additionally, the Notes granted the holder the option to acquire their pro rata share, based on the principal balance of the Note as a percentage of the Aggregate Note, if any, of up to $5 million of equity in Neuralstem, Inc. under the same terms and conditions as the Series C Preferred Stock of an exercise price of $1.60 per share on or before October 6, 2008 (the Option). The price per share of the equity to be purchased under the Option shall increase by 10% on every six month anniversary starting after April 6, 2004. The option may be exercised in whole or in part at any time during the period between the date of the Note and the expiration date of the Option at the Holder's discretion. The options were valued using the Black-Scholes model for option valuation. The assumptions used in arriving at the fair value of these options under the Black-Scholes option pricing model include stock price of $1.60 at the date of grant; expected life of 1 year; volatility of 134%; and discount rate of 4.29%. The $5 million of equity equates to 3,125,000 shares of Series C Preferred Stock. A beneficial conversion feature of the Notes of $2,539,004 was recorded to additional paid in capital on October 6, 2003. Beneficial conversion feature results from the allocation of proceeds to the options and the effective conversion rate of the notes being below the fair value of the Series C Preferred Stock. Interest expense of $10,577 was recorded for the period ended December 31, 2003. The entire beneficial conversion feature was expensed as interest expense in November 2004, as the convertible debt was converted to Preferred Series C shares.

In October 2004, the Company issued additional Notes to officers of the Company in lieu of $479,988 in accrued salary and consulting fees. The new Notes had the same terms and conditions and Options as the Notes issued in 2003 which included the option to acquire their pro rata share of the 3,125,000 shares of the Series C Preferred Stock. The Options for the Notes issued in 2004 were also valued using the Black-Scholes model. The assumptions used in arriving at the fair value of these options under the Black-Scholes option pricing model include stock price of $1.60 at the date of grant; expected life of 1 year; volatility of 1%; and discount rate of 4.29%. The pro-rata portion of the $5 million, 1,093,480 shares of the 3,125,000 are allocated to the new Notes. The beneficial conversion feature allocated to these Notes recorded $270,831 to additional paid in capital on October 25, 2004. This conversion feature was converted to interest expense in November 2004, as the convertible debt was converted to Preferred Series C shares.

In November 2004, the Board of Directors approved the conversion of all Notes to Series C Preferred Stock. In consideration of monthly accrued interest on the Notes and as an incentive for the noteholders to convert the Notes into Series C Preferred Stock, the Company agreed to issue the shares offered in the Option totaling 3,125,000, without consideration which the Company recorded deemed interest expense of $5,000,000 equal to what would otherwise should have been received in cash by the Company if it had not forego the exercise price of such Options. It is the Company’s management belief that its decision to forego the cash consideration related to the exercise price of such Options induced the noteholders in converting such Notes to Series C Preferred Stock. The business purpose of us offering the inducement was; (i) to decrease our liabilities in order to facilitate our ability to raise capital; and (ii) to avoid any possible default on the notes as we did not have sufficient cash to repay the notes.

F-11

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Note 2. Stockholders' Deficit (continued)

 

Preferred shares were allocated as follows:

 

			Preferred			Conversion Factor			Common
Series A			1,047,588			1-for-0.3			314,276
Series B			719,895			1-for-0.3			215,969
Series C			4,550,718			1-for-3			13,652,154
			6,318,201						14,182,399

 

In 2005, the shareholders of preferred series A, B and C, totaling 6,298,562 shares were converted into 14,182,399 shares of common stock. As of December 31, 2005, there were no outstanding preferred shares.

Stock Options

In 1997, the Company adopted a stock incentive plan (the Plan) to provide for the granting of stock awards, such as stock options and restricted common stock to employees, directors and other individuals as determined by the Board of Directors. The Company reserved 2.7 million shares of common stock for issuance under the Plan. At December 31, 2002, 816,084 options were outstanding with 216,040 options exercisable. During 2003, the Company reduced operations and terminated employment with all employees. The Plan was discontinued, terminating all options outstanding.

In July 2005, the Company granted options for 2,400,000 shares of common stock to two of its officers with an exercise price of $0.50 vesting annually on the anniversary grant date over a four year period with a ten year life which non were vested as of December 31, 2005. The fair value of these options under the Black-Scholes option pricing model totaled $0.49 per share. The assumptions used in arriving at the fair value of these options under the Black-Scholes option pricing model include stock price of $0.50 at the date of grant; expected life of 5.5 years; volatility of 224%; and discount rate of 4.1%.

Stock Warrants

During the year ended December 31, 2005, the Company issued warrants to various consultants for 1,599,000 shares of common stock with an exercise price ranging from  $0.05 to $2.00 per share with expirations from 2007 to 2017. The warrants were issued for consulting services performed which had been valued at approximately $660,000 and expensed for the year ended December 31, 2005. The warrants were valued using the Black Scholes option pricing model based on the following assumptions: stock price of at date of issuance of $0.50; expected life of 1.5 years; volatility rate of 224%; and discount rate of 4.1%.

 

 

F-12

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Note 2. Stockholders' Deficit (continued)

During the year ended December 31, 2005, the Company issued warrants for 200,000 shares of common stock with an exercise price of $0.50 expiring in 2008 related to a note payable. The warrants were issued related to a note payable which had been valued at approximately $84,000 and was deemed as interest expense for the year ended December 31, 2005. The options were valued using the Black Scholes option pricing model based on the following assumptions: stock price of at date of issuance of $0.50; expected life of 2 years; volatility rate of 224%; and discount rate of 4.1%.

Warrants to purchase common stock were issued to certain stockholders and consultants.

 

The following table summarizes information about stock warrants at December 31, 2005 which all are currently exercisable:

   

Exercise Price			Outstanding Warrants			Expiration Date
$10.00			100,000			2006
$ 0.50			1,000,000			2007
$ 0.50			320,000			2008
$ 0.50			330,000			2010
$ 0.05			49,000			2017
$ 2.00			100,000			2016
$ 5.00			1,000,000			2016

Net loss per common share

Net loss per share is calculated in accordance with SFAS No. 128, “Earnings Per Share.” The weighted-average number of common shares outstanding during each period is used to compute basic loss per share. Diluted loss per share is computed using the weighted averaged number of shares and dilutive potential common shares outstanding. Dilutive potential common shares are additional common shares assumed to be exercised. Dilutive loss per share is excluded from the calculation because the effect would be anti-dilutive.

Common stock payable for 226,000 unissued shares of common stock

During the year ending December 31, 2005, the Company received $113,000 for 226,000 shares of its common stock. As of December 31, 2005, the Company had not issued any of the 226,000 shares of common stock. However, the 226,000 unissued shares of common stock have been included in the net loss per share computation in the accompanying statement of operations. The Company was not able to issue these shares as of December 31, 2005 but anticipates issuing these unissued shares in 2006.

 

Note 3.  Property and Equipment

 

The major classes of property and equipment consist of the following:

		2005			2004
Computers and office equipment		$	301,892		$	300,053
Lab equipment			524,336			507,836
		$	826,228		$	807,889
Less accumulated depreciation and amortization			(797,090	)		(746,820	)
Property and equipment, net		$	29,138		$	61,069

 

Depreciation expense for the years ended December 31, 2005 and 2004 was $50,270 and $153,800, respectively. During year ended December 31, 2004, the Company sold certain lab equipment which resulted in a loss totaling $842, 719 and has been reflected in the accompanying statements of operation within nonoperating income (loss).

 

F-13

---

 

Note 4.  Intangible Assets

 

The Company holds patents related to its stem cell research. Patent filing costs were capitalized and are being amortized over the life of the patents. The company has determined that the intangibles purchased have a seventeen year useful life. The provisions of SFAS No. 142“Goodwill and Other Intangible Assets”  require the completion of an annual impairment test with any impairments recognized in current earnings. The Company determined that no impairment to the assigned values had occurred. The Company's intangible assets and accumulated amortization consisted of the following at December 31, 2005 and 2004:

 

		2005						2004
			Gross			Accumulated Amortization			Gross			Accumulated Amortization
Patent filing fees		$	24,796		$	(10,469	)	$	24,796		$	(8,816	)

 

Amortization expense for the years ended December 31, 2005 and 2004 was $1,653 and $1,755, respectively.

 

Note 5.  Notes payable

 

As described in Note 2, on October 6, 2003, the Company issued “Option Promissory Notes” (Notes) totaling $605,000, convertible to Series C Preferred Stock. The Notes carry a stated interest rate of 5%, payable quarterly beginning January 1, 2004. Fifty percent of the principal was due on October 3, 2004 and fifty percent due on October 3, 2005. The shares were converted to Series C Preferred Stock in November 2004, without payments of principal or interest on the Notes. As of December 31, 2005, the Note was fully paid.

In April 2005, the Company received a notice from the Department of Economic Development (“DED”) from the County of Montgomery, Alabama whereby provisions of a $40,000 grant received in 2001 were not fully satisfied. As a result, the Company was required to return the grant. In 2004, the Company recorded an accrued liability for this amount. In 2005, the Company reclassified the accrued liability as a note payable since the notice from DED provided provisions for the grant funds to be returned over a five year period, in monthly payments of both principal and interest, interest rate of 5% and maturing in May 2010. As of December 31, 2005, the balance related to this note totaled $37,341.

In November 2001, the Company entered into an agreement with a bank to borrow $625,000. The note was renegotiated in May 2002 to require principal payments of $25,000 per month beginning August 2002 and to accrue interest at the prime rate plus 1.5% with the balance of principal and accrued interest due on December 9, 2002. The note was renegotiated in December 2002 to require principal payments of $25,000 per month through February 2003, increasing to $40,000 per month starting March 2003, and to accrue interest at the prime rate plus 1.5% with the balance of principal and accrued interest due on June 20, 2003. Substantially all of the Company's assets provide collateral for the borrowings. As of December 31, 2005 and 2004, the balance related to this note totaled $116,255 and $118,000, respectively. The note was paid in 2006, see Note 8.

 

F-14

---

 

Note 5.  Notes payable (continued)

 

As of December 31, 2004, a stockholder's note payable totaling $60,000 was unsecured, bearing no interest and due on demand. In January 2005, the Company satisfied full payment of this note with 120,000 shares of its common stock at $0.50 per share.

Notes payable at December 31, 2005 and 2004 are as follows:

 

		2005			2004
Note payable to Bank, interest at prime rate plus $1.5%, due June 20, 2003, collateralized by all assets of the Company and guaranteed by an officer of the Company		$	116,255		$	118,000
Note payable, stockholder			-			60,000
Note payable			37,341			-
			153,596			178,000
Current portion of note payable			(125,201	)		118,000
Long-term portion of note payable		$	28,395		$	60,000

 

Note 6.  Income Taxes

 

We did not provide any current or deferred U.S. federal income tax provision or benefit for any of the periods presented because we have experienced operating losses since inception. We provided a full valuation allowance on the net deferred tax asset, consisting of net operating loss carryforwards, because management has determined that it is more likely than not that we will not earn income sufficient to realize the deferred tax assets during the carryforward period.

 

The tax effects (computed at a 35% effective tax rate) of significant temporary differences representing deferred tax assets for December 31, 2005 and 2004 are as follows:

 

		2005			2004
Deferred tax assets:
Net operating loss carryforward		$	8,425,356		$	8,118,339
Research and development			361,860			361,860
Start-up costs			6,276			8,368
Depreciation			30,092			30,092
Stock Compensation Expense			450,318			2,697,778
Deferred liabilities			47,532			47,532
Other			140,328			139,003
Deferred tax liabilities			9,461,762			11,402,972
Net deferred tax assets			-			-
Valuation allowance			(9,461,762	)		(11,402,972	)
Net deferred tax asset		$	0		$	0

F-15

---

 

At December 31, 2005, the Company has net operating loss carryforward of approximately $24.1 million. The Company has also reported certain other tax credits, the benefit of which has been deferred. The Company's NOL carryforward and credits will begin to expire in the tax year 2012. The timing and manner in which these net operating loss carryforward and credits may be utilized in any year by the Company will be limited to the Company's ability to generate future earning and also may be limited by certain provision of the U.S. tax code.

 

Note 7.  Commitments and Contingencies

In February 2004, the Company entered into a new license agreement (lease) for facilities in Montgomery County Maryland. The term of the license agreement is effective from March 1, 2004 through January 31, 2005. The Company has an option to request renewal of the license for two (2) additional terms of one year each.

The monthly payments for the agreement are for $3,530 per month for the initial term of the agreement. The two renewal terms have monthly payments of $4,271.

On November 1, 2005, the Company amended and extended its employment agreements dated January 1, 1997 with Richard Garr and Karl Johe for an additional seven (7) years which includes a base salary of $240,000 per year for each officer. On July 28, 2005, the Company granted both Mr. Garr and Mr. Johe stock options for 1,200,000 shares of the Company's common stock each vesting annually over a four year period with an exercise price of $0.50 per share. Termination prior to full term on the contract would cost the Company $240,000 per year unserved, or as much as $1,680,000 per contract, and immediate vesting of all outstanding options.

Note 8.  Subsequent Events

From January 2006 through February 2006, the Company raised $4,540,000 (net of offering expenses of $460,000) through a Limited Offering Memorandum. Each Unit sold consisted of one share of common stock, ½ “A” Warrant to Purchase A share of Common Stock at $1.50 per share, and ½ `B” Warrant to Purchase A Share of Common Stock at $2.00 per share. The Limited Offering Memorandum includes a provision for registration rights of the common stock and shares underlying the Series A and B Warrants. The registration rights require the Company to file a registration statement on Form SB-2 within 30 days from the closing of the minimum offering and have the registration statement declared effective within 180 days. In the even the registration statement is not declared effective within 180 days from the closing of the minimum offering, the number of shares within each unit shall increase by one percent (1%) for each 30 day period (pro rata) beyond the 180 days.

In March 2006, the Company paid off in full a note payable totaling $116,255 as of December 31, 2005, plus interest accrued during 2006, as described in Note 5.

Note 9.  Restatements

For the year ended December 31, 2005, the Company did not account for common stock, warrants, and options to its consultants and note payable conversion properly resulting in additional expenses of $773,000 to operations.

For the year ended December 31, 2004, the Company did not appropriately account for 3,125,000 shares issued to Option Promissory Notes holder which resulted in an additional $5,000,000 of deemed interest expense to operations as discussed in Note 2; incorrectly valued the beneficial conversion feature expenses resulting in an additional $2,272,119 of interest expense.

 

F-16

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NEURALSTEM, INC.

BALANCE SHEET

(Unaudited)

 

  

		June 30,  2006
ASSETS
CURRENT ASSETS
Cash		$	3,202,703
Prepaid expenses			15,021
Total current assets			3,217,724
Property and equipment, net			52,409
Other assets			6,306
Intangible assets, net			13,501
Total assets		$	3,289,940
LIABILITIES AND STOCKHOLDERS’ EQUITY
CURRENT LIABILITIES
Note payable, current portion		$	7,529
Accounts payable and accrued expenses			380,868
Warrants liability			4,953,216
Total current liabilities			5,341,613
Note payable, long-term portion			24,630
Total liabilities			5,366,243
STOCKHOLDERS’ EQUITY
Preferred stock: $0.01 par value; authorized 7,000,000 shares; no shares issued and outstanding		$	-
Common stock: $0.01 par value; authorized 75,000,000 shares; 25,608,272 shares issued and outstanding			256,083
Additional paid-in capital			34,618,529
Common stock receivable for 27,000 shares			(27	)
Common stock payable for 241,000 of unissued shares of common stock			128,000
Accumulated deficit			(37,078,888	)
Total stockholders’ equity			(2,076,303	)
Total liabilities and stockholders’ equity		$	3,289,940

See Accompanying Notes to Financial Statements.

F-17

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NEURALSTEM, INC.

STATEMENTS OF OPERATIONS

(Unaudited)

		Three months ended June 30,						Six months ended June 30,
		2006			2005			2006			2005
Revenues		$	24,724		$	50,000		$	59,211		$	157,813
Operating expenses
Research and development costs			474,593			53,860			824,592			144,949
General, selling and administrative expenses			303,994			32,971			452,558			101,758
Depreciation and amortization			12,981			13,394			25,962			25,962
			791,568			100,225			1,303,112			272,669
Operating loss			(766,844	)		(50,225	)		(1,243,901	)		(114,856	)
Nonoperating income (expense)
Interest			26,673			-			37,163			-
Interest expense			(417	)		-			(8,696	)		-
Loss related to adjustment of warrants
Liability to fair value			-			-			(388,401	)		-
Other expense			(9,938	)		-			(29,815	)		-
Net loss		$	(750,526	)	$	(50,225	)	$	(1,633,650	)	$	(114,856	)
Net loss per share, basic		$	(0.03	)	$	(0.01	)	$	(0.07	)	$	(0.02	)
Average number of shares of common stock outstanding			25,608,272			6,318,201			24,082,587			6,318,201

 

 

See Accompanying Notes to Financial Statements.

F-18

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NEURALSTEM, INC.

STATEMENT OF STOCKHOLDERS’ EQUITY

(Unaudited)   

														Common			Common			Additional
		Preferred Stock						Common Stock						Stock			Stock			Paid-In			Accumulated
		Shares			Amount			Shares			Amount			Receivable			Payable			Capital			Deficit			Total
Balance, December 31, 2005			-		$	-			20,608,272		$	206,083		$	-		$	113,000		$	34,665,982		$	(35,445,238	)		(460,173	)
Issuance of common stock for cash proceeds of $4,550,000 (net of offering expense of $450,000), $1.00 per share			-			-			5,000,000			50,000			-			-			4,500,000			-			4,550,000
Recognition of warrants liability for “A” and “B” warrants for 2,500,000 shares of common stock each, associated with sale of 5,000,000 shares of common stock			-			-			-			-			-			-			(4,550,00	)		-			(4,550,000	)
Vesting of warrants for 6,000 shares of common stock related to consultant			-			-			-			-			-			-			2,520			-			2,520
Receivable for return of 18,000 shares of common stock			-			-			-			-			(27	)		-			27			-			-
Penalty for late filing of registration Statement related to Private Placement Offering			-			-			-			-			-			15,000			-			-			15,000
Net loss			-			-			-			-			-			-			-			(1,633,650	)		(1,633,650	)
Balance, June 30, 2006			-			-			25,608,272		$	256,083		$	(27	)	$	128,000		$	34,618,529		$	(37,078,888	)	$	(2,076,303	)

 

See Accompanying Notes to Financial Statements.

F-19

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NEURALSTEM, INC.

STATEMENTS OF CASH FLOWS

(Unaudited)

 

		Six months ended June 30,
		2006			2005
Cash Flows From Operating Activities
Net loss		$	(1,633,650	)	$	(114,856	)
Adjustments to reconcile net loss to cash used in operating activities:
Depreciation and amortization			26,788			25,962
Stock based expenses			32,335			-
Loss related to adjustment of warrants liability to fair value			388,401			-
Changes in assets and liabilities
Prepaid expenses			(15,021	)		-
Other assets			(6,306	)		-
Accounts payable and accrued expenses			(302,935	)		(153,223	)
Deferred compensation			(192,620	)		-
Net cash used in operating activities			(1,703,008	)		(242,117	)
Cash Flows From Investing Activities
Purchase of property and equipment			(49,233	)		(1,840	)
Net cash used in investing activities			(49,233	)		(1,840	)
Cash Flows From Financing Activities
Issuance of common stock			4,550,000			153,223
Proceeds from notes payable			-			113,500
Payments on notes payable			(121,437	)		(60,000	)
Net cash provided by financing activities			4,428,563			206,723
Net increase (decrease) in cash			2,676,322			(37,234	)
Cash, beginning of period			526,381			39,054
Cash, end of period		$	3,202,703		$	1,820

 

See Accompanying Notes to Financial Statements.

 

F-20

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Note 1.    Summary of Significant Accounting Policies

 

Basis of Presentation:

The accompanying unaudited financial statements have been prepared in accordance with Securities and Exchange Commission requirements for interim financial statements. Therefore, they do not include all of the information and footnotes required by accounting principles generally accepted in the United States for complete financial statements. The financial statements should be read in conjunction with Neuralstem, Inc.’s (the “Company”) annual financial statements for the years ended December 31, 2005 and 2004.

The interim financial statements present the balance sheet, statements of operations, stockholders' equity and cash flows of the Company. The financial statements have been prepared in accordance with accounting principles generally accepted in the United States.

The interim financial information is unaudited. In the opinion of management, all adjustments necessary to present fairly the financial position as of June 30, 2006 and the results of operations and cash flows presented herein have been included in the financial statements. All such adjustments are the recurring and normal nature. Interim results are not necessarily indicative of results of operations for the full year.

Estimates

The preparation of financial statements in accordance with generally accepted accounting principles requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements and the reported amounts of revenues and expenses during the reporting period. Because of the use of estimates inherent in the financial reporting process, actual results could differ significantly from those estimates.

New Accounting Pronouncement Adoption

On January 1, 2006, the Company adopted Statement of Financial Accounting Standards No. 123R (“SFAS 123R”), “Share-Based Payment.” The Company will continue to follow the intrinsic value model under APB Opinion No. 25 for those employee stock option awards granted and unmodified prior to the adoption of SFAS 123R as permitted by paragraph 83 of the new guidance.

 

Note 2.    Stockholders’ Equity

 

From January 2006 through February 2006, the Company raised $4,550,000 (net of offering expenses of $450,000) through a Limited Offering Memorandum. Each Unit sold consisted of one share of common stock, ½ “A” Warrant to Purchase A share of Common Stock at $1.50 per share, and ½ ‘B” Warrant to Purchase A Share of Common Stock at $1.00 per share. These warrants have a life of 10 years.

 

F-21

---

 

Note 3.    Notes payable

In November 2001, the Company entered into an agreement with a bank to borrow $625,000. The note was renegotiated in May 2002 to require principal payments of $25,000 per month beginning August 2002 and to accrue interest at the prime rate plus 1.5% with the balance of principal and accrued interest due on December 9, 2002. The note was renegotiated in December 2002 to require principal payments of $25,000 per month through February 2003, increasing to $40,000 per month starting March 2003, and to accrue interest at the prime rate plus 1.5% with the balance of principal and accrued interest due on June 20, 2003. Substantially all of the Company’s assets provide collateral for the borrowings. As of March 31, 2006, the entire outstanding balance was fully paid.

Note 4.    Warrants liability and common stock payable

Pursuant to the terms of the PPM as discussed in Note 2, the Company entered into a registration rights agreement which requires the Company to file a registration statement in order to register (1) the common shares issued in the PPM; and (2) the common shares issuable upon the exercise of the class “A” and “B” warrants. The registration rights agreement require the Company to file a registration statement as soon as reasonably practicable after the first closing for the offering, but in no event more than 30 days following the closing of the minimum offering amount, which the closing occurred on February 23, 2006. If the Company fail to do so: (i) the shares underlying the “A” and “B” warrants would be increased by one percent (1%) for each 30 day period; and (ii) we would be obligated to issue additional shares equal to one percent (1%) for each 30 day period of the common shares sold in the offering. The registration rights agreement also require the Company on a best effort basis to have the registration statement declared effective within 180 days after the minimum closing and maintain the registration statement continuously effective until the date that the shares covered by the PPM may be sold pursuant to Rule 144 of the Securities Act without any restrictions.

The Company filed its registration statement on April 3, 2006 which was considered 9 days late pursuant to the terms of the PPM. As a result, the Company is obligated to issue an additional 15,000 shares of common stock; “A” warrants for 7,500 shares of common stock and “B” warrants for 7,500 shares of common stock as a penalty for not meeting the 30 day period timeline to file the registration statement. As of June 30, 2006, the Company recorded a common stock payable for 15,000 shares of common stock penalty for a total value of $15,000 and warrants liability for the “A” and “B” warrants penalty of $14,815 which have been recorded as part of “General, selling and administrative” within the statments of operations.

The Company will be reserving approximately 100,000 shares of common stock for potential penalties associated with the PPM, 50,000 for common stock penalty and 25,000 for “A” and “B” warrants, respectively, which the amount to be set aside as a reserve is not necessarily indicative of actual penalties to be incurred.

The “A” and “B” warrants associated with the PPM have been recorded as a liability in accordance with Emerging Issued Task Force No. 00-19. The “A” and “B” warrants fair value totaled $4,938,401 under the Black-Scholes options pricing model. The entire net proceeds of $4,550,000 from the PPM have been allocated as a warrant liability. The difference between the fair values of the “A” and “B” warrants and the net proceeds totaling $388,401 have been recorded as a loss related to adjustment of warrants liability to fair value.

The fair value of the for the “A” and “B” warrant, to include the penalty warrants, were calculated under Black-Scholes option pricing model using the following assumptions: (1) stock price of $1.00; expected life of 5 years; volatility rate of 224%; and discount rate of 4.1%.

F-22

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Note 5.    Common stock receivable

Common stock receivable relates to a penalty provision of an agreement with its placement agent/consultant for not having its registration statement filed within 30 days following the closing of the minimum offering amount of the PPM. The total penalty assessed on the placement agent/consultant totaled 27,000 shares of common stock. As June 30, 2006, the Company accrued $27 as a common stock receivable for 27,000 shares

 

F-23

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PART II

 

INFORMATION NOT REQUIRED IN PROSPECTUS

 

Indemnification Of Directors & Officers

 

 The Corporation Laws of the State of Delaware and the Company's Bylaws provide for indemnification of the Company's Directors for expenses actually and necessarily incurred by them in connection with the defense of any action, suit or proceeding in which they, or any of them, are made parties, or a party, by reason of having been Director(s) or Officer(s) of the corporation, or of such other corporation, except, in relation to matter as to which any such Director or Officer or former Director or Officer or person shall be adjudged in such action, suit or proceeding to be liable for negligence or misconduct in the performance of duty.  Furthermore, the personal liability of the Directors is limited as provided in the Company's Articles of Incorporation.

 

Insofar as indemnification for liabilities arising under the Securities Act of 1933 may be permitted to directors, officers or persons controlling the Company pursuant to the foregoing provisions, the Company has been informed that in the opinion of the Securities and Exchange Commission such indemnification is against public policy as expressed in the Securities Act of 1933 and is therefore unenforceable.

 

Other Expenses of Issuance & Distribution 

 

The following table sets forth an itemization of all estimated expenses, all of which we will pay, in connection with the issuance and distribution of the securities being registered:

 

SEC Registration Fee		$	2,505.18
Financial Printer to EDGARize and Print Registration Statement			3,000.00	*
Tranfer Agent Fees, including Printing and Engraving Stock Certificates			1,000.00	*
Legal Fees and Expense			0.00	(1)
Accounting Fees and Expenses			15,000.00	*
Miscellaneous			2,000.00	*
Total		$	23,505.18	*

 

*Estimated

(1)	Legal Fees and Expenses associated with the filing of this registration are being paid for by Regal One Corporation pursuant to their agreement with the Company.

 

Recent Sales of Unregistered Securities

 

The following information is given with regard to unregistered securities sold during the preceding three years, to August, 2006, including the dates and amounts of securities sold, the persons to whom we sold the securities, the consideration received in connection with such sales and, if the securities were issued or sold other than for cash, the description of the transaction and the type and amount of consideration received.  

 

 

II-2

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·

On October 15, 2005, we granted the J.D. Group, LLC warrants to purchase 1,000,000 common shares at $.50 per share as consideration for services to be provided pursuant to a business advisory services contract. The warrants allow for cashless exercise and contain certain anti-dilution and price adjustment provisions for stock splits, dividends and recapitalizations. The warrants are fully vested on the granted date and expire 9 months after the Company's common shares begin trading on a national exchange or over the counter.

 

·	On November 1, 2005, we issued Equity Communications, LLC a warrant to purchase 330,000 common shares at $.50 per share pursuant to an amended financial public relations service agreement. This warrant vest immediately and expire if not exercised by November 1, 2010.

 

·

On November 7, 2005, we issued to a consultant 120,000 shares of our common stock in fully satisfaction of consulting fees earned and not paid, including interest thereon, in the amount of $60,000. As additional consideration, we also issued the consultant a warrant to purchase 120,000 shares at $.50 per share. The warrant is fully vested and expires three years from the grant date if not exercised.

 

·

On November 7, 2005, we converted a note in the amount of $100,000 to 200,000 shares of our common stock. As additional consideration, we also issued the note holder a warrant to purchase 200,000 shares at $.50 per share. The warrant is fully vested and expires three years from the grant date if not exercised. As a result of an oversight, the shares were not physically issued until the 2nd quarter of 2006.

 

·	On November 14, 2005, we issued Einhorn Associates 78,000 common shares pursuant to a settlement agreement related to fees and services performed.

 

·	On December 23, 2005, we completed the private placement of 1,000,000 common shares to a group of investors at a per share price of $.50. Gross proceeds from the offering totaled $500,000. As a result of an oversight, a portion of the shares were not physically issued until the 2nd quarter of 2006.

 

·	On March 3, 2006, we completed a private placement through T.R. Winston & Company pursuant to which we sold 5,000,000 units to 64 investors at a price of $1.00 per unit, for gross proceeds of $5,000,000. Each unit sold consists of:

·	1 common share;

·	½ class “A” warrant to purchase common shares; and

·	½ class “B” warrant to purchase common shares.

In total, we issued 5,000,000 common shares and 2,500,000 class “A” warrants and 2,500,000 class “B” warrants. The class “A” warrants are exercisable at $1.50 per share and the class “B” warrants are exercisable at $2.00 per share. Both class “A” and “B” warrants are redeemable by the company upon the occurrence of certain events.

·	On March 3, 2006, under the terms of our selling agent agreement with T.R. Winston & Company, we issued a placement agent warrant to purchase 800,000 common shares at $1.10 per share.

II-3

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Exhibits 

 

        The following exhibits are included as part of this Form SB-2. References to "the Company" in this Exhibit List mean Neuralstem, Inc., a Delaware corporation.

Exhibit Number		Description
3.1		Articles of Incorporation of Neuralstem, Inc., as amended
3.2		Corporate Bylaws for Neuralstem, Inc.
4.1		Option & Promissory Note Agreement between Neuralstem, Inc. and Stanley Westreich, dated October 6, 2003
4.2		2005 Stock Option Plan
4.3		Form of Stock Lockup Agreement
4.4		Non-qualified Stock Option Agreement between Neuralstem, Inc. and Richard Garr, dated July 28, 2005
4.5		Non-qualified Stock Option Agreement between Neuralstem, Inc. and Karl Johe, dated July 28, 2005
4.7		Form of $5.00 Option
4.8		September 2005 Stock Subscription Agreement
4.9		Consulting Fee Conversion Agreement and Stock Option Grant between Neuralstem, Inc. and Merrill Solomon, dated November 7, 2005
4.10		Debt Conversion Agreement and Stock Option Grant between Neuralstem, Inc. and Stanley Westreich , dated November 7, 2005.
4.11		Common Stock Purchase Agreement between Neuralstem, Inc. and High Tide, LLC and Steven B. Dunn, dated December 23, 2005
4.12		March 5, 2006 Private Placement Memorandum
4.13		Form of Placement Agent Warrant
4.14		Form of $1.50 Warrant (Series “A”)
4.15		Form of $2.00 Warrant (Series “B”)
4.16		Subscription Agreement for March Private Placement
4.17		Equity Investment and Share Purchase Agreement between Neuralstem, Inc. and Regal One Corporation, effective June 22, 2005 and amended September 15, 2005
5.1		Legal opinion and consent of Dieterich and Associates
10.1		Employment Agreement between CNS Stem Cell Technology, Inc. and I. Richard Garr, dated January 1, 1997 and Amendment, dated November 1, 2005
10.2		Employment Agreement between CNS Stem Cell Technology, Inc. and Karl Johe, dated January 1, 1997 and Amendment, dated November 1, 2005
10.3		Material Transfer and Research Agreement between Neuralstem, Inc. and the Regents of the University of John Hopkins, dated March 2, 2001
10.4		Research Agreement between Neuralstem, Inc. and the Regents of the University of California, San Diego, dated May 15, 2002
10.5		License Agreement between Neuralstem, Inc. and the Maryland Economic Development Corporation, dated Febraury 1, 2004, and Amendment, dated March 14, 2004
10.6		Non-Exclusive Limited License and Material Transfer Agreement between Neuralstem, Inc. and A-T Children's Project, dated December 22, 2004
10.7		Exclusive License Agreement between Neuralstem, Inc. and Biomedical Research Models, Inc., dated February 7, 2005 and Amendment, dated May 20, 2006
10.8		Scientific Advisory Letter & Stock Option Agreement between Neuralstem, Inc. and Thomas Freemen, dated March 21, 2005
10.9		Laboratory Services and Confidentiality Agreement between Neuralstem, Inc. and Biopharmaceutical Services, a division of Charles River Laboratories, dated May 11, 2005
10.10		Business Advisory Services and Warrant Agreement between Neuralstem, Inc. and Richard A. Hull, PhD, dated May 23, 2005
10.11		Limited Exclusive License Agreement between Neuralstem, Inc. and High Med Technologies, Inc., dated July 7, 2005
10.12		Consulting Agreement for Financial Public Relations Services and Non-Qualified Stock Option as Amended between Neuralstem, Inc. and Equity Communications, LLC, dated August 29, 2005 and November 1, 2005
10.13		Research Agreement between Neuralstem, Inc. and the Regents of the University of Southern Florida, dated September 21, 2005

 

---

 

10.14		Business Advisory Services and Warrant Agreement between Neuralstem, Inc. and the J.D. Group, LLC, dated October 15, 2005
10.15		Consulting Fee Conversion Agreement between Neuralstem, Inc. and Einhorn Associates, Inc., dated November 14, 2005
10.16		Lease of Vivarium Room between Neuralstem Inc. and Perry Scientific, dated February 14, 2006
10.17		Research Agreement between Neuralstem, Inc. and the Regents of the University of Central Florida, dated March 1, 2006
14.1		Neuralstem Code of Ethics
23.1		Consent of Dieterich & Associates (included with Exhibit 5.1)
23.2		Consent of Neuralstem's Auditors
99.1		Grant Number 1 R43 MH071958-01A2 from the National Institute of Mental Health to Neuralstem, Inc., issued September 30, 2005
99.2		Grant Number 3 R43 MH071958-01A2S1 from the National Institute of Mental Health to Neuralstem, Inc., issued November 22, 2005
99.3		Award Conditions and Information for National Institute of Health Grants

 

II-5

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SIGNATURES

In accordance with the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form SB−2 and authorized this registration statement to be signed on its behalf by the undersigned, in the City of Rockville, State of Maryland, on August 25, 2006.

	NEURALSTEM, INC.
	By:	/s/ I Richard Garr
		I Richard Garr
		Chief Executive Officer
		(principal executive officer)

	By:	/s/ I Richard Garr
		I. Richard Garr
		Chief Financial Officer
		(principal accounting officer)

In accordance with the requirements of the Securities Act of 1933, this registration statement was signed by the following persons in the capacities and on the dates stated:

KNOW ALL MEN BY THESE PRESENTS, that each person whose signature appears below hereby constitute and appoint I. Richard Garr, as the undersigned's true and lawful attorneys−in−fact and agents, each with full power of substitution and resubstitution for such person and in such person's name, place and stead, in any and all capacities, to sign a registration statement on form SB−2 with respect to Neuralstem, Inc, a Delaware corporation (the "registrant"), and to further sign any and all amendments thereto (including post−effective amendments, exhibits thereto, and other documents in connection therewith to this registration statement and any later registration statement filed by the registrant under Rule 462(b) of the Securities Act of 1933, which relates to this registration statement) and, to file the same with exhibits thereto and other documents in connection therewith with the SEC, granting unto said attorneys−in−fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done, as fully to all intents and purposes as such person might or could do in person, hereby ratifying and confirming all that each of said attorneys−in−fact and agents, or any of them, or their substitute or substitutes may lawfully do or cause to be done by virtue hereof.

By:	/s/  I. Richard Garr             I. Richard Garr	Chief Executive Officer, Chief Financial Officer, President and Director, Principal Accounting Officer	August 25, 2006
By:	/s/ Karl Johe .                   Karl Johe	Chief Scientific Officer, Chairman of the Board and Director	August 25, 2006

II-6

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